RTA Occupancy of the Origin of Lytic Replication during Murine Gammaherpesvirus 68 Reactivation from B Cell Latency

RTA Occupancy of the Origin of Lytic Replication during Murine Gammaherpesvirus 68 Reactivation from B Cell Latency

RTA, the viral Replication and Transcription Activator, is essential for rhadinovirus lytic gene expression upon de novo infection and reactivation from latency. Lipopolysaccharide (LPS)/toll-like receptor (TLR)4 engagement enhances rhadinovirus reactivation. We developed two new systems to examine...

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Bibliographic Details
Main Authors: Alexis L. Santana, Darby G. Oldenburg, Varvara Kirillov, Laraib Malik, Qiwen Dong, Roman Sinayev, Kenneth B. Marcu, Douglas W. White, Laurie T. Krug
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Pathogens
Subjects:
gammaherpesvirus
latency
reactivation
NF-kappaB
Online Access:http://www.mdpi.com/2076-0817/6/1/9

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