The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders
Obesity is often associated with cognitive and mood disorders. Recent evidence suggests that obesity may cause hypothalamic inflammation. Our aim was to investigate the hypothesis that there is a causal link between obesity-induced hypothalamic inflammation and cognitive and mood disorders. Inflamma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/2/498 |
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| author | Sofia Dionysopoulou Evangelia Charmandari Alexandra Bargiota Nikolaos F Vlahos George Mastorakos Georgios Valsamakis |
| author_facet | Sofia Dionysopoulou Evangelia Charmandari Alexandra Bargiota Nikolaos F Vlahos George Mastorakos Georgios Valsamakis |
| author_sort | Sofia Dionysopoulou |
| collection | DOAJ |
| description | Obesity is often associated with cognitive and mood disorders. Recent evidence suggests that obesity may cause hypothalamic inflammation. Our aim was to investigate the hypothesis that there is a causal link between obesity-induced hypothalamic inflammation and cognitive and mood disorders. Inflammation may influence hypothalamic inter-connections with regions important for cognition and mood, while it may cause dysregulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis and influence monoaminergic systems. Exercise, healthy diet, and glucagon-like peptide receptor agonists, which can reduce hypothalamic inflammation in obese models, could improve the deleterious effects on cognition and mood. |
| first_indexed | 2024-03-09T05:56:59Z |
| format | Article |
| id | doaj.art-17928294858b45f79193d2b83ccdca40 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T05:56:59Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-17928294858b45f79193d2b83ccdca402023-12-03T12:12:19ZengMDPI AGNutrients2072-66432021-02-0113249810.3390/nu13020498The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood DisordersSofia Dionysopoulou0Evangelia Charmandari1Alexandra Bargiota2Nikolaos F Vlahos3George Mastorakos4Georgios Valsamakis5Division of Endocrinology, Metabolism and Diabetes, Hippocratio General Hospital, 11527 Athens, GreeceDivision of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, ‘Aghia Sophia’ Children’s Hospital, 11527 Athens, GreeceDepartment of Endocrinology and Metabolic Diseases, University Hospital of Larisa, Medical School of Larisa, University of Thessaly, 41334 Larisa, Greece2nd Department of Obstetrics and Gynecology, Areteion University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, GreeceEndocrine Unit, Areteion University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, GreeceDepartment of Endocrinology and Metabolic Diseases, University Hospital of Larisa, Medical School of Larisa, University of Thessaly, 41334 Larisa, GreeceObesity is often associated with cognitive and mood disorders. Recent evidence suggests that obesity may cause hypothalamic inflammation. Our aim was to investigate the hypothesis that there is a causal link between obesity-induced hypothalamic inflammation and cognitive and mood disorders. Inflammation may influence hypothalamic inter-connections with regions important for cognition and mood, while it may cause dysregulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis and influence monoaminergic systems. Exercise, healthy diet, and glucagon-like peptide receptor agonists, which can reduce hypothalamic inflammation in obese models, could improve the deleterious effects on cognition and mood.https://www.mdpi.com/2072-6643/13/2/498dietobesityhypothalamic inflammationcognitive disordersmood disordersdepression |
| spellingShingle | Sofia Dionysopoulou Evangelia Charmandari Alexandra Bargiota Nikolaos F Vlahos George Mastorakos Georgios Valsamakis The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders Nutrients diet obesity hypothalamic inflammation cognitive disorders mood disorders depression |
| title | The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders |
| title_full | The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders |
| title_fullStr | The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders |
| title_full_unstemmed | The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders |
| title_short | The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders |
| title_sort | role of hypothalamic inflammation in diet induced obesity and its association with cognitive and mood disorders |
| topic | diet obesity hypothalamic inflammation cognitive disorders mood disorders depression |
| url | https://www.mdpi.com/2072-6643/13/2/498 |
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