Preoperative high-sensitive troponin T and N-terminal pro B-type natriuretic peptide in prediction of short-term mortality after non-cardiac surgery (High-sensitive troponin T and N-terminal pro B-type natriuretuc peptide in prediciton of mortality after non-cardiac surgery)
Background and Aims: The aim of this study was to evaluate potential of prognostic cardiac biomarkers by predicting fatal events during perioperative period and the significance of their increased values in all patients and with coronary artery disease (CAD). Methods: The study included 87 patients...
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| Format: | Article |
| Language: | English |
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Serbian Society of Anesthesiologists and Intensivists
2018-01-01
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| Series: | Serbian Journal of Anesthesia and Intensive Therapy |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2217-7744/2018/2217-77441808163S.pdf |
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| author | Savić Nenad Golubović Ilija Stojanović Milena Vuković Anita Marković Danica Janković Radmilo |
| author_facet | Savić Nenad Golubović Ilija Stojanović Milena Vuković Anita Marković Danica Janković Radmilo |
| author_sort | Savić Nenad |
| collection | DOAJ |
| description | Background and Aims: The aim of this study was to evaluate potential of prognostic cardiac biomarkers by predicting fatal events during perioperative period and the significance of their increased values in all patients and with coronary artery disease (CAD). Methods: The study included 87 patients who underwent major abdominal and vascular surgery. Blood samples were taken from all patients prior to surgery and levels of high-sensitive troponin T (hsTnT) and N-Terminal Pro B-type natriuretic peptide (NT-proBNP) were measured. It was analyzed how their increased values (above the predefined cut-offs of > 14 ng/L and > 300 pg/mL respectively) was associated with perioperative mortality in both all subjects and in patients with CAD. Results: Median value of hsTnT in survival group was 11.29 ng/L (interquartile range - IQR, 6.03-18.57) vs. 26.62 ng/L (IQR, 21.48-76.31) in non-survival group, p = 0.045 and for NT-proBNP in survival group was 259.05 pg/mL (IQR, 93.03-447.45) vs. 759.2 pg/mL (IQR, 433-6095) in non-survival group, p = 0.017. The odds ratio of mortality was presented in the form of direct association for both measured biomarkers - not only in patients with CAD but also in all included patients. Conclusions: Preoperatively increased hsTnT and NT-proBNP indicate high mortality risk during perioperative period. Because of the association between increased cardiac biomarker and mortality events in patients with CAD, special attention is necessary in preparation for major surgery. |
| first_indexed | 2024-04-13T03:23:39Z |
| format | Article |
| id | doaj.art-179e6a163dad44a2982565fa674ea0cc |
| institution | Directory Open Access Journal |
| issn | 2466-488X 2466-488X |
| language | English |
| last_indexed | 2024-04-13T03:23:39Z |
| publishDate | 2018-01-01 |
| publisher | Serbian Society of Anesthesiologists and Intensivists |
| record_format | Article |
| series | Serbian Journal of Anesthesia and Intensive Therapy |
| spelling | doaj.art-179e6a163dad44a2982565fa674ea0cc2022-12-22T03:04:42ZengSerbian Society of Anesthesiologists and IntensivistsSerbian Journal of Anesthesia and Intensive Therapy2466-488X2466-488X2018-01-01407-81631702217-77441808163SPreoperative high-sensitive troponin T and N-terminal pro B-type natriuretic peptide in prediction of short-term mortality after non-cardiac surgery (High-sensitive troponin T and N-terminal pro B-type natriuretuc peptide in prediciton of mortality after non-cardiac surgery)Savić Nenad0Golubović Ilija1Stojanović Milena2Vuković Anita3Marković Danica4Janković Radmilo5Clinical Center Niš, Clinic for anesthesia and intensive therapy, NišClinical Center Niš, Department of General surgery, NišClinical Center Niš, Clinic for anesthesia and intensive therapy, NišClinical Center Niš, Clinic for anesthesia and intensive therapy, NišClinical Center Niš, Clinic for anesthesia and intensive therapy, NišClinical Center Niš, Clinic for anesthesia and intensive therapy, NišBackground and Aims: The aim of this study was to evaluate potential of prognostic cardiac biomarkers by predicting fatal events during perioperative period and the significance of their increased values in all patients and with coronary artery disease (CAD). Methods: The study included 87 patients who underwent major abdominal and vascular surgery. Blood samples were taken from all patients prior to surgery and levels of high-sensitive troponin T (hsTnT) and N-Terminal Pro B-type natriuretic peptide (NT-proBNP) were measured. It was analyzed how their increased values (above the predefined cut-offs of > 14 ng/L and > 300 pg/mL respectively) was associated with perioperative mortality in both all subjects and in patients with CAD. Results: Median value of hsTnT in survival group was 11.29 ng/L (interquartile range - IQR, 6.03-18.57) vs. 26.62 ng/L (IQR, 21.48-76.31) in non-survival group, p = 0.045 and for NT-proBNP in survival group was 259.05 pg/mL (IQR, 93.03-447.45) vs. 759.2 pg/mL (IQR, 433-6095) in non-survival group, p = 0.017. The odds ratio of mortality was presented in the form of direct association for both measured biomarkers - not only in patients with CAD but also in all included patients. Conclusions: Preoperatively increased hsTnT and NT-proBNP indicate high mortality risk during perioperative period. Because of the association between increased cardiac biomarker and mortality events in patients with CAD, special attention is necessary in preparation for major surgery.https://scindeks-clanci.ceon.rs/data/pdf/2217-7744/2018/2217-77441808163S.pdfcardiac biomarkersshort-term mortalityperioperative risknon-cardiac surgerycoronary artery disease |
| spellingShingle | Savić Nenad Golubović Ilija Stojanović Milena Vuković Anita Marković Danica Janković Radmilo Preoperative high-sensitive troponin T and N-terminal pro B-type natriuretic peptide in prediction of short-term mortality after non-cardiac surgery (High-sensitive troponin T and N-terminal pro B-type natriuretuc peptide in prediciton of mortality after non-cardiac surgery) Serbian Journal of Anesthesia and Intensive Therapy cardiac biomarkers short-term mortality perioperative risk non-cardiac surgery coronary artery disease |
| title | Preoperative high-sensitive troponin T and N-terminal pro B-type natriuretic peptide in prediction of short-term mortality after non-cardiac surgery (High-sensitive troponin T and N-terminal pro B-type natriuretuc peptide in prediciton of mortality after non-cardiac surgery) |
| title_full | Preoperative high-sensitive troponin T and N-terminal pro B-type natriuretic peptide in prediction of short-term mortality after non-cardiac surgery (High-sensitive troponin T and N-terminal pro B-type natriuretuc peptide in prediciton of mortality after non-cardiac surgery) |
| title_fullStr | Preoperative high-sensitive troponin T and N-terminal pro B-type natriuretic peptide in prediction of short-term mortality after non-cardiac surgery (High-sensitive troponin T and N-terminal pro B-type natriuretuc peptide in prediciton of mortality after non-cardiac surgery) |
| title_full_unstemmed | Preoperative high-sensitive troponin T and N-terminal pro B-type natriuretic peptide in prediction of short-term mortality after non-cardiac surgery (High-sensitive troponin T and N-terminal pro B-type natriuretuc peptide in prediciton of mortality after non-cardiac surgery) |
| title_short | Preoperative high-sensitive troponin T and N-terminal pro B-type natriuretic peptide in prediction of short-term mortality after non-cardiac surgery (High-sensitive troponin T and N-terminal pro B-type natriuretuc peptide in prediciton of mortality after non-cardiac surgery) |
| title_sort | preoperative high sensitive troponin t and n terminal pro b type natriuretic peptide in prediction of short term mortality after non cardiac surgery high sensitive troponin t and n terminal pro b type natriuretuc peptide in prediciton of mortality after non cardiac surgery |
| topic | cardiac biomarkers short-term mortality perioperative risk non-cardiac surgery coronary artery disease |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2217-7744/2018/2217-77441808163S.pdf |
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