COMPARATIVE ANALYSIS OF SOLUBLE OF CD40 LIGAND LEVELS IN HEART RECIPIENTS TREATED WITH CYCLOSPORINE A AND TACROLIMUS
Soluble form of CD40L is platelet activating factor, which is a marker of inflammation and thrombosis. Elevated levels of sCD40L before the heart transplantation are associated with the risk of early development of cardiova- scular complications. The study included 54 patients who had received heart...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2012-05-01
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| Series: | Vestnik Transplantologii i Iskusstvennyh Organov |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/159 |
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| author | O. P. Shevchenko T. A. Khalilulin O. V. Orlova E. N. Kazakov A. J. Kormer V. V. Сhestukhin B. L. Mironkov |
| author_facet | O. P. Shevchenko T. A. Khalilulin O. V. Orlova E. N. Kazakov A. J. Kormer V. V. Сhestukhin B. L. Mironkov |
| author_sort | O. P. Shevchenko |
| collection | DOAJ |
| description | Soluble form of CD40L is platelet activating factor, which is a marker of inflammation and thrombosis. Elevated levels of sCD40L before the heart transplantation are associated with the risk of early development of cardiova- scular complications. The study included 54 patients who had received heart transplants. All recipients received a triple heart immu- nosuppressive therapy, including methylprednisolone, mycophenolate mofetil and cyclosporine A (20 recipients) or methylprednisolone, mycophenolate mofetil and tacrolimus (34 recipients). Patients were not differed by age, gender, etiology of heart failure before heart transplantation (p > 0,05). In the first group of transplant recipients, the relative risk of cardiovascular events with high sCD40L levels before transplantation was 3 2 (95% CI 1,4; 12,0). In the second group of recipients, respectively, 2.69 (95% CI 1,1; 8,5). SCD40L level after heart transplan- tation was significantly higher for patients receiving cyclosporine (P < 0.05). Increasing concentrations of sCD40L are associated with a higher incidence of cardiovascular complications. |
| first_indexed | 2024-04-10T00:53:44Z |
| format | Article |
| id | doaj.art-178d6f50db8f41058145ee2e91f89ae5 |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2024-04-10T00:53:44Z |
| publishDate | 2012-05-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Vestnik Transplantologii i Iskusstvennyh Organov |
| spelling | doaj.art-178d6f50db8f41058145ee2e91f89ae52023-03-13T10:37:19ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovVestnik Transplantologii i Iskusstvennyh Organov1995-11912012-05-01142202410.15825/1995-1191-2012-2-20-24102COMPARATIVE ANALYSIS OF SOLUBLE OF CD40 LIGAND LEVELS IN HEART RECIPIENTS TREATED WITH CYCLOSPORINE A AND TACROLIMUSO. P. Shevchenko0T. A. Khalilulin1O. V. Orlova2E. N. Kazakov3A. J. Kormer4V. V. Сhestukhin5B. L. Mironkov6Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowSoluble form of CD40L is platelet activating factor, which is a marker of inflammation and thrombosis. Elevated levels of sCD40L before the heart transplantation are associated with the risk of early development of cardiova- scular complications. The study included 54 patients who had received heart transplants. All recipients received a triple heart immu- nosuppressive therapy, including methylprednisolone, mycophenolate mofetil and cyclosporine A (20 recipients) or methylprednisolone, mycophenolate mofetil and tacrolimus (34 recipients). Patients were not differed by age, gender, etiology of heart failure before heart transplantation (p > 0,05). In the first group of transplant recipients, the relative risk of cardiovascular events with high sCD40L levels before transplantation was 3 2 (95% CI 1,4; 12,0). In the second group of recipients, respectively, 2.69 (95% CI 1,1; 8,5). SCD40L level after heart transplan- tation was significantly higher for patients receiving cyclosporine (P < 0.05). Increasing concentrations of sCD40L are associated with a higher incidence of cardiovascular complications.https://journal.transpl.ru/vtio/article/view/159heart transplantation, scd40l, immunosuppression, cardiovascular events |
| spellingShingle | O. P. Shevchenko T. A. Khalilulin O. V. Orlova E. N. Kazakov A. J. Kormer V. V. Сhestukhin B. L. Mironkov COMPARATIVE ANALYSIS OF SOLUBLE OF CD40 LIGAND LEVELS IN HEART RECIPIENTS TREATED WITH CYCLOSPORINE A AND TACROLIMUS Vestnik Transplantologii i Iskusstvennyh Organov heart transplantation, scd40l, immunosuppression, cardiovascular events |
| title | COMPARATIVE ANALYSIS OF SOLUBLE OF CD40 LIGAND LEVELS IN HEART RECIPIENTS TREATED WITH CYCLOSPORINE A AND TACROLIMUS |
| title_full | COMPARATIVE ANALYSIS OF SOLUBLE OF CD40 LIGAND LEVELS IN HEART RECIPIENTS TREATED WITH CYCLOSPORINE A AND TACROLIMUS |
| title_fullStr | COMPARATIVE ANALYSIS OF SOLUBLE OF CD40 LIGAND LEVELS IN HEART RECIPIENTS TREATED WITH CYCLOSPORINE A AND TACROLIMUS |
| title_full_unstemmed | COMPARATIVE ANALYSIS OF SOLUBLE OF CD40 LIGAND LEVELS IN HEART RECIPIENTS TREATED WITH CYCLOSPORINE A AND TACROLIMUS |
| title_short | COMPARATIVE ANALYSIS OF SOLUBLE OF CD40 LIGAND LEVELS IN HEART RECIPIENTS TREATED WITH CYCLOSPORINE A AND TACROLIMUS |
| title_sort | comparative analysis of soluble of cd40 ligand levels in heart recipients treated with cyclosporine a and tacrolimus |
| topic | heart transplantation, scd40l, immunosuppression, cardiovascular events |
| url | https://journal.transpl.ru/vtio/article/view/159 |
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