Interleukin-21 promotes thymopoiesis recovery following hematopoietic stem cell transplantation

Interleukin-21 promotes thymopoiesis recovery following hematopoietic stem cell transplantation

Abstract Background Impaired T cell reconstitution remains a major deterrent in the field of bone marrow (BM) transplantation (BMT) due to pre-conditioning-induced damages inflicted to the thymi of recipient hosts. Given the previously reported thymo-stimulatory property of interleukin (IL)-21, we r...

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Bibliographic Details
Main Authors: Aurélie Tormo, Fatemeh Khodayarian, Yun Cui, Edouard Al-Chami, Reem Kanjarawi, Beatriz Noé, Huijie Wang, Moutih Rafei
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Journal of Hematology & Oncology
Subjects:
IL-21
Hematopoietic stem cells
Thymopoiesis
Spleen
Graft-versus-host disease
Regulatory B cells
Online Access:http://link.springer.com/article/10.1186/s13045-017-0490-3

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