DIETARY PROTEIN INTAKE IS INDEPENDENTLY ASSOCIATED WITH THE URINARY EXCRETION OF PHOSPHATE

Decrease of urinary phosphate (P) excretion and P retention triggers activation of phosphotonins and subsequent development of secondary hyperparathyroidism in progressing of chronic kidney disease (CKD). The main source of P is dietary protein. No large studies are presented to-date to evaluate the...

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Main Authors: Vladimir Dobronravov, Ivan Kaukov, Alexei Smirnov
Format: Article
Language:English
Published: The Korean Society of Nephrology 2012-06-01
Series:Kidney Research and Clinical Practice
Online Access:http://www.sciencedirect.com/science/article/pii/S221191321200407X
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author Vladimir Dobronravov
Ivan Kaukov
Alexei Smirnov
author_facet Vladimir Dobronravov
Ivan Kaukov
Alexei Smirnov
author_sort Vladimir Dobronravov
collection DOAJ
description Decrease of urinary phosphate (P) excretion and P retention triggers activation of phosphotonins and subsequent development of secondary hyperparathyroidism in progressing of chronic kidney disease (CKD). The main source of P is dietary protein. No large studies are presented to-date to evaluate the relationship between dietary protein intake and parameters of P metabolism in CKD patients. This was a goal of the cross-sectional cohort study .11315 CKD patients were entered (males 43%). Median (10th-90th percentile) of age and estimated glomerular filtration rate (GFR) were 46 (24-69) and 64 (24-104). The analyzed data were: age, gender, body mass index (BMI) serum albumin, creatinine, calcium and phosphate; 24-h urine creatinine, phosphate (P),proteinuria (DP). Estimated parameters includes: eGFR, fractional P excretion (FEP), 24-h P excretion (24-h UP), and P clearance (CP). Dietary protein intake (DPI) was based on 24-h urinary urea excretion. No significant differences in serum phosphate were found in groups with various DPI. FEP, 24-h UP and CP were significantly higher in higher DPI range. DPI was positively associated with 24-h UP (β=0,287, p<0.000001) in multivariate model adjusted for age, gender, DP, eGFR, serum P, FEP, BMI, and Ca. Thus, DPI is considered to be the independent factor influencing urinary P excretion and hence contributing to progression of mineral and bone disease in renal dysfunction.
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spelling doaj.art-178f8fb4bec5449fb395f27d9b3920d02022-12-22T02:09:40ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322012-06-01312A28A2910.1016/j.krcp.2012.04.374DIETARY PROTEIN INTAKE IS INDEPENDENTLY ASSOCIATED WITH THE URINARY EXCRETION OF PHOSPHATEVladimir DobronravovIvan KaukovAlexei SmirnovDecrease of urinary phosphate (P) excretion and P retention triggers activation of phosphotonins and subsequent development of secondary hyperparathyroidism in progressing of chronic kidney disease (CKD). The main source of P is dietary protein. No large studies are presented to-date to evaluate the relationship between dietary protein intake and parameters of P metabolism in CKD patients. This was a goal of the cross-sectional cohort study .11315 CKD patients were entered (males 43%). Median (10th-90th percentile) of age and estimated glomerular filtration rate (GFR) were 46 (24-69) and 64 (24-104). The analyzed data were: age, gender, body mass index (BMI) serum albumin, creatinine, calcium and phosphate; 24-h urine creatinine, phosphate (P),proteinuria (DP). Estimated parameters includes: eGFR, fractional P excretion (FEP), 24-h P excretion (24-h UP), and P clearance (CP). Dietary protein intake (DPI) was based on 24-h urinary urea excretion. No significant differences in serum phosphate were found in groups with various DPI. FEP, 24-h UP and CP were significantly higher in higher DPI range. DPI was positively associated with 24-h UP (β=0,287, p<0.000001) in multivariate model adjusted for age, gender, DP, eGFR, serum P, FEP, BMI, and Ca. Thus, DPI is considered to be the independent factor influencing urinary P excretion and hence contributing to progression of mineral and bone disease in renal dysfunction.http://www.sciencedirect.com/science/article/pii/S221191321200407X
spellingShingle Vladimir Dobronravov
Ivan Kaukov
Alexei Smirnov
DIETARY PROTEIN INTAKE IS INDEPENDENTLY ASSOCIATED WITH THE URINARY EXCRETION OF PHOSPHATE
Kidney Research and Clinical Practice
title DIETARY PROTEIN INTAKE IS INDEPENDENTLY ASSOCIATED WITH THE URINARY EXCRETION OF PHOSPHATE
title_full DIETARY PROTEIN INTAKE IS INDEPENDENTLY ASSOCIATED WITH THE URINARY EXCRETION OF PHOSPHATE
title_fullStr DIETARY PROTEIN INTAKE IS INDEPENDENTLY ASSOCIATED WITH THE URINARY EXCRETION OF PHOSPHATE
title_full_unstemmed DIETARY PROTEIN INTAKE IS INDEPENDENTLY ASSOCIATED WITH THE URINARY EXCRETION OF PHOSPHATE
title_short DIETARY PROTEIN INTAKE IS INDEPENDENTLY ASSOCIATED WITH THE URINARY EXCRETION OF PHOSPHATE
title_sort dietary protein intake is independently associated with the urinary excretion of phosphate
url http://www.sciencedirect.com/science/article/pii/S221191321200407X
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AT ivankaukov dietaryproteinintakeisindependentlyassociatedwiththeurinaryexcretionofphosphate
AT alexeismirnov dietaryproteinintakeisindependentlyassociatedwiththeurinaryexcretionofphosphate