Moxifloxacin Induced Seizures -A Case Report.
A 73-year-old female patient developed a generalized tonic-clonic seizure on the 6th day after treatment with moxifloxacin 400 mg daily intravenously for appendicitis. This patient had atrial fibrillation and history of a surgery for intracerebral hemorrhage, with impaired renal function and liver f...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2014-09-01
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| Series: | Iranian Journal of Public Health |
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| Online Access: | https://ijph.tums.ac.ir/index.php/ijph/article/view/3918 |
| _version_ | 1818663275662934016 |
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| author | Jiana Shi Huimin Xu |
| author_facet | Jiana Shi Huimin Xu |
| author_sort | Jiana Shi |
| collection | DOAJ |
| description | A 73-year-old female patient developed a generalized tonic-clonic seizure on the 6th day after treatment with moxifloxacin 400 mg daily intravenously for appendicitis. This patient had atrial fibrillation and history of a surgery for intracerebral hemorrhage, with impaired renal function and liver function, but without history of seizures. Moxifloxacin was discontinued and switched to cefuroxime. The patient remained seizure-free at discharge four days later. The naranjo adverse drug reaction probability scale score was 4, indicating a possible adverse reaction to moxifloxacin. The potential risk factors related to moxifloxacin-induced seizures are discussed. It highlights that preexisting central nervous system disease, elderly female with lower bodyweight and severe renal impairment may be the risk factors involved in moxifloxacin-induced seizures. |
| first_indexed | 2024-12-17T05:14:16Z |
| format | Article |
| id | doaj.art-179ae14a0cea46dc8b89f88c8a125cbe |
| institution | Directory Open Access Journal |
| issn | 2251-6085 2251-6093 |
| language | English |
| last_indexed | 2024-12-17T05:14:16Z |
| publishDate | 2014-09-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Public Health |
| spelling | doaj.art-179ae14a0cea46dc8b89f88c8a125cbe2022-12-21T22:02:09ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932014-09-014393773Moxifloxacin Induced Seizures -A Case Report.Jiana Shi0Huimin Xu11. Dept. of Pharmacy, the Second Affiliated Hospital, School of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009 , China ; 2. Dept. of Pharmacy, Tongde Hospital of Zhejiang Province, Hangzhou 310012 , China.1. Dept. of Pharmacy, the Second Affiliated Hospital, School of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009 , China.A 73-year-old female patient developed a generalized tonic-clonic seizure on the 6th day after treatment with moxifloxacin 400 mg daily intravenously for appendicitis. This patient had atrial fibrillation and history of a surgery for intracerebral hemorrhage, with impaired renal function and liver function, but without history of seizures. Moxifloxacin was discontinued and switched to cefuroxime. The patient remained seizure-free at discharge four days later. The naranjo adverse drug reaction probability scale score was 4, indicating a possible adverse reaction to moxifloxacin. The potential risk factors related to moxifloxacin-induced seizures are discussed. It highlights that preexisting central nervous system disease, elderly female with lower bodyweight and severe renal impairment may be the risk factors involved in moxifloxacin-induced seizures.https://ijph.tums.ac.ir/index.php/ijph/article/view/3918AntibioticsFluoroquinolonesMoxifloxacinSeizuresSide effects |
| spellingShingle | Jiana Shi Huimin Xu Moxifloxacin Induced Seizures -A Case Report. Iranian Journal of Public Health Antibiotics Fluoroquinolones Moxifloxacin Seizures Side effects |
| title | Moxifloxacin Induced Seizures -A Case Report. |
| title_full | Moxifloxacin Induced Seizures -A Case Report. |
| title_fullStr | Moxifloxacin Induced Seizures -A Case Report. |
| title_full_unstemmed | Moxifloxacin Induced Seizures -A Case Report. |
| title_short | Moxifloxacin Induced Seizures -A Case Report. |
| title_sort | moxifloxacin induced seizures a case report |
| topic | Antibiotics Fluoroquinolones Moxifloxacin Seizures Side effects |
| url | https://ijph.tums.ac.ir/index.php/ijph/article/view/3918 |
| work_keys_str_mv | AT jianashi moxifloxacininducedseizuresacasereport AT huiminxu moxifloxacininducedseizuresacasereport |