Effects of growth and mutation on pattern formation in tissues.
In many developing tissues, neighboring cells enter different developmental pathways, resulting in a fine-grained pattern of different cell states. The most common mechanism that generates such patterns is lateral inhibition, for example through Delta-Notch coupling. In this work, we simulate growth...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23144963/?tool=EBI |
| _version_ | 1818574428140732416 |
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| author | Benedicte Mengel Pers Sandeep Krishna Sagar Chakraborty Simone Pigolotti Vedran Sekara Szabolcs Semsey Mogens H Jensen |
| author_facet | Benedicte Mengel Pers Sandeep Krishna Sagar Chakraborty Simone Pigolotti Vedran Sekara Szabolcs Semsey Mogens H Jensen |
| author_sort | Benedicte Mengel Pers |
| collection | DOAJ |
| description | In many developing tissues, neighboring cells enter different developmental pathways, resulting in a fine-grained pattern of different cell states. The most common mechanism that generates such patterns is lateral inhibition, for example through Delta-Notch coupling. In this work, we simulate growth of tissues consisting of a hexagonal arrangement of cells laterally inhibiting their neighbors. We find that tissue growth by cell division and cell migration tends to produce ordered patterns, whereas lateral growth leads to disordered, patchy patterns. Ordered patterns are very robust to mutations (gene silencing or activation) in single cells. In contrast, mutation in a cell of a disordered tissue can produce a larger and more widespread perturbation of the pattern. In tissues where ordered and disordered patches coexist, the perturbations spread mostly at boundaries between patches. If cell division occurs on time scales faster than the degradation time, disordered patches will appear. Our work suggests that careful experimental characterization of the disorder in tissues could pinpoint where and how the tissue is susceptible to large-scale damage even from single cell mutations. |
| first_indexed | 2024-12-15T00:26:31Z |
| format | Article |
| id | doaj.art-179a850b9b9e4fdea9bedd0f9f5f771a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-15T00:26:31Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-179a850b9b9e4fdea9bedd0f9f5f771a2022-12-21T22:42:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01711e4877210.1371/journal.pone.0048772Effects of growth and mutation on pattern formation in tissues.Benedicte Mengel PersSandeep KrishnaSagar ChakrabortySimone PigolottiVedran SekaraSzabolcs SemseyMogens H JensenIn many developing tissues, neighboring cells enter different developmental pathways, resulting in a fine-grained pattern of different cell states. The most common mechanism that generates such patterns is lateral inhibition, for example through Delta-Notch coupling. In this work, we simulate growth of tissues consisting of a hexagonal arrangement of cells laterally inhibiting their neighbors. We find that tissue growth by cell division and cell migration tends to produce ordered patterns, whereas lateral growth leads to disordered, patchy patterns. Ordered patterns are very robust to mutations (gene silencing or activation) in single cells. In contrast, mutation in a cell of a disordered tissue can produce a larger and more widespread perturbation of the pattern. In tissues where ordered and disordered patches coexist, the perturbations spread mostly at boundaries between patches. If cell division occurs on time scales faster than the degradation time, disordered patches will appear. Our work suggests that careful experimental characterization of the disorder in tissues could pinpoint where and how the tissue is susceptible to large-scale damage even from single cell mutations.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23144963/?tool=EBI |
| spellingShingle | Benedicte Mengel Pers Sandeep Krishna Sagar Chakraborty Simone Pigolotti Vedran Sekara Szabolcs Semsey Mogens H Jensen Effects of growth and mutation on pattern formation in tissues. PLoS ONE |
| title | Effects of growth and mutation on pattern formation in tissues. |
| title_full | Effects of growth and mutation on pattern formation in tissues. |
| title_fullStr | Effects of growth and mutation on pattern formation in tissues. |
| title_full_unstemmed | Effects of growth and mutation on pattern formation in tissues. |
| title_short | Effects of growth and mutation on pattern formation in tissues. |
| title_sort | effects of growth and mutation on pattern formation in tissues |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23144963/?tool=EBI |
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