Advanced surface engineering of titanium materials for biomedical applications: From static modification to dynamic responsive regulation
Titanium (Ti) and its alloys have been widely used as orthopedic implants, because of their favorable mechanical properties, corrosion resistance and biocompatibility. Despite their significant success in various clinical applications, the probability of failure, degradation and revision is undesira...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-09-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X2300083X |
| _version_ | 1797799936606076928 |
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| author | Pinliang Jiang Yanmei Zhang Ren Hu Bin Shi Lihai Zhang Qiaoling Huang Yun Yang Peifu Tang Changjian Lin |
| author_facet | Pinliang Jiang Yanmei Zhang Ren Hu Bin Shi Lihai Zhang Qiaoling Huang Yun Yang Peifu Tang Changjian Lin |
| author_sort | Pinliang Jiang |
| collection | DOAJ |
| description | Titanium (Ti) and its alloys have been widely used as orthopedic implants, because of their favorable mechanical properties, corrosion resistance and biocompatibility. Despite their significant success in various clinical applications, the probability of failure, degradation and revision is undesirably high, especially for the patients with low bone density, insufficient quantity of bone or osteoporosis, which renders the studies on surface modification of Ti still active to further improve clinical results. It is discerned that surface physicochemical properties directly influence and even control the dynamic interaction that subsequently determines the success or rejection of orthopedic implants. Therefore, it is crucial to endow bulk materials with specific surface properties of high bioactivity that can be performed by surface modification to realize the osseointegration. This article first reviews surface characteristics of Ti materials and various conventional surface modification techniques involving mechanical, physical and chemical treatments based on the formation mechanism of the modified coatings. Such conventional methods are able to improve bioactivity of Ti implants, but the surfaces with static state cannot respond to the dynamic biological cascades from the living cells and tissues. Hence, beyond traditional static design, dynamic responsive avenues are then emerging. The dynamic stimuli sources for surface functionalization can originate from environmental triggers or physiological triggers. In short, this review surveys recent developments in the surface engineering of Ti materials, with a specific emphasis on advances in static to dynamic functionality, which provides perspectives for improving bioactivity and biocompatibility of Ti implants. |
| first_indexed | 2024-03-13T04:26:34Z |
| format | Article |
| id | doaj.art-178efefadb9b487c8c7cd83fc23b555d |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-03-13T04:26:34Z |
| publishDate | 2023-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-178efefadb9b487c8c7cd83fc23b555d2023-06-20T04:20:26ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-09-01271557Advanced surface engineering of titanium materials for biomedical applications: From static modification to dynamic responsive regulationPinliang Jiang0Yanmei Zhang1Ren Hu2Bin Shi3Lihai Zhang4Qiaoling Huang5Yun Yang6Peifu Tang7Changjian Lin8South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, South China University of Technology, Guangzhou, 510640, China; State Key Lab of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, ChinaState Key Lab of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, ChinaState Key Lab of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, ChinaDepartment of Orthopaedics, General Hospital of Chinese PLA, Beijing, 100853, ChinaDepartment of Orthopaedics, General Hospital of Chinese PLA, Beijing, 100853, ChinaResearch Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, College of Physical Science and Technology, Xiamen University, Xiamen, 361005, ChinaResearch Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, College of Physical Science and Technology, Xiamen University, Xiamen, 361005, ChinaDepartment of Orthopaedics, General Hospital of Chinese PLA, Beijing, 100853, China; Corresponding author.State Key Lab of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China; Corresponding author.Titanium (Ti) and its alloys have been widely used as orthopedic implants, because of their favorable mechanical properties, corrosion resistance and biocompatibility. Despite their significant success in various clinical applications, the probability of failure, degradation and revision is undesirably high, especially for the patients with low bone density, insufficient quantity of bone or osteoporosis, which renders the studies on surface modification of Ti still active to further improve clinical results. It is discerned that surface physicochemical properties directly influence and even control the dynamic interaction that subsequently determines the success or rejection of orthopedic implants. Therefore, it is crucial to endow bulk materials with specific surface properties of high bioactivity that can be performed by surface modification to realize the osseointegration. This article first reviews surface characteristics of Ti materials and various conventional surface modification techniques involving mechanical, physical and chemical treatments based on the formation mechanism of the modified coatings. Such conventional methods are able to improve bioactivity of Ti implants, but the surfaces with static state cannot respond to the dynamic biological cascades from the living cells and tissues. Hence, beyond traditional static design, dynamic responsive avenues are then emerging. The dynamic stimuli sources for surface functionalization can originate from environmental triggers or physiological triggers. In short, this review surveys recent developments in the surface engineering of Ti materials, with a specific emphasis on advances in static to dynamic functionality, which provides perspectives for improving bioactivity and biocompatibility of Ti implants.http://www.sciencedirect.com/science/article/pii/S2452199X2300083XTitanium materialsOrthopedic implantsBioactivityStatic modificationDynamic responsive regulation |
| spellingShingle | Pinliang Jiang Yanmei Zhang Ren Hu Bin Shi Lihai Zhang Qiaoling Huang Yun Yang Peifu Tang Changjian Lin Advanced surface engineering of titanium materials for biomedical applications: From static modification to dynamic responsive regulation Bioactive Materials Titanium materials Orthopedic implants Bioactivity Static modification Dynamic responsive regulation |
| title | Advanced surface engineering of titanium materials for biomedical applications: From static modification to dynamic responsive regulation |
| title_full | Advanced surface engineering of titanium materials for biomedical applications: From static modification to dynamic responsive regulation |
| title_fullStr | Advanced surface engineering of titanium materials for biomedical applications: From static modification to dynamic responsive regulation |
| title_full_unstemmed | Advanced surface engineering of titanium materials for biomedical applications: From static modification to dynamic responsive regulation |
| title_short | Advanced surface engineering of titanium materials for biomedical applications: From static modification to dynamic responsive regulation |
| title_sort | advanced surface engineering of titanium materials for biomedical applications from static modification to dynamic responsive regulation |
| topic | Titanium materials Orthopedic implants Bioactivity Static modification Dynamic responsive regulation |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X2300083X |
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