DIETARY PROTEIN INTAKE IS INDEPENDENTLY ASSOCIATED WITH THE URINARY EXCRETION OF PHOSPHATE
Decrease of urinary phosphate (P) excretion and P retention triggers activation of phosphotonins and subsequent development of secondary hyperparathyroidism in progressing of chronic kidney disease (CKD). The main source of P is dietary protein. No large studies are presented to-date to evaluate the...
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Format: | Article |
Language: | English |
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The Korean Society of Nephrology
2012-06-01
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Series: | Kidney Research and Clinical Practice |
Online Access: | http://www.sciencedirect.com/science/article/pii/S221191321200407X |
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author | Vladimir Dobronravov Ivan Kaukov Alexei Smirnov |
author_facet | Vladimir Dobronravov Ivan Kaukov Alexei Smirnov |
author_sort | Vladimir Dobronravov |
collection | DOAJ |
description | Decrease of urinary phosphate (P) excretion and P retention triggers activation of phosphotonins and subsequent development of secondary hyperparathyroidism in progressing of chronic kidney disease (CKD). The main source of P is dietary protein. No large studies are presented to-date to evaluate the relationship between dietary protein intake and parameters of P metabolism in CKD patients. This was a goal of the cross-sectional cohort study .11315 CKD patients were entered (males 43%). Median (10th-90th percentile) of age and estimated glomerular filtration rate (GFR) were 46 (24-69) and 64 (24-104). The analyzed data were: age, gender, body mass index (BMI) serum albumin, creatinine, calcium and phosphate; 24-h urine creatinine, phosphate (P),proteinuria (DP). Estimated parameters includes: eGFR, fractional P excretion (FEP), 24-h P excretion (24-h UP), and P clearance (CP). Dietary protein intake (DPI) was based on 24-h urinary urea excretion. No significant differences in serum phosphate were found in groups with various DPI. FEP, 24-h UP and CP were significantly higher in higher DPI range. DPI was positively associated with 24-h UP (β=0,287, p<0.000001) in multivariate model adjusted for age, gender, DP, eGFR, serum P, FEP, BMI, and Ca. Thus, DPI is considered to be the independent factor influencing urinary P excretion and hence contributing to progression of mineral and bone disease in renal dysfunction. |
first_indexed | 2024-04-14T05:35:19Z |
format | Article |
id | doaj.art-178f8fb4bec5449fb395f27d9b3920d0 |
institution | Directory Open Access Journal |
issn | 2211-9132 |
language | English |
last_indexed | 2024-04-14T05:35:19Z |
publishDate | 2012-06-01 |
publisher | The Korean Society of Nephrology |
record_format | Article |
series | Kidney Research and Clinical Practice |
spelling | doaj.art-178f8fb4bec5449fb395f27d9b3920d02022-12-22T02:09:40ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322012-06-01312A28A2910.1016/j.krcp.2012.04.374DIETARY PROTEIN INTAKE IS INDEPENDENTLY ASSOCIATED WITH THE URINARY EXCRETION OF PHOSPHATEVladimir DobronravovIvan KaukovAlexei SmirnovDecrease of urinary phosphate (P) excretion and P retention triggers activation of phosphotonins and subsequent development of secondary hyperparathyroidism in progressing of chronic kidney disease (CKD). The main source of P is dietary protein. No large studies are presented to-date to evaluate the relationship between dietary protein intake and parameters of P metabolism in CKD patients. This was a goal of the cross-sectional cohort study .11315 CKD patients were entered (males 43%). Median (10th-90th percentile) of age and estimated glomerular filtration rate (GFR) were 46 (24-69) and 64 (24-104). The analyzed data were: age, gender, body mass index (BMI) serum albumin, creatinine, calcium and phosphate; 24-h urine creatinine, phosphate (P),proteinuria (DP). Estimated parameters includes: eGFR, fractional P excretion (FEP), 24-h P excretion (24-h UP), and P clearance (CP). Dietary protein intake (DPI) was based on 24-h urinary urea excretion. No significant differences in serum phosphate were found in groups with various DPI. FEP, 24-h UP and CP were significantly higher in higher DPI range. DPI was positively associated with 24-h UP (β=0,287, p<0.000001) in multivariate model adjusted for age, gender, DP, eGFR, serum P, FEP, BMI, and Ca. Thus, DPI is considered to be the independent factor influencing urinary P excretion and hence contributing to progression of mineral and bone disease in renal dysfunction.http://www.sciencedirect.com/science/article/pii/S221191321200407X |
spellingShingle | Vladimir Dobronravov Ivan Kaukov Alexei Smirnov DIETARY PROTEIN INTAKE IS INDEPENDENTLY ASSOCIATED WITH THE URINARY EXCRETION OF PHOSPHATE Kidney Research and Clinical Practice |
title | DIETARY PROTEIN INTAKE IS INDEPENDENTLY ASSOCIATED WITH THE URINARY EXCRETION OF PHOSPHATE |
title_full | DIETARY PROTEIN INTAKE IS INDEPENDENTLY ASSOCIATED WITH THE URINARY EXCRETION OF PHOSPHATE |
title_fullStr | DIETARY PROTEIN INTAKE IS INDEPENDENTLY ASSOCIATED WITH THE URINARY EXCRETION OF PHOSPHATE |
title_full_unstemmed | DIETARY PROTEIN INTAKE IS INDEPENDENTLY ASSOCIATED WITH THE URINARY EXCRETION OF PHOSPHATE |
title_short | DIETARY PROTEIN INTAKE IS INDEPENDENTLY ASSOCIATED WITH THE URINARY EXCRETION OF PHOSPHATE |
title_sort | dietary protein intake is independently associated with the urinary excretion of phosphate |
url | http://www.sciencedirect.com/science/article/pii/S221191321200407X |
work_keys_str_mv | AT vladimirdobronravov dietaryproteinintakeisindependentlyassociatedwiththeurinaryexcretionofphosphate AT ivankaukov dietaryproteinintakeisindependentlyassociatedwiththeurinaryexcretionofphosphate AT alexeismirnov dietaryproteinintakeisindependentlyassociatedwiththeurinaryexcretionofphosphate |