A Comparison of Different Sample Processing Protocols for MALDI Imaging Mass Spectrometry Analysis of Formalin-Fixed Multiple Myeloma Cells

A Comparison of Different Sample Processing Protocols for MALDI Imaging Mass Spectrometry Analysis of Formalin-Fixed Multiple Myeloma Cells

Sample processing of formalin-fixed specimens constitutes a major challenge in molecular profiling efforts. Pre-analytical factors such as fixative temperature, dehydration, and embedding media affect downstream analysis, generating data dependent on technical processing rather than disease state. I...

Full description

Bibliographic Details
Main Authors: Rita Casadonte, Jörg Kriegsmann, Mark Kriegsmann, Katharina Kriegsmann, Roberta Torcasio, Maria Eugenia Gallo Cantafio, Giuseppe Viglietto, Nicola Amodio
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
cytospin
FFPE
imaging mass spectrometry
MALDI
sample preparation
Online Access:https://www.mdpi.com/2072-6694/15/3/974

Internet

https://www.mdpi.com/2072-6694/15/3/974

Similar Items