Role of Fatty Acid Kinase in Cellular Lipid Homeostasis and SaeRS-Dependent Virulence Factor Expression in <italic toggle="yes">Staphylococcus aureus</italic>

Role of Fatty Acid Kinase in Cellular Lipid Homeostasis and SaeRS-Dependent Virulence Factor Expression in <italic toggle="yes">Staphylococcus aureus</italic>

ABSTRACT The SaeRS two-component system is a master activator of virulence factor transcription in Staphylococcus aureus, but the cellular factors that control its activity are unknown. Fatty acid (FA) kinase is a two-component enzyme system required for extracellular FA uptake and SaeRS activity. H...

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Bibliographic Details
Main Authors: Megan E. Ericson, Chitra Subramanian, Matthew W. Frank, Charles O. Rock
Format: Article
Language:English
Published: American Society for Microbiology 2017-09-01
Series:mBio
Subjects:
Staphylococcus aureus
fatty acid
hemolysin
phospholipid
two-component regulatory systems
virulence factors
Online Access:https://journals.asm.org/doi/10.1128/mBio.00988-17

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