Evaluation of MR perfusion abnormalities in organophosphorus poisoning and its correlation with SPECT
Aim: Acute organophosphate (OP) pesticide poisoning causes substantial morbidity and mortality worldwide. Many imaging modalities, such as computerized tomography (CT), magnetic resonance imaging (MRI), and single photon emission computed tomography (SPECT) of the brain, have been used for quantitat...
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| Format: | Article |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2017-01-01
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| Series: | Indian Journal of Radiology and Imaging |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/0971-3026.202961 |
| _version_ | 1818613694288887808 |
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| author | K Uday Bhanu Niranjan Khandelwal Sameer Vyas Paramjeet Singh Anuj Prabhakar B R Mittal Ashish Bhalla |
| author_facet | K Uday Bhanu Niranjan Khandelwal Sameer Vyas Paramjeet Singh Anuj Prabhakar B R Mittal Ashish Bhalla |
| author_sort | K Uday Bhanu |
| collection | DOAJ |
| description | Aim: Acute organophosphate (OP) pesticide poisoning causes substantial morbidity and mortality worldwide. Many imaging modalities, such as computerized tomography (CT), magnetic resonance imaging (MRI), and single photon emission computed tomography (SPECT) of the brain, have been used for quantitative assessment of the acute brain insult caused by acute OP poisoning. Perfusion defects on SPECT in acutely poisoned patients with OPs have been described, however, MR perfusion abnormalities have not been described in the literature. MR perfusion Imaging has the advantage of having higher spatial resolution, no radiation, and better availability. Materials and Methods:In this prospective study, 20 patients who ingested OP compounds were included. All the patients underwent brain SPECT on a dual head SPECT gamma camera and MRI brain on a 1.5T MR system. Neurocognitive tests were performed for all patients.Results: SPECT showed perfusion defects in 7 patients and total number of perfusion defects were 29. On MR perfusion, based on the cut-off values of normalized cerebral blood volume (nCBV) ratios and normalized cerebral blood flow (nCBF) ratios, the total number of patients showing perfusion defects were 6 and 8; and the total number of perfusion defects were 29 and 45, respectively. There was significant difference of the nCBV ratios and nCBF ratios between the control group (n = 20) and positive patients group (n = 6 and n = 8, respectively) (P > 0.05). All the defects seen on SPECT were well appreciated on nCBF maps (MRI perfusion) suggestive of 100% correlation. Conclusion: MR perfusion imaging can be used as an effective modality for evaluation in acute OP poisoning. |
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| id | doaj.art-1796e10035404f8da129c3e266c70d43 |
| institution | Directory Open Access Journal |
| issn | 0971-3026 1998-3808 |
| language | English |
| last_indexed | 2024-12-16T16:06:11Z |
| publishDate | 2017-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Radiology and Imaging |
| spelling | doaj.art-1796e10035404f8da129c3e266c70d432022-12-21T22:25:21ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Radiology and Imaging0971-30261998-38082017-01-012701364210.4103/0971-3026.202961Evaluation of MR perfusion abnormalities in organophosphorus poisoning and its correlation with SPECTK Uday Bhanu0Niranjan Khandelwal1Sameer Vyas2Paramjeet Singh3Anuj Prabhakar4B R Mittal5Ashish Bhalla6Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaDepartment of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaDepartment of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaDepartment of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaDepartment of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaDepartment of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaDepartment of Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaAim: Acute organophosphate (OP) pesticide poisoning causes substantial morbidity and mortality worldwide. Many imaging modalities, such as computerized tomography (CT), magnetic resonance imaging (MRI), and single photon emission computed tomography (SPECT) of the brain, have been used for quantitative assessment of the acute brain insult caused by acute OP poisoning. Perfusion defects on SPECT in acutely poisoned patients with OPs have been described, however, MR perfusion abnormalities have not been described in the literature. MR perfusion Imaging has the advantage of having higher spatial resolution, no radiation, and better availability. Materials and Methods:In this prospective study, 20 patients who ingested OP compounds were included. All the patients underwent brain SPECT on a dual head SPECT gamma camera and MRI brain on a 1.5T MR system. Neurocognitive tests were performed for all patients.Results: SPECT showed perfusion defects in 7 patients and total number of perfusion defects were 29. On MR perfusion, based on the cut-off values of normalized cerebral blood volume (nCBV) ratios and normalized cerebral blood flow (nCBF) ratios, the total number of patients showing perfusion defects were 6 and 8; and the total number of perfusion defects were 29 and 45, respectively. There was significant difference of the nCBV ratios and nCBF ratios between the control group (n = 20) and positive patients group (n = 6 and n = 8, respectively) (P > 0.05). All the defects seen on SPECT were well appreciated on nCBF maps (MRI perfusion) suggestive of 100% correlation. Conclusion: MR perfusion imaging can be used as an effective modality for evaluation in acute OP poisoning.http://www.thieme-connect.de/DOI/DOI?10.4103/0971-3026.202961magnetic resonance imagingorganophosphorus poisoningsingle photon emission computed tomography |
| spellingShingle | K Uday Bhanu Niranjan Khandelwal Sameer Vyas Paramjeet Singh Anuj Prabhakar B R Mittal Ashish Bhalla Evaluation of MR perfusion abnormalities in organophosphorus poisoning and its correlation with SPECT Indian Journal of Radiology and Imaging magnetic resonance imaging organophosphorus poisoning single photon emission computed tomography |
| title | Evaluation of MR perfusion abnormalities in organophosphorus poisoning and its correlation with SPECT |
| title_full | Evaluation of MR perfusion abnormalities in organophosphorus poisoning and its correlation with SPECT |
| title_fullStr | Evaluation of MR perfusion abnormalities in organophosphorus poisoning and its correlation with SPECT |
| title_full_unstemmed | Evaluation of MR perfusion abnormalities in organophosphorus poisoning and its correlation with SPECT |
| title_short | Evaluation of MR perfusion abnormalities in organophosphorus poisoning and its correlation with SPECT |
| title_sort | evaluation of mr perfusion abnormalities in organophosphorus poisoning and its correlation with spect |
| topic | magnetic resonance imaging organophosphorus poisoning single photon emission computed tomography |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/0971-3026.202961 |
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