The Role of Outer Membrane Vesicles of Agents of Particularly Dangerous Infections in the Pathogenesis and Immunogenesis of Infectious Process
The literature review is devoted to the modern concepts of the vesiculation phenomenon and its biological role in pathogenic bacteria – causative agents of particularly dangerous human infections. Data on the production, structure, composition, and functions of the outer membrane vesicles (OMV) of b...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2022-01-01
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| Series: | Проблемы особо опасных инфекций |
| Subjects: | |
| Online Access: | https://journal.microbe.ru/jour/article/view/1585 |
| _version_ | 1797220715682856960 |
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| author | N. V. Aronova N. V. Pavlovich M. V. Tsimbalistova S. N. Golovin A. S. Anisimova |
| author_facet | N. V. Aronova N. V. Pavlovich M. V. Tsimbalistova S. N. Golovin A. S. Anisimova |
| author_sort | N. V. Aronova |
| collection | DOAJ |
| description | The literature review is devoted to the modern concepts of the vesiculation phenomenon and its biological role in pathogenic bacteria – causative agents of particularly dangerous human infections. Data on the production, structure, composition, and functions of the outer membrane vesicles (OMV) of bacteria have been summarized. In recent years, the interest of researchers in the formation of spherical structures (so called bubbles or vesicles) from outer membrane of gram-negative bacteria has significantly increased. Such structures are surrounded by the double layer of a phospholipid membrane, the outer layer of which is enriched with lipopolysaccharide molecules. The inner space of vesicles could include various antigens, receptors, adhesins, toxins, enzymes, porins, etc. The formation of vesicles by the outer membranes of bacteria is recognized as a normal physiological manifestation of bacterial activity aimed at adaptation to environmental conditions. The investigation of the biological role of OMV showed their connection with the pathogenesis and immunogenesis of bacterial diseases. The review provides information on the peculiarity of induction, OMV composition and their participation in the processes of patho- and immunogenesis of severe infections caused by groups I–II PBA – the gram-negative causative agents of plague, tularemia, brucellosis, glanders, melioidosis, cholera, and formation of extracellular vesicles in a gram-positive anthrax pathogen. The particular attention is paid to the issue of developing safe and effective next-generation vaccine preparations based on bacterial vesicles. |
| first_indexed | 2024-03-08T13:40:55Z |
| format | Article |
| id | doaj.art-1790841e55dd423e92091ca2d2d8d573 |
| institution | Directory Open Access Journal |
| issn | 0370-1069 2658-719X |
| language | Russian |
| last_indexed | 2024-04-24T12:53:57Z |
| publishDate | 2022-01-01 |
| publisher | Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” |
| record_format | Article |
| series | Проблемы особо опасных инфекций |
| spelling | doaj.art-1790841e55dd423e92091ca2d2d8d5732024-04-05T16:47:16ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2022-01-010461510.21055/0370-1069-2021-4-6-151324The Role of Outer Membrane Vesicles of Agents of Particularly Dangerous Infections in the Pathogenesis and Immunogenesis of Infectious ProcessN. V. Aronova0N. V. Pavlovich1M. V. Tsimbalistova2S. N. Golovin3A. S. Anisimova4Rostov-on-Don Research Anti-Plague InstituteRostov-on-Don Research Anti-Plague InstituteRostov-on-Don Research Anti-Plague InstituteDon State Technical UniversityRostov-on-Don Research Anti-Plague InstituteThe literature review is devoted to the modern concepts of the vesiculation phenomenon and its biological role in pathogenic bacteria – causative agents of particularly dangerous human infections. Data on the production, structure, composition, and functions of the outer membrane vesicles (OMV) of bacteria have been summarized. In recent years, the interest of researchers in the formation of spherical structures (so called bubbles or vesicles) from outer membrane of gram-negative bacteria has significantly increased. Such structures are surrounded by the double layer of a phospholipid membrane, the outer layer of which is enriched with lipopolysaccharide molecules. The inner space of vesicles could include various antigens, receptors, adhesins, toxins, enzymes, porins, etc. The formation of vesicles by the outer membranes of bacteria is recognized as a normal physiological manifestation of bacterial activity aimed at adaptation to environmental conditions. The investigation of the biological role of OMV showed their connection with the pathogenesis and immunogenesis of bacterial diseases. The review provides information on the peculiarity of induction, OMV composition and their participation in the processes of patho- and immunogenesis of severe infections caused by groups I–II PBA – the gram-negative causative agents of plague, tularemia, brucellosis, glanders, melioidosis, cholera, and formation of extracellular vesicles in a gram-positive anthrax pathogen. The particular attention is paid to the issue of developing safe and effective next-generation vaccine preparations based on bacterial vesicles.https://journal.microbe.ru/jour/article/view/1585outer membrane vesiclesparticularly dangerous infectionspathogenesisimmunogenesisvaccines |
| spellingShingle | N. V. Aronova N. V. Pavlovich M. V. Tsimbalistova S. N. Golovin A. S. Anisimova The Role of Outer Membrane Vesicles of Agents of Particularly Dangerous Infections in the Pathogenesis and Immunogenesis of Infectious Process Проблемы особо опасных инфекций outer membrane vesicles particularly dangerous infections pathogenesis immunogenesis vaccines |
| title | The Role of Outer Membrane Vesicles of Agents of Particularly Dangerous Infections in the Pathogenesis and Immunogenesis of Infectious Process |
| title_full | The Role of Outer Membrane Vesicles of Agents of Particularly Dangerous Infections in the Pathogenesis and Immunogenesis of Infectious Process |
| title_fullStr | The Role of Outer Membrane Vesicles of Agents of Particularly Dangerous Infections in the Pathogenesis and Immunogenesis of Infectious Process |
| title_full_unstemmed | The Role of Outer Membrane Vesicles of Agents of Particularly Dangerous Infections in the Pathogenesis and Immunogenesis of Infectious Process |
| title_short | The Role of Outer Membrane Vesicles of Agents of Particularly Dangerous Infections in the Pathogenesis and Immunogenesis of Infectious Process |
| title_sort | role of outer membrane vesicles of agents of particularly dangerous infections in the pathogenesis and immunogenesis of infectious process |
| topic | outer membrane vesicles particularly dangerous infections pathogenesis immunogenesis vaccines |
| url | https://journal.microbe.ru/jour/article/view/1585 |
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