Treatment outcome and its predictors among patients of acute heart failure at a tertiary care hospital in Ethiopia: a prospective observational study
Abstract Background Acute heart failure is a rapid onset of new or worsening of signs and symptoms of heart failure that requires hospitalization or a visit to the emergency department. The aim of this study was to evaluate treatment outcome and determine factors that predict a poor treatment outcom...
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-019-01318-x |
| _version_ | 1818331253780250624 |
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| author | Mulubirhan Tirfe Teshome Nedi Desalew Mekonnen Alemseged Beyene Berha |
| author_facet | Mulubirhan Tirfe Teshome Nedi Desalew Mekonnen Alemseged Beyene Berha |
| author_sort | Mulubirhan Tirfe |
| collection | DOAJ |
| description | Abstract Background Acute heart failure is a rapid onset of new or worsening of signs and symptoms of heart failure that requires hospitalization or a visit to the emergency department. The aim of this study was to evaluate treatment outcome and determine factors that predict a poor treatment outcome in acute heart failure patients at a Tertiary Care Hospital in Ethiopia. Methods A prospective observational study design was used. Data were collected using a structured questionnaire as a tool. Outcome variables were assessed at the time of discharge from the hospital. Bivariate and multivariate logistic regression analyses were used to determine factors that predict in-hospital mortality. A p-value ≤0.05 was considered as statistically significant. Results Out of the 169 patients, the median age of patients with acute heart failure was 34 years (IQR = 23 to 50) and median hospital stay was 4.0 days (IQR = 3.0 to 6.0). The leading precipitating factor and underlying disease at the time of admission were pneumonia (47.5%) and chronic rheumatic heart disease (48.5%), respectively. The in-hospital mortality was found to be 17.2%. Smoking (adjusted odds ratio (AOR) = 8.7, p = 0.006), diabetes mellitus (AOR = 10.2, p = 0.005), pulmonary hypertension (AOR = 4.3, p = 0.016), and the presence of adverse drug events (AOR = 4.2, p = 0.003) were predictors of in-hospital mortality. Conclusion High in-hospital mortality was observed among acute heart failure patients admitted to a Tertiary Care Hospital in Ethiopia. Smoking, diabetes mellitus, pulmonary hypertension and the presence of adverse drug events were predictors of in-hospital mortality. |
| first_indexed | 2024-12-13T13:16:55Z |
| format | Article |
| id | doaj.art-179ba319193b4a18be047854804d10e6 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-13T13:16:55Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-179ba319193b4a18be047854804d10e62022-12-21T23:44:30ZengBMCBMC Cardiovascular Disorders1471-22612020-01-0120111010.1186/s12872-019-01318-xTreatment outcome and its predictors among patients of acute heart failure at a tertiary care hospital in Ethiopia: a prospective observational studyMulubirhan Tirfe0Teshome Nedi1Desalew Mekonnen2Alemseged Beyene Berha3Department of Pharmacy, College of Health Sciences and Comprehensive Specialized Hospital, Aksum UniversityDepartment of Pharmacology and Clinical Pharmacy, School of Pharmacy , College of Health Sciences, Addis Ababa UniversityDepartment of Internal Medicine, School of Medicine, College of Health Sciences, Addis Ababa UniversityDepartment of Pharmacology and Clinical Pharmacy, School of Pharmacy , College of Health Sciences, Addis Ababa UniversityAbstract Background Acute heart failure is a rapid onset of new or worsening of signs and symptoms of heart failure that requires hospitalization or a visit to the emergency department. The aim of this study was to evaluate treatment outcome and determine factors that predict a poor treatment outcome in acute heart failure patients at a Tertiary Care Hospital in Ethiopia. Methods A prospective observational study design was used. Data were collected using a structured questionnaire as a tool. Outcome variables were assessed at the time of discharge from the hospital. Bivariate and multivariate logistic regression analyses were used to determine factors that predict in-hospital mortality. A p-value ≤0.05 was considered as statistically significant. Results Out of the 169 patients, the median age of patients with acute heart failure was 34 years (IQR = 23 to 50) and median hospital stay was 4.0 days (IQR = 3.0 to 6.0). The leading precipitating factor and underlying disease at the time of admission were pneumonia (47.5%) and chronic rheumatic heart disease (48.5%), respectively. The in-hospital mortality was found to be 17.2%. Smoking (adjusted odds ratio (AOR) = 8.7, p = 0.006), diabetes mellitus (AOR = 10.2, p = 0.005), pulmonary hypertension (AOR = 4.3, p = 0.016), and the presence of adverse drug events (AOR = 4.2, p = 0.003) were predictors of in-hospital mortality. Conclusion High in-hospital mortality was observed among acute heart failure patients admitted to a Tertiary Care Hospital in Ethiopia. Smoking, diabetes mellitus, pulmonary hypertension and the presence of adverse drug events were predictors of in-hospital mortality.https://doi.org/10.1186/s12872-019-01318-xAcute heart failureIn-hospital mortalityPredictor of mortalityEthiopia |
| spellingShingle | Mulubirhan Tirfe Teshome Nedi Desalew Mekonnen Alemseged Beyene Berha Treatment outcome and its predictors among patients of acute heart failure at a tertiary care hospital in Ethiopia: a prospective observational study BMC Cardiovascular Disorders Acute heart failure In-hospital mortality Predictor of mortality Ethiopia |
| title | Treatment outcome and its predictors among patients of acute heart failure at a tertiary care hospital in Ethiopia: a prospective observational study |
| title_full | Treatment outcome and its predictors among patients of acute heart failure at a tertiary care hospital in Ethiopia: a prospective observational study |
| title_fullStr | Treatment outcome and its predictors among patients of acute heart failure at a tertiary care hospital in Ethiopia: a prospective observational study |
| title_full_unstemmed | Treatment outcome and its predictors among patients of acute heart failure at a tertiary care hospital in Ethiopia: a prospective observational study |
| title_short | Treatment outcome and its predictors among patients of acute heart failure at a tertiary care hospital in Ethiopia: a prospective observational study |
| title_sort | treatment outcome and its predictors among patients of acute heart failure at a tertiary care hospital in ethiopia a prospective observational study |
| topic | Acute heart failure In-hospital mortality Predictor of mortality Ethiopia |
| url | https://doi.org/10.1186/s12872-019-01318-x |
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