Simvastatin Ameliorates Matrix Stiffness-Mediated Endothelial Monolayer Disruption.

Simvastatin Ameliorates Matrix Stiffness-Mediated Endothelial Monolayer Disruption.

Arterial stiffening accompanies both aging and atherosclerosis, and age-related stiffening of the arterial intima increases RhoA activity and cell contractility contributing to increased endothelium permeability. Notably, statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibito...

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Bibliographic Details
Main Authors: Marsha C Lampi, Courtney J Faber, John Huynh, Francois Bordeleau, Matthew R Zanotelli, Cynthia A Reinhart-King
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4712048?pdf=render

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