“Motile-targeting” drug delivery platforms based on micro/nanorobots for tumor therapy
Traditional drug delivery systems opened the gate for tumor-targeted therapy, but they generally took advantage of enhanced permeability and retention or ligand-receptor mediated interaction, and thus suffered from limited recognition range (<0.5 nm) and low targeting efficiency (0.7%, median...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1002171/full |
| _version_ | 1828404236594970624 |
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| author | Di Zhang Shuyi Liu Jianguo Guan Fangzhi Mou |
| author_facet | Di Zhang Shuyi Liu Jianguo Guan Fangzhi Mou |
| author_sort | Di Zhang |
| collection | DOAJ |
| description | Traditional drug delivery systems opened the gate for tumor-targeted therapy, but they generally took advantage of enhanced permeability and retention or ligand-receptor mediated interaction, and thus suffered from limited recognition range (<0.5 nm) and low targeting efficiency (0.7%, median). Alternatively, micro/nanorobots (MNRs) may act as emerging “motile-targeting” drug delivery platforms to deliver therapeutic payloads, thereby making a giant step toward effective and safe cancer treatment due to their autonomous movement and navigation in biological media. This review focuses on the most recent developments of MNRs in “motile-targeting” drug delivery. After a brief introduction to traditional tumor-targeted drug delivery strategies and various MNRs, the representative applications of MNRs in “motile-targeting” drug delivery are systematically streamlined in terms of the propelling mechanisms. Following a discussion of the current challenges of each type of MNR in biomedical applications, as well as future prospects, several promising designs for MNRs that could benefit in “motile-targeting” drug delivery are proposed. This work is expected to attract and motivate researchers from different communities to advance the creation and practical application of the “motile-targeting” drug delivery platforms. |
| first_indexed | 2024-12-10T10:33:12Z |
| format | Article |
| id | doaj.art-178ce2ddce5446e39234049b7caddc7b |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-10T10:33:12Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-178ce2ddce5446e39234049b7caddc7b2022-12-22T01:52:30ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-09-011010.3389/fbioe.2022.10021711002171“Motile-targeting” drug delivery platforms based on micro/nanorobots for tumor therapyDi ZhangShuyi LiuJianguo GuanFangzhi MouTraditional drug delivery systems opened the gate for tumor-targeted therapy, but they generally took advantage of enhanced permeability and retention or ligand-receptor mediated interaction, and thus suffered from limited recognition range (<0.5 nm) and low targeting efficiency (0.7%, median). Alternatively, micro/nanorobots (MNRs) may act as emerging “motile-targeting” drug delivery platforms to deliver therapeutic payloads, thereby making a giant step toward effective and safe cancer treatment due to their autonomous movement and navigation in biological media. This review focuses on the most recent developments of MNRs in “motile-targeting” drug delivery. After a brief introduction to traditional tumor-targeted drug delivery strategies and various MNRs, the representative applications of MNRs in “motile-targeting” drug delivery are systematically streamlined in terms of the propelling mechanisms. Following a discussion of the current challenges of each type of MNR in biomedical applications, as well as future prospects, several promising designs for MNRs that could benefit in “motile-targeting” drug delivery are proposed. This work is expected to attract and motivate researchers from different communities to advance the creation and practical application of the “motile-targeting” drug delivery platforms.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1002171/fullmicro/nanorobotsmicro/nanomotorsdrug deliverytumor targetingself-propulsion |
| spellingShingle | Di Zhang Shuyi Liu Jianguo Guan Fangzhi Mou “Motile-targeting” drug delivery platforms based on micro/nanorobots for tumor therapy Frontiers in Bioengineering and Biotechnology micro/nanorobots micro/nanomotors drug delivery tumor targeting self-propulsion |
| title | “Motile-targeting” drug delivery platforms based on micro/nanorobots for tumor therapy |
| title_full | “Motile-targeting” drug delivery platforms based on micro/nanorobots for tumor therapy |
| title_fullStr | “Motile-targeting” drug delivery platforms based on micro/nanorobots for tumor therapy |
| title_full_unstemmed | “Motile-targeting” drug delivery platforms based on micro/nanorobots for tumor therapy |
| title_short | “Motile-targeting” drug delivery platforms based on micro/nanorobots for tumor therapy |
| title_sort | motile targeting drug delivery platforms based on micro nanorobots for tumor therapy |
| topic | micro/nanorobots micro/nanomotors drug delivery tumor targeting self-propulsion |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1002171/full |
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