microRNAs in Human Adipose Tissue Physiology and Dysfunction
In recent years, there has been a large amount of evidence on the role of microRNA (miRNA) in regulating adipose tissue physiology. Indeed, miRNAs control critical steps in adipocyte differentiation, proliferation and browning, as well as lipolysis, lipogenesis and adipokine secretion. Overnutrition...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/12/3342 |
| _version_ | 1797505938397069312 |
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| author | Alina Kurylowicz |
| author_facet | Alina Kurylowicz |
| author_sort | Alina Kurylowicz |
| collection | DOAJ |
| description | In recent years, there has been a large amount of evidence on the role of microRNA (miRNA) in regulating adipose tissue physiology. Indeed, miRNAs control critical steps in adipocyte differentiation, proliferation and browning, as well as lipolysis, lipogenesis and adipokine secretion. Overnutrition leads to a significant change in the adipocyte miRNOME, resulting in adipose tissue dysfunction. Moreover, via secreted mediators, dysfunctional adipocytes may impair the function of other organs and tissues. However, given their potential to control cell and whole-body energy expenditure, miRNAs also represent critical therapeutic targets for treating obesity and related metabolic complications. This review attempts to integrate present concepts on the role miRNAs play in adipose tissue physiology and obesity-related dysfunction and data from pre-clinical and clinical studies on the diagnostic or therapeutic potential of miRNA in obesity and its related complications. |
| first_indexed | 2024-03-10T04:25:29Z |
| format | Article |
| id | doaj.art-17922efb862249b2ac9aed3ef9928323 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T04:25:29Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-17922efb862249b2ac9aed3ef99283232023-11-23T07:36:27ZengMDPI AGCells2073-44092021-11-011012334210.3390/cells10123342microRNAs in Human Adipose Tissue Physiology and DysfunctionAlina Kurylowicz0Department of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, PolandIn recent years, there has been a large amount of evidence on the role of microRNA (miRNA) in regulating adipose tissue physiology. Indeed, miRNAs control critical steps in adipocyte differentiation, proliferation and browning, as well as lipolysis, lipogenesis and adipokine secretion. Overnutrition leads to a significant change in the adipocyte miRNOME, resulting in adipose tissue dysfunction. Moreover, via secreted mediators, dysfunctional adipocytes may impair the function of other organs and tissues. However, given their potential to control cell and whole-body energy expenditure, miRNAs also represent critical therapeutic targets for treating obesity and related metabolic complications. This review attempts to integrate present concepts on the role miRNAs play in adipose tissue physiology and obesity-related dysfunction and data from pre-clinical and clinical studies on the diagnostic or therapeutic potential of miRNA in obesity and its related complications.https://www.mdpi.com/2073-4409/10/12/3342microRNA (miRNA)adipose tissueobesity |
| spellingShingle | Alina Kurylowicz microRNAs in Human Adipose Tissue Physiology and Dysfunction Cells microRNA (miRNA) adipose tissue obesity |
| title | microRNAs in Human Adipose Tissue Physiology and Dysfunction |
| title_full | microRNAs in Human Adipose Tissue Physiology and Dysfunction |
| title_fullStr | microRNAs in Human Adipose Tissue Physiology and Dysfunction |
| title_full_unstemmed | microRNAs in Human Adipose Tissue Physiology and Dysfunction |
| title_short | microRNAs in Human Adipose Tissue Physiology and Dysfunction |
| title_sort | micrornas in human adipose tissue physiology and dysfunction |
| topic | microRNA (miRNA) adipose tissue obesity |
| url | https://www.mdpi.com/2073-4409/10/12/3342 |
| work_keys_str_mv | AT alinakurylowicz micrornasinhumanadiposetissuephysiologyanddysfunction |