Identification, Characterization and Functional Analysis of Fibroblast Growth Factors in Black Rockfish (<i>Sebastes schlegelii</i>)
Fibroblast growth factors (FGFs) are short polypeptides that play essential roles in various cellular biological processes, including cell migration, proliferation, and differentiation, as well as tissue regeneration, immune response, and organogenesis. However, studies focusing on the characterizat...
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/4/3626 |
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| author | Chaofan Jin Kai Yan Mengya Wang Weihao Song Xiangfu Kong Zhengrui Zhang |
| author_facet | Chaofan Jin Kai Yan Mengya Wang Weihao Song Xiangfu Kong Zhengrui Zhang |
| author_sort | Chaofan Jin |
| collection | DOAJ |
| description | Fibroblast growth factors (FGFs) are short polypeptides that play essential roles in various cellular biological processes, including cell migration, proliferation, and differentiation, as well as tissue regeneration, immune response, and organogenesis. However, studies focusing on the characterization and function of FGF genes in teleost fishes are still limited. In this study, we identified and characterized expression patterns of 24 FGF genes in various tissues of embryonic and adult specimens of the black rockfish (<i>Sebates schlegelii</i>). Nine FGF genes were found to play essential roles in myoblast differentiation, as well as muscle development and recovery in juvelines of <i>S. schlegelii</i>. Moreover, sex-biased expression pattern of multiple FGF genes was recorded in the species’ gonads during its development. Among them, expression of the <i>FGF1</i> gene was recorded in interstitial and sertoli cells of testes, promoting germ-cell proliferation and differentiation. In sum, the obtained results enabled systematic and functional characterization of FGF genes in <i>S. schlegelii</i>, laying a foundation for further studies on FGF genes in other large teleost fishes. |
| first_indexed | 2024-03-11T08:42:38Z |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:42:38Z |
| publishDate | 2023-02-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-179e0ba603da4bf09cd9aeac133e3ad72023-11-16T21:02:42ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244362610.3390/ijms24043626Identification, Characterization and Functional Analysis of Fibroblast Growth Factors in Black Rockfish (<i>Sebastes schlegelii</i>)Chaofan Jin0Kai Yan1Mengya Wang2Weihao Song3Xiangfu Kong4Zhengrui Zhang5MOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, ChinaMOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, ChinaMOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, ChinaMOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, ChinaMOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, ChinaMOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, ChinaFibroblast growth factors (FGFs) are short polypeptides that play essential roles in various cellular biological processes, including cell migration, proliferation, and differentiation, as well as tissue regeneration, immune response, and organogenesis. However, studies focusing on the characterization and function of FGF genes in teleost fishes are still limited. In this study, we identified and characterized expression patterns of 24 FGF genes in various tissues of embryonic and adult specimens of the black rockfish (<i>Sebates schlegelii</i>). Nine FGF genes were found to play essential roles in myoblast differentiation, as well as muscle development and recovery in juvelines of <i>S. schlegelii</i>. Moreover, sex-biased expression pattern of multiple FGF genes was recorded in the species’ gonads during its development. Among them, expression of the <i>FGF1</i> gene was recorded in interstitial and sertoli cells of testes, promoting germ-cell proliferation and differentiation. In sum, the obtained results enabled systematic and functional characterization of FGF genes in <i>S. schlegelii</i>, laying a foundation for further studies on FGF genes in other large teleost fishes.https://www.mdpi.com/1422-0067/24/4/3626fibroblast growth factorsmuscle developmentgonad development<i>FGF1</i><i>Sebastes schlegelii</i> |
| spellingShingle | Chaofan Jin Kai Yan Mengya Wang Weihao Song Xiangfu Kong Zhengrui Zhang Identification, Characterization and Functional Analysis of Fibroblast Growth Factors in Black Rockfish (<i>Sebastes schlegelii</i>) International Journal of Molecular Sciences fibroblast growth factors muscle development gonad development <i>FGF1</i> <i>Sebastes schlegelii</i> |
| title | Identification, Characterization and Functional Analysis of Fibroblast Growth Factors in Black Rockfish (<i>Sebastes schlegelii</i>) |
| title_full | Identification, Characterization and Functional Analysis of Fibroblast Growth Factors in Black Rockfish (<i>Sebastes schlegelii</i>) |
| title_fullStr | Identification, Characterization and Functional Analysis of Fibroblast Growth Factors in Black Rockfish (<i>Sebastes schlegelii</i>) |
| title_full_unstemmed | Identification, Characterization and Functional Analysis of Fibroblast Growth Factors in Black Rockfish (<i>Sebastes schlegelii</i>) |
| title_short | Identification, Characterization and Functional Analysis of Fibroblast Growth Factors in Black Rockfish (<i>Sebastes schlegelii</i>) |
| title_sort | identification characterization and functional analysis of fibroblast growth factors in black rockfish i sebastes schlegelii i |
| topic | fibroblast growth factors muscle development gonad development <i>FGF1</i> <i>Sebastes schlegelii</i> |
| url | https://www.mdpi.com/1422-0067/24/4/3626 |
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