Hemodynamic changes caused by acupuncture in healthy volunteers: a prospective, single-arm exploratory clinical study
Abstract Background Radial pressure pulse wave (RPPW) examination has been a key diagnostic component of traditional Chinese medicine. The objective of this study was to investigate the changes in RPPW along with various hemodynamic variables after acupuncture stimulation and to examine the validity...
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| Format: | Article |
| Language: | English |
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BMC
2017-05-01
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| Series: | BMC Complementary and Alternative Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12906-017-1787-z |
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| author | Tae-Hun Kim Boncho Ku Jang-Han Bae Jae-Young Shin Min-Ho Jun Jung Won Kang Junghwan Kim Jun-Hwan Lee Jaeuk U. Kim |
| author_facet | Tae-Hun Kim Boncho Ku Jang-Han Bae Jae-Young Shin Min-Ho Jun Jung Won Kang Junghwan Kim Jun-Hwan Lee Jaeuk U. Kim |
| author_sort | Tae-Hun Kim |
| collection | DOAJ |
| description | Abstract Background Radial pressure pulse wave (RPPW) examination has been a key diagnostic component of traditional Chinese medicine. The objective of this study was to investigate the changes in RPPW along with various hemodynamic variables after acupuncture stimulation and to examine the validity of pulse diagnosis as a modern diagnostic tool. Methods We conducted acupuncture stimulation at both ST36 acupuncture points in 25 healthy volunteers. We simultaneously assessed the RPPW by pulse tonometry; heart rate variability (HRV) by electrocardiogram; photoplethysmogram (PPG) signals, respiration rate, peripheral blood flow velocity and arterial depth by ultrasonography; and cardiac output by impedance cardiography, before, during and after a session of acupuncture stimulation. Results We observed consistent patterns of increased spectral energy at low frequency (<10 Hz) and pulse power using RPPW examination and in the amplitude and systolic area of the PPG signal during the entire acupuncture session. The low- and high-frequency domains of HRV increased and decreased, respectively, during the acupuncture session. The peripheral blood velocity rose shortly after needle insertion, reached a maximum in the middle of the session and decreased afterwards. The augmentation index (AIX) and pulse transit time (PTT) obtained from RPPW did not change significantly. Conclusion Acupuncture stimulation at ST36 in healthy subjects increased the peripheral pulse amplitudes (pressure pulse wave (PPW) and PPG), blood flow velocity (ultrasonography) and sympathetic nerve activity (HRV). The lack of changes in the AIX and PTT suggests that the increased pulse amplitudes and blood flow velocity may result from increased cardiac output. Trial registration Clinical Research Information Service ( KCT0001663 ). |
| first_indexed | 2024-12-10T21:16:28Z |
| format | Article |
| id | doaj.art-179277b11d2b4075962c167925f90722 |
| institution | Directory Open Access Journal |
| issn | 1472-6882 |
| language | English |
| last_indexed | 2024-12-10T21:16:28Z |
| publishDate | 2017-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary and Alternative Medicine |
| spelling | doaj.art-179277b11d2b4075962c167925f907222022-12-22T01:33:17ZengBMCBMC Complementary and Alternative Medicine1472-68822017-05-0117111210.1186/s12906-017-1787-zHemodynamic changes caused by acupuncture in healthy volunteers: a prospective, single-arm exploratory clinical studyTae-Hun Kim0Boncho Ku1Jang-Han Bae2Jae-Young Shin3Min-Ho Jun4Jung Won Kang5Junghwan Kim6Jun-Hwan Lee7Jaeuk U. Kim8Korean Medicine Clinical Trial Center, Kyung Hee University Korean Medicine HospitalKM Fundamental Research Division, Korea Institute of Oriental MedicineKM Fundamental Research Division, Korea Institute of Oriental MedicineClinical Research Division, Korea Institute of Oriental MedicineKM Fundamental Research Division, Korea Institute of Oriental MedicineDepartment of Acupuncture & Moxibustion, College of Korean Medicine, Kyung Hee UniversityDepartment of Acupuncture & Moxibustion, College of Korean Medicine, Kyung Hee UniversityClinical Research Division, Korea Institute of Oriental MedicineKM Fundamental Research Division, Korea Institute of Oriental MedicineAbstract Background Radial pressure pulse wave (RPPW) examination has been a key diagnostic component of traditional Chinese medicine. The objective of this study was to investigate the changes in RPPW along with various hemodynamic variables after acupuncture stimulation and to examine the validity of pulse diagnosis as a modern diagnostic tool. Methods We conducted acupuncture stimulation at both ST36 acupuncture points in 25 healthy volunteers. We simultaneously assessed the RPPW by pulse tonometry; heart rate variability (HRV) by electrocardiogram; photoplethysmogram (PPG) signals, respiration rate, peripheral blood flow velocity and arterial depth by ultrasonography; and cardiac output by impedance cardiography, before, during and after a session of acupuncture stimulation. Results We observed consistent patterns of increased spectral energy at low frequency (<10 Hz) and pulse power using RPPW examination and in the amplitude and systolic area of the PPG signal during the entire acupuncture session. The low- and high-frequency domains of HRV increased and decreased, respectively, during the acupuncture session. The peripheral blood velocity rose shortly after needle insertion, reached a maximum in the middle of the session and decreased afterwards. The augmentation index (AIX) and pulse transit time (PTT) obtained from RPPW did not change significantly. Conclusion Acupuncture stimulation at ST36 in healthy subjects increased the peripheral pulse amplitudes (pressure pulse wave (PPW) and PPG), blood flow velocity (ultrasonography) and sympathetic nerve activity (HRV). The lack of changes in the AIX and PTT suggests that the increased pulse amplitudes and blood flow velocity may result from increased cardiac output. Trial registration Clinical Research Information Service ( KCT0001663 ).http://link.springer.com/article/10.1186/s12906-017-1787-zAcupunctureRadial artery pressure pulse waveRadial artery ultrasonographyKIOM-PASHemodynamic variables |
| spellingShingle | Tae-Hun Kim Boncho Ku Jang-Han Bae Jae-Young Shin Min-Ho Jun Jung Won Kang Junghwan Kim Jun-Hwan Lee Jaeuk U. Kim Hemodynamic changes caused by acupuncture in healthy volunteers: a prospective, single-arm exploratory clinical study BMC Complementary and Alternative Medicine Acupuncture Radial artery pressure pulse wave Radial artery ultrasonography KIOM-PAS Hemodynamic variables |
| title | Hemodynamic changes caused by acupuncture in healthy volunteers: a prospective, single-arm exploratory clinical study |
| title_full | Hemodynamic changes caused by acupuncture in healthy volunteers: a prospective, single-arm exploratory clinical study |
| title_fullStr | Hemodynamic changes caused by acupuncture in healthy volunteers: a prospective, single-arm exploratory clinical study |
| title_full_unstemmed | Hemodynamic changes caused by acupuncture in healthy volunteers: a prospective, single-arm exploratory clinical study |
| title_short | Hemodynamic changes caused by acupuncture in healthy volunteers: a prospective, single-arm exploratory clinical study |
| title_sort | hemodynamic changes caused by acupuncture in healthy volunteers a prospective single arm exploratory clinical study |
| topic | Acupuncture Radial artery pressure pulse wave Radial artery ultrasonography KIOM-PAS Hemodynamic variables |
| url | http://link.springer.com/article/10.1186/s12906-017-1787-z |
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