Characterization and Prognostic Significance of Cutaneous Immune-Related Adverse Events in Indian Patients on Immune Checkpoint Inhibitor Therapy
Introduction: Cutaneous immune-related adverse-events (cIRAEs), commonly seen in cancer patients receiving immune checkpoint inhibitors (ICI) are reported to be associated with better patient survival; however, they have seldom been studied in Indian population. Recent reports suggest racial differe...
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| Format: | Article |
| Language: | English |
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Mattioli1885
2023-07-01
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| Series: | Dermatology Practical & Conceptual |
| Subjects: | |
| Online Access: | http://dpcj.org/index.php/dpc/article/view/2824 |
| _version_ | 1797756350281809920 |
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| author | Prasanna Duraisamy Vinitha Panicker Wesley Jose |
| author_facet | Prasanna Duraisamy Vinitha Panicker Wesley Jose |
| author_sort | Prasanna Duraisamy |
| collection | DOAJ |
| description | Introduction: Cutaneous immune-related adverse-events (cIRAEs), commonly seen in cancer patients receiving immune checkpoint inhibitors (ICI) are reported to be associated with better patient survival; however, they have seldom been studied in Indian population. Recent reports suggest racial differences in IRAEs and also in survival outcomes.
Objective: To study the various cIRAEs in Indian patients on ICI therapy and to analyze the association between cIRAEs and patient survival outcomes.
Methods: We conducted a retrospective cohort study of 86 cancer patients receiving immunotherapies in a tertiary care hospital in India and studied incidence, nature and grades of cutaneous immune-related adverse events and the association of cIRAEs with the patient survival outcomes.
Results: Eighty-six patients were included, of whom 16 patients (18.6%) developed cIRAEs, with pruritus (12.8%) and maculopapular eruption (8.1%) being the most common. Kaplan–Meier plot with log-rank test showed that patients developing any type of cIRAE had longer progression-free survival than those without (p=0.023) and a better objective-response-rate (50% vs 18.5%, p=0.008).
Conclusion: Most common cIRAEs in our study were pruritus and maculopapular rash. The incidence of cIRAEs was lower in our Indian cohort compared to that reported in Caucasian cohorts. Development of cutaneous immune-related adverse event in cancer patients on ICI was associated with a longer progression-free-survival and a better objective-response-rate. Thus, cIRAEs may serve as a surrogate marker for better patient outcomes.
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| first_indexed | 2024-03-12T18:00:06Z |
| format | Article |
| id | doaj.art-178e72d93176492ca1fe2346eb195b1f |
| institution | Directory Open Access Journal |
| issn | 2160-9381 |
| language | English |
| last_indexed | 2024-03-12T18:00:06Z |
| publishDate | 2023-07-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Dermatology Practical & Conceptual |
| spelling | doaj.art-178e72d93176492ca1fe2346eb195b1f2023-08-02T12:23:51ZengMattioli1885Dermatology Practical & Conceptual2160-93812023-07-0113310.5826/dpc.1303a127Characterization and Prognostic Significance of Cutaneous Immune-Related Adverse Events in Indian Patients on Immune Checkpoint Inhibitor TherapyPrasanna Duraisamy0Vinitha Panicker1Wesley Jose2Department of Dermatology, Amrita Institute of Medical Sciences, Kochi, IndiaDepartment of Dermatology, Amrita Institute of Medical Sciences, Kochi, IndiaDepartment of Medical Oncology and Hematology, Amrita Institute of Medical Sciences, Kochi, IndiaIntroduction: Cutaneous immune-related adverse-events (cIRAEs), commonly seen in cancer patients receiving immune checkpoint inhibitors (ICI) are reported to be associated with better patient survival; however, they have seldom been studied in Indian population. Recent reports suggest racial differences in IRAEs and also in survival outcomes. Objective: To study the various cIRAEs in Indian patients on ICI therapy and to analyze the association between cIRAEs and patient survival outcomes. Methods: We conducted a retrospective cohort study of 86 cancer patients receiving immunotherapies in a tertiary care hospital in India and studied incidence, nature and grades of cutaneous immune-related adverse events and the association of cIRAEs with the patient survival outcomes. Results: Eighty-six patients were included, of whom 16 patients (18.6%) developed cIRAEs, with pruritus (12.8%) and maculopapular eruption (8.1%) being the most common. Kaplan–Meier plot with log-rank test showed that patients developing any type of cIRAE had longer progression-free survival than those without (p=0.023) and a better objective-response-rate (50% vs 18.5%, p=0.008). Conclusion: Most common cIRAEs in our study were pruritus and maculopapular rash. The incidence of cIRAEs was lower in our Indian cohort compared to that reported in Caucasian cohorts. Development of cutaneous immune-related adverse event in cancer patients on ICI was associated with a longer progression-free-survival and a better objective-response-rate. Thus, cIRAEs may serve as a surrogate marker for better patient outcomes. http://dpcj.org/index.php/dpc/article/view/2824immune checkpoint inhibitorscutaneous immune related adverse eventsimmunotherapyreactions |
| spellingShingle | Prasanna Duraisamy Vinitha Panicker Wesley Jose Characterization and Prognostic Significance of Cutaneous Immune-Related Adverse Events in Indian Patients on Immune Checkpoint Inhibitor Therapy Dermatology Practical & Conceptual immune checkpoint inhibitors cutaneous immune related adverse events immunotherapy reactions |
| title | Characterization and Prognostic Significance of Cutaneous Immune-Related Adverse Events in Indian Patients on Immune Checkpoint Inhibitor Therapy |
| title_full | Characterization and Prognostic Significance of Cutaneous Immune-Related Adverse Events in Indian Patients on Immune Checkpoint Inhibitor Therapy |
| title_fullStr | Characterization and Prognostic Significance of Cutaneous Immune-Related Adverse Events in Indian Patients on Immune Checkpoint Inhibitor Therapy |
| title_full_unstemmed | Characterization and Prognostic Significance of Cutaneous Immune-Related Adverse Events in Indian Patients on Immune Checkpoint Inhibitor Therapy |
| title_short | Characterization and Prognostic Significance of Cutaneous Immune-Related Adverse Events in Indian Patients on Immune Checkpoint Inhibitor Therapy |
| title_sort | characterization and prognostic significance of cutaneous immune related adverse events in indian patients on immune checkpoint inhibitor therapy |
| topic | immune checkpoint inhibitors cutaneous immune related adverse events immunotherapy reactions |
| url | http://dpcj.org/index.php/dpc/article/view/2824 |
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