Fluvoxamine effectiveness in patients with various atrial fibrillations forms
Aim. To assess the effectiveness of depressive disorder (DD) treatment with fluvoxamine in patients with various forms of atrial fibrillation (AF), as well as to investigate fluvoxamine effects on AF clinical course. Material and methods. Group I included 51 patients with various forms of AF and DD,...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
1970-01-01
|
| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2162 |
| _version_ | 1797882789295554560 |
|---|---|
| author | R. V. Gorenkov O. G. Dvorina Yu. M. Pozdnyakov Yu. P. Zinchenko |
| author_facet | R. V. Gorenkov O. G. Dvorina Yu. M. Pozdnyakov Yu. P. Zinchenko |
| author_sort | R. V. Gorenkov |
| collection | DOAJ |
| description | Aim. To assess the effectiveness of depressive disorder (DD) treatment with fluvoxamine in patients with various forms of atrial fibrillation (AF), as well as to investigate fluvoxamine effects on AF clinical course. Material and methods. Group I included 51 patients with various forms of AF and DD, receiving fluvoxamine (50 mg once a day) for 6 months. Group II included 49 patients with AF and non-treated DD (comparison group). All participants received standard antiarrythmic therapy. At 6 months, the incidence of AF attacks and transition from tachycardic to normocardic AF, blood levels of fibrinogen, and depression severity (CES-D questionnaire) were assessed. Results. Three AF patients were withdrawn from fluvoxamine therapy at Week 1, due to adverse effects. In the other Group I patients (n=48), fluvoxamine reduced DD severity by 2,8 points on average (p<0,01). Fluvoxamine treatment was also associated with reduced AF attack incidence in 48,3±9,3 % of the patients with paroxysmal and persistent AF (p<0,01), and transition from tachycardic to normocardic AF in 47,4±11,5 % of the patients with permanent AF (p<0,05). The beneficial clinical effect (reduced DD severity, decreased AF attack incidence, reduced fibrinogen levels) was maximal in patients with paroxysmal and persistent AF, and minimal in patients with permanent AF, possibly due to more advanced heart failure and more severe clinical course of the disease. Conclusion. An antidepressant fluvoxamine reduces DD severity in AF patients and improves the clinical course of various AF forms. |
| first_indexed | 2024-04-10T03:41:18Z |
| format | Article |
| id | doaj.art-179f08f5c01049bea100c901c1a6af4e |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:41:18Z |
| publishDate | 1970-01-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-179f08f5c01049bea100c901c1a6af4e2023-03-13T07:23:10Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01251970-01-019749551871Fluvoxamine effectiveness in patients with various atrial fibrillations formsR. V. Gorenkov0O. G. Dvorina1Yu. M. Pozdnyakov2Yu. P. Zinchenko3ГУ Московский областной научно-исследовательский клинический институт им. М.Ф. ВладимирскогоГУ Московский областной научно-исследовательский клинический институт им. М.Ф. ВладимирскогоМУЗ “Жуковская городская клиническая больница”. Жуковский, Московская областьМосковский государственный университет им. М.В. Ломоносова. МоскваAim. To assess the effectiveness of depressive disorder (DD) treatment with fluvoxamine in patients with various forms of atrial fibrillation (AF), as well as to investigate fluvoxamine effects on AF clinical course. Material and methods. Group I included 51 patients with various forms of AF and DD, receiving fluvoxamine (50 mg once a day) for 6 months. Group II included 49 patients with AF and non-treated DD (comparison group). All participants received standard antiarrythmic therapy. At 6 months, the incidence of AF attacks and transition from tachycardic to normocardic AF, blood levels of fibrinogen, and depression severity (CES-D questionnaire) were assessed. Results. Three AF patients were withdrawn from fluvoxamine therapy at Week 1, due to adverse effects. In the other Group I patients (n=48), fluvoxamine reduced DD severity by 2,8 points on average (p<0,01). Fluvoxamine treatment was also associated with reduced AF attack incidence in 48,3±9,3 % of the patients with paroxysmal and persistent AF (p<0,01), and transition from tachycardic to normocardic AF in 47,4±11,5 % of the patients with permanent AF (p<0,05). The beneficial clinical effect (reduced DD severity, decreased AF attack incidence, reduced fibrinogen levels) was maximal in patients with paroxysmal and persistent AF, and minimal in patients with permanent AF, possibly due to more advanced heart failure and more severe clinical course of the disease. Conclusion. An antidepressant fluvoxamine reduces DD severity in AF patients and improves the clinical course of various AF forms.https://cardiovascular.elpub.ru/jour/article/view/2162фибрилляция предсердийдепрессивные расстройствалечениефлувоксамин |
| spellingShingle | R. V. Gorenkov O. G. Dvorina Yu. M. Pozdnyakov Yu. P. Zinchenko Fluvoxamine effectiveness in patients with various atrial fibrillations forms Кардиоваскулярная терапия и профилактика фибрилляция предсердий депрессивные расстройства лечение флувоксамин |
| title | Fluvoxamine effectiveness in patients with various atrial fibrillations forms |
| title_full | Fluvoxamine effectiveness in patients with various atrial fibrillations forms |
| title_fullStr | Fluvoxamine effectiveness in patients with various atrial fibrillations forms |
| title_full_unstemmed | Fluvoxamine effectiveness in patients with various atrial fibrillations forms |
| title_short | Fluvoxamine effectiveness in patients with various atrial fibrillations forms |
| title_sort | fluvoxamine effectiveness in patients with various atrial fibrillations forms |
| topic | фибрилляция предсердий депрессивные расстройства лечение флувоксамин |
| url | https://cardiovascular.elpub.ru/jour/article/view/2162 |
| work_keys_str_mv | AT rvgorenkov fluvoxamineeffectivenessinpatientswithvariousatrialfibrillationsforms AT ogdvorina fluvoxamineeffectivenessinpatientswithvariousatrialfibrillationsforms AT yumpozdnyakov fluvoxamineeffectivenessinpatientswithvariousatrialfibrillationsforms AT yupzinchenko fluvoxamineeffectivenessinpatientswithvariousatrialfibrillationsforms |