Prevalence of meningococcal carriage in children and adolescents aged 10–19 years in Chile in 2013
Summary: In 2011, Chile experienced an increase in the number of cases of IMD caused by Neisseria meningitidis group W. This epidemiological scenario prompted authorities to implement prevention strategies. As part of these strategies, the Institute of Public Heath of Chile conducted a cross-section...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-07-01
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| Series: | Journal of Infection and Public Health |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034116000022 |
| _version_ | 1819206863592357888 |
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| author | Janepsy Díaz Marcela Cárcamo Mabel Seoane Paola Pidal Gabriel Cavada Rodrigo Puentes Solana Terrazas Pamela Araya Ana B. Ibarz-Pavon Macarena Manríquez Juan C. Hormazábal Salvador Ayala María T. Valenzuela |
| author_facet | Janepsy Díaz Marcela Cárcamo Mabel Seoane Paola Pidal Gabriel Cavada Rodrigo Puentes Solana Terrazas Pamela Araya Ana B. Ibarz-Pavon Macarena Manríquez Juan C. Hormazábal Salvador Ayala María T. Valenzuela |
| author_sort | Janepsy Díaz |
| collection | DOAJ |
| description | Summary: In 2011, Chile experienced an increase in the number of cases of IMD caused by Neisseria meningitidis group W. This epidemiological scenario prompted authorities to implement prevention strategies. As part of these strategies, the Institute of Public Heath of Chile conducted a cross-sectional study to determine the prevalence of pharyngeal carriage of N. meningitidis in a representative sample of healthy children and adolescents aged 10–19 years.The identification of presumptive N. meningitidis strains was performed by testing carbohydrate utilization in the National Reference Laboratory at the ISP. Association of meningococcal carriage with risk factors was analyzed by calculating the Odds Ratio. Selected variables were included in a logistic model for risk analyses.The prevalence of carriage of N. meningitidis was 6.5% (CI: 5.7–7.3%). Older age (carriers: 14.2 ± 0.29 vs. non-carriers: 13.8 ± 0.08 years old; p = 0.009), cohabitation with children (carriers: 0.9 ± 0.13 vs. non-carriers: 0.7 ± 0.03; p = 0.028), number of smoking cohabitants (carriers: 0.55 ± 0.13 vs. non-carriers: 0.44 ± 0.03) and frequent attendance to crowded social venues (carriers: 49% vs. non-carriers: 37%; p = 0.008) were determined to favor carriage. Statistical modeling showed that meningococcal carriage was associated with older age (OR: 1.077, p-value: 0.002) and cohabitation with children (OR: 1.182, p-value: 0.02). Keywords: Neisseria meningitidis, Prevalence, Multivariate logistic regression, IMD, Meningococcal carriage, Risk factors |
| first_indexed | 2024-12-23T05:14:22Z |
| format | Article |
| id | doaj.art-1793562879bc4758b24b4752dfce4132 |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-12-23T05:14:22Z |
| publishDate | 2016-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-1793562879bc4758b24b4752dfce41322022-12-21T17:58:53ZengElsevierJournal of Infection and Public Health1876-03412016-07-0194506515Prevalence of meningococcal carriage in children and adolescents aged 10–19 years in Chile in 2013Janepsy Díaz0Marcela Cárcamo1Mabel Seoane2Paola Pidal3Gabriel Cavada4Rodrigo Puentes5Solana Terrazas6Pamela Araya7Ana B. Ibarz-Pavon8Macarena Manríquez9Juan C. Hormazábal10Salvador Ayala11María T. Valenzuela12Departamento de Asuntos Científicos, Instituto de Salud Pública de Chile, Santiago, Chile; Corresponding author. Tel.: +56 2 25755612.Departamento de Asuntos Científicos, Instituto de Salud Pública de Chile, Santiago, ChileDepartamento de Laboratorio Biomédico Nacional de Referencia, Instituto de Salud Pública de Chile, Santiago, ChileDepartamento de Laboratorio Biomédico Nacional de Referencia, Instituto de Salud Pública de Chile, Santiago, ChileDepartamento de Asuntos Científicos, Instituto de Salud Pública de Chile, Santiago, ChileDepartamento de Asuntos Científicos, Instituto de Salud Pública de Chile, Santiago, ChileDepartamento de Asuntos Científicos, Instituto de Salud Pública de Chile, Santiago, ChileDepartamento de Laboratorio Biomédico Nacional de Referencia, Instituto de Salud Pública de Chile, Santiago, ChilePan-American Health Organization/World Health Organization, Washington, DC, USADepartamento de Asuntos Científicos, Instituto de Salud Pública de Chile, Santiago, ChileDepartamento de Laboratorio Biomédico Nacional de Referencia, Instituto de Salud Pública de Chile, Santiago, ChileDepartamento de Asuntos Científicos, Instituto de Salud Pública de Chile, Santiago, ChileInstituto de Salud Pública de Chile, Santiago, ChileSummary: In 2011, Chile experienced an increase in the number of cases of IMD caused by Neisseria meningitidis group W. This epidemiological scenario prompted authorities to implement prevention strategies. As part of these strategies, the Institute of Public Heath of Chile conducted a cross-sectional study to determine the prevalence of pharyngeal carriage of N. meningitidis in a representative sample of healthy children and adolescents aged 10–19 years.The identification of presumptive N. meningitidis strains was performed by testing carbohydrate utilization in the National Reference Laboratory at the ISP. Association of meningococcal carriage with risk factors was analyzed by calculating the Odds Ratio. Selected variables were included in a logistic model for risk analyses.The prevalence of carriage of N. meningitidis was 6.5% (CI: 5.7–7.3%). Older age (carriers: 14.2 ± 0.29 vs. non-carriers: 13.8 ± 0.08 years old; p = 0.009), cohabitation with children (carriers: 0.9 ± 0.13 vs. non-carriers: 0.7 ± 0.03; p = 0.028), number of smoking cohabitants (carriers: 0.55 ± 0.13 vs. non-carriers: 0.44 ± 0.03) and frequent attendance to crowded social venues (carriers: 49% vs. non-carriers: 37%; p = 0.008) were determined to favor carriage. Statistical modeling showed that meningococcal carriage was associated with older age (OR: 1.077, p-value: 0.002) and cohabitation with children (OR: 1.182, p-value: 0.02). Keywords: Neisseria meningitidis, Prevalence, Multivariate logistic regression, IMD, Meningococcal carriage, Risk factorshttp://www.sciencedirect.com/science/article/pii/S1876034116000022 |
| spellingShingle | Janepsy Díaz Marcela Cárcamo Mabel Seoane Paola Pidal Gabriel Cavada Rodrigo Puentes Solana Terrazas Pamela Araya Ana B. Ibarz-Pavon Macarena Manríquez Juan C. Hormazábal Salvador Ayala María T. Valenzuela Prevalence of meningococcal carriage in children and adolescents aged 10–19 years in Chile in 2013 Journal of Infection and Public Health |
| title | Prevalence of meningococcal carriage in children and adolescents aged 10–19 years in Chile in 2013 |
| title_full | Prevalence of meningococcal carriage in children and adolescents aged 10–19 years in Chile in 2013 |
| title_fullStr | Prevalence of meningococcal carriage in children and adolescents aged 10–19 years in Chile in 2013 |
| title_full_unstemmed | Prevalence of meningococcal carriage in children and adolescents aged 10–19 years in Chile in 2013 |
| title_short | Prevalence of meningococcal carriage in children and adolescents aged 10–19 years in Chile in 2013 |
| title_sort | prevalence of meningococcal carriage in children and adolescents aged 10 19 years in chile in 2013 |
| url | http://www.sciencedirect.com/science/article/pii/S1876034116000022 |
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