Functional characterization of SGLT1 using SSM-based electrophysiology: Kinetics of sugar binding and translocation

Functional characterization of SGLT1 using SSM-based electrophysiology: Kinetics of sugar binding and translocation

Beside the ongoing efforts to determine structural information, detailed functional studies on transporters are essential to entirely understand the underlying transport mechanisms. We recently found that solid supported membrane-based electrophysiology (SSME) enables the measurement of both sugar b...

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Bibliographic Details
Main Authors: Andre Bazzone, Rocco Zerlotti, Maria Barthmes, Niels Fertig
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Physiology
Subjects:
SGLT1
pre-steady-state kinetics
transport mechanism
solid supported membrane-based electrophysiology
SLC transporters
binding assay
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1058583/full

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