[18F] Sodium Fluoride Dose Reduction Enabled by Digital Photon Counting PET/CT for Evaluation of Osteoblastic Activity
The aim of the study was to assess the quality and reproducibility of reducing the injected [18F] sodium fluoride ([18F]NaF) dose while maintaining diagnostic imaging quality in bone imaging in a preclinical skeletal model using digital photon counting PET (dPET) detector technology. Beagles (n = 9)...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-01-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.725118/full |
| _version_ | 1818942640734863360 |
|---|---|
| author | Maria I. Menendez Richard R. Moore Mahmoud Abdel-Rasoul Chadwick L. Wright Soledad Fernandez Rebecca D. Jackson Michael V. Knopp |
| author_facet | Maria I. Menendez Richard R. Moore Mahmoud Abdel-Rasoul Chadwick L. Wright Soledad Fernandez Rebecca D. Jackson Michael V. Knopp |
| author_sort | Maria I. Menendez |
| collection | DOAJ |
| description | The aim of the study was to assess the quality and reproducibility of reducing the injected [18F] sodium fluoride ([18F]NaF) dose while maintaining diagnostic imaging quality in bone imaging in a preclinical skeletal model using digital photon counting PET (dPET) detector technology. Beagles (n = 9) were administered three different [18F]NaF doses: 111 MBq (n = 5), 20 MBq (n = 5), and 1.9 MBq (n = 9). Imaging started ≃45 min post-injection for ≃30 min total acquisition time. Images were reconstructed using Time-of-Flight, ultra-high definition (voxel size of 1 × 1 × 1 mm3), with 3 iterations and 3 subsets. Point spread function was modeled and Gaussian filtering was applied. Skeleton qualitative and quantitative molecular image assessment was performed. The overall diagnostic quality of all images scored excellent (61%) and acceptable (39%) by all the reviewers. [18F]NaF SUVmean showed no statistically significant differences among the three doses in any of the region of interest assessed. This study demonstrated that a 60-fold [18F]NaF dose reduction was not significantly different from the highest dose, and it had not significant effect on overall image quality and quantitative accuracy. In the future, ultra-low dose [18F]NaF dPET/CT imaging may significantly decrease PET radiation exposure to preclinical subjects and personnel. |
| first_indexed | 2024-12-20T07:14:39Z |
| format | Article |
| id | doaj.art-1791536044594d539b7b6e27649f3a98 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-20T07:14:39Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-1791536044594d539b7b6e27649f3a982022-12-21T19:48:50ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-01-01810.3389/fmed.2021.725118725118[18F] Sodium Fluoride Dose Reduction Enabled by Digital Photon Counting PET/CT for Evaluation of Osteoblastic ActivityMaria I. Menendez0Richard R. Moore1Mahmoud Abdel-Rasoul2Chadwick L. Wright3Soledad Fernandez4Rebecca D. Jackson5Michael V. Knopp6Department of Radiology, The Wright Center of Innovation in Biomedical Imaging, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDepartment of Radiology, The Wright Center of Innovation in Biomedical Imaging, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesCenter for Biostatistics, College of Medicine, The Ohio State University, Columbus, OH, United StatesDepartment of Radiology, The Wright Center of Innovation in Biomedical Imaging, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesCenter for Biostatistics, College of Medicine, The Ohio State University, Columbus, OH, United StatesDepartment of Internal Medicine, Endocrinology, Diabetes and Metabolism, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDepartment of Radiology, The Wright Center of Innovation in Biomedical Imaging, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesThe aim of the study was to assess the quality and reproducibility of reducing the injected [18F] sodium fluoride ([18F]NaF) dose while maintaining diagnostic imaging quality in bone imaging in a preclinical skeletal model using digital photon counting PET (dPET) detector technology. Beagles (n = 9) were administered three different [18F]NaF doses: 111 MBq (n = 5), 20 MBq (n = 5), and 1.9 MBq (n = 9). Imaging started ≃45 min post-injection for ≃30 min total acquisition time. Images were reconstructed using Time-of-Flight, ultra-high definition (voxel size of 1 × 1 × 1 mm3), with 3 iterations and 3 subsets. Point spread function was modeled and Gaussian filtering was applied. Skeleton qualitative and quantitative molecular image assessment was performed. The overall diagnostic quality of all images scored excellent (61%) and acceptable (39%) by all the reviewers. [18F]NaF SUVmean showed no statistically significant differences among the three doses in any of the region of interest assessed. This study demonstrated that a 60-fold [18F]NaF dose reduction was not significantly different from the highest dose, and it had not significant effect on overall image quality and quantitative accuracy. In the future, ultra-low dose [18F]NaF dPET/CT imaging may significantly decrease PET radiation exposure to preclinical subjects and personnel.https://www.frontiersin.org/articles/10.3389/fmed.2021.725118/full[18F] sodium fluoridePET/CTdigital photon countingbone imagingbone metabolismsodium fluoride dose reduction |
| spellingShingle | Maria I. Menendez Richard R. Moore Mahmoud Abdel-Rasoul Chadwick L. Wright Soledad Fernandez Rebecca D. Jackson Michael V. Knopp [18F] Sodium Fluoride Dose Reduction Enabled by Digital Photon Counting PET/CT for Evaluation of Osteoblastic Activity Frontiers in Medicine [18F] sodium fluoride PET/CT digital photon counting bone imaging bone metabolism sodium fluoride dose reduction |
| title | [18F] Sodium Fluoride Dose Reduction Enabled by Digital Photon Counting PET/CT for Evaluation of Osteoblastic Activity |
| title_full | [18F] Sodium Fluoride Dose Reduction Enabled by Digital Photon Counting PET/CT for Evaluation of Osteoblastic Activity |
| title_fullStr | [18F] Sodium Fluoride Dose Reduction Enabled by Digital Photon Counting PET/CT for Evaluation of Osteoblastic Activity |
| title_full_unstemmed | [18F] Sodium Fluoride Dose Reduction Enabled by Digital Photon Counting PET/CT for Evaluation of Osteoblastic Activity |
| title_short | [18F] Sodium Fluoride Dose Reduction Enabled by Digital Photon Counting PET/CT for Evaluation of Osteoblastic Activity |
| title_sort | 18f sodium fluoride dose reduction enabled by digital photon counting pet ct for evaluation of osteoblastic activity |
| topic | [18F] sodium fluoride PET/CT digital photon counting bone imaging bone metabolism sodium fluoride dose reduction |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.725118/full |
| work_keys_str_mv | AT mariaimenendez 18fsodiumfluoridedosereductionenabledbydigitalphotoncountingpetctforevaluationofosteoblasticactivity AT richardrmoore 18fsodiumfluoridedosereductionenabledbydigitalphotoncountingpetctforevaluationofosteoblasticactivity AT mahmoudabdelrasoul 18fsodiumfluoridedosereductionenabledbydigitalphotoncountingpetctforevaluationofosteoblasticactivity AT chadwicklwright 18fsodiumfluoridedosereductionenabledbydigitalphotoncountingpetctforevaluationofosteoblasticactivity AT soledadfernandez 18fsodiumfluoridedosereductionenabledbydigitalphotoncountingpetctforevaluationofosteoblasticactivity AT rebeccadjackson 18fsodiumfluoridedosereductionenabledbydigitalphotoncountingpetctforevaluationofosteoblasticactivity AT michaelvknopp 18fsodiumfluoridedosereductionenabledbydigitalphotoncountingpetctforevaluationofosteoblasticactivity |