The evaluation of hepatoma-derived growth factor in determining of prognosis and estimating of invasive probability of tumoral cells, recurrent, and metastasis of lymphatic glands in breast carcinoma
Introduction: Recently, hepatoma-derived growth factor (HDGF) has been considered as a significantly important factor in determining the prognosis and estimating the probability of tumor cell invasions, recurrence, and lymph node metastasis in different cancers, including breast malignancies. Materi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Journal of Family Medicine and Primary Care |
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| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2017;volume=6;issue=4;spage=770;epage=774;aulast=Kazeminezhad |
| _version_ | 1811193737036955648 |
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| author | Behrang Kazeminezhad Behdad Baradaran Mohammad Reza Hafezi Ahmadi |
| author_facet | Behrang Kazeminezhad Behdad Baradaran Mohammad Reza Hafezi Ahmadi |
| author_sort | Behrang Kazeminezhad |
| collection | DOAJ |
| description | Introduction: Recently, hepatoma-derived growth factor (HDGF) has been considered as a significantly important factor in determining the prognosis and estimating the probability of tumor cell invasions, recurrence, and lymph node metastasis in different cancers, including breast malignancies. Materials and Methods: Immunohistochemistry (IHC) study for HDGF was performed on paraffin-embedded blocks of patients with breast carcinoma in Modarres hospital, Tehran, Iran, since 1387–1390 (74 cases); three separate pathologists read the slides after complete IHC staining. Thereafter, necessary information was recorded from patient files, and eventually, findings were analyzed by SPSS program. Results: Expression of nuclear HDGF has significant statistical correlation with tumor grade according to Nottingham grading scheme; this correlation is also seen with nuclear pleomorphism of tumor cells and mitotic count. No correlation between age and tumor size with expression of HDGF is found. Lymph node metastasis is in inverse ratio to nuclear HDGF staining. Conclusion: Nuclear expression of HDGF in tumor cells is increased concordantly to tumor grade, which implies us to the role of this marker in determining the prognosis and choosing the most suitable treatment plan. |
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| id | doaj.art-1799a50787734b86901284f1760b4e9d |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-04-12T00:14:34Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-1799a50787734b86901284f1760b4e9d2022-12-22T03:55:52ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632017-01-016477077410.4103/jfmpc.jfmpc_177_17The evaluation of hepatoma-derived growth factor in determining of prognosis and estimating of invasive probability of tumoral cells, recurrent, and metastasis of lymphatic glands in breast carcinomaBehrang KazeminezhadBehdad BaradaranMohammad Reza Hafezi AhmadiIntroduction: Recently, hepatoma-derived growth factor (HDGF) has been considered as a significantly important factor in determining the prognosis and estimating the probability of tumor cell invasions, recurrence, and lymph node metastasis in different cancers, including breast malignancies. Materials and Methods: Immunohistochemistry (IHC) study for HDGF was performed on paraffin-embedded blocks of patients with breast carcinoma in Modarres hospital, Tehran, Iran, since 1387–1390 (74 cases); three separate pathologists read the slides after complete IHC staining. Thereafter, necessary information was recorded from patient files, and eventually, findings were analyzed by SPSS program. Results: Expression of nuclear HDGF has significant statistical correlation with tumor grade according to Nottingham grading scheme; this correlation is also seen with nuclear pleomorphism of tumor cells and mitotic count. No correlation between age and tumor size with expression of HDGF is found. Lymph node metastasis is in inverse ratio to nuclear HDGF staining. Conclusion: Nuclear expression of HDGF in tumor cells is increased concordantly to tumor grade, which implies us to the role of this marker in determining the prognosis and choosing the most suitable treatment plan.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2017;volume=6;issue=4;spage=770;epage=774;aulast=KazeminezhadBreast carcinomahepatoma-derived growth factorimmunohistochemistry |
| spellingShingle | Behrang Kazeminezhad Behdad Baradaran Mohammad Reza Hafezi Ahmadi The evaluation of hepatoma-derived growth factor in determining of prognosis and estimating of invasive probability of tumoral cells, recurrent, and metastasis of lymphatic glands in breast carcinoma Journal of Family Medicine and Primary Care Breast carcinoma hepatoma-derived growth factor immunohistochemistry |
| title | The evaluation of hepatoma-derived growth factor in determining of prognosis and estimating of invasive probability of tumoral cells, recurrent, and metastasis of lymphatic glands in breast carcinoma |
| title_full | The evaluation of hepatoma-derived growth factor in determining of prognosis and estimating of invasive probability of tumoral cells, recurrent, and metastasis of lymphatic glands in breast carcinoma |
| title_fullStr | The evaluation of hepatoma-derived growth factor in determining of prognosis and estimating of invasive probability of tumoral cells, recurrent, and metastasis of lymphatic glands in breast carcinoma |
| title_full_unstemmed | The evaluation of hepatoma-derived growth factor in determining of prognosis and estimating of invasive probability of tumoral cells, recurrent, and metastasis of lymphatic glands in breast carcinoma |
| title_short | The evaluation of hepatoma-derived growth factor in determining of prognosis and estimating of invasive probability of tumoral cells, recurrent, and metastasis of lymphatic glands in breast carcinoma |
| title_sort | evaluation of hepatoma derived growth factor in determining of prognosis and estimating of invasive probability of tumoral cells recurrent and metastasis of lymphatic glands in breast carcinoma |
| topic | Breast carcinoma hepatoma-derived growth factor immunohistochemistry |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2017;volume=6;issue=4;spage=770;epage=774;aulast=Kazeminezhad |
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