Effects of Chinese Herbal Medicines on the Risk of Overall Mortality, Readmission, and Reoperation in Hip Fracture Patients
Hip fracture is a major public health concern, with high incidence rates in the elderly worldwide. Hip fractures are associated with increased medical costs, patient dependency on families, and higher rates of morbidity and mortality. Chinese herbal medicine (CHM) is typically characterized as cost-...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.00629/full |
| _version_ | 1818970324747681792 |
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| author | Chi-Fung Cheng Chi-Fung Cheng Ying-Ju Lin Ying-Ju Lin Fuu-Jen Tsai Fuu-Jen Tsai Fuu-Jen Tsai Te-Mao Li Ting-Hsu Lin Chiu-Chu Liao Shao-Mei Huang Xiang Liu Ming-Ju Li Bo Ban Wen-Miin Liang Jeff Chien-Fu Lin Jeff Chien-Fu Lin |
| author_facet | Chi-Fung Cheng Chi-Fung Cheng Ying-Ju Lin Ying-Ju Lin Fuu-Jen Tsai Fuu-Jen Tsai Fuu-Jen Tsai Te-Mao Li Ting-Hsu Lin Chiu-Chu Liao Shao-Mei Huang Xiang Liu Ming-Ju Li Bo Ban Wen-Miin Liang Jeff Chien-Fu Lin Jeff Chien-Fu Lin |
| author_sort | Chi-Fung Cheng |
| collection | DOAJ |
| description | Hip fracture is a major public health concern, with high incidence rates in the elderly worldwide. Hip fractures are associated with increased medical costs, patient dependency on families, and higher rates of morbidity and mortality. Chinese herbal medicine (CHM) is typically characterized as cost-effective and suitable for long-term use with few side effects. To better understand the effects of CHM on hip fracture patients, we utilized a population-based database to investigate the demographic characteristics, cumulative incidence of overall mortality, readmission, reoperation, and patterns of CHM prescription. We found that CHM usage was associated with a lower risk of overall mortality [P = 0.0009; adjusted hazard ratio (HR): 0.47, 95% confidence interval (CI): 0.30–0.73], readmission (P = 0.0345; adjusted HR: 0.67, 95% CI: 0.46–0.97), and reoperation (P = 0.0009; adjusted HR: 0.57, 95% CI: 0.40–0.79) after adjustment for age, type of hip fracture, surgical treatment type, and comorbidities. We also identified the herbal formulas, single herbs, and prescription patterns for the treatment of hip fracture by using association rule mining and network analysis. For hip fracture patients, the most common CHM coprescription pattern was Du-Zhong (DZ) → Xu-Duan (XD), followed by Du-Huo-Ji-Sheng-Tang (DHJST) → Shu-Jing-Huo-Xue-Tang (SJHXT), and Gu-Sui-Bu (GSB) → Xu-Duan (XD). Furthermore, XD was the core prescription, and DZ, GSB, SJHXT, and DHJST were important prescriptions located in cluster 1 of the prescription patterns. This study provides evidence for clinical CHM use as an adjunctive therapy that offers benefits to hip fracture patients. |
| first_indexed | 2024-12-20T14:34:40Z |
| format | Article |
| id | doaj.art-179f6cdd44b241409722e109d0dac4c0 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-20T14:34:40Z |
| publishDate | 2019-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-179f6cdd44b241409722e109d0dac4c02022-12-21T19:37:29ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-06-011010.3389/fphar.2019.00629431544Effects of Chinese Herbal Medicines on the Risk of Overall Mortality, Readmission, and Reoperation in Hip Fracture PatientsChi-Fung Cheng0Chi-Fung Cheng1Ying-Ju Lin2Ying-Ju Lin3Fuu-Jen Tsai4Fuu-Jen Tsai5Fuu-Jen Tsai6Te-Mao Li7Ting-Hsu Lin8Chiu-Chu Liao9Shao-Mei Huang10Xiang Liu11Ming-Ju Li12Bo Ban13Wen-Miin Liang14Jeff Chien-Fu Lin15Jeff Chien-Fu Lin16Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, TaiwanGraduate Institute of Biostatistics, School of Public Health, China Medical University, Taichung, TaiwanGenetic Center, Department of Medical Research, China Medical University Hospital, Taichung, TaiwanSchool of Chinese Medicine, China Medical University, Taichung, TaiwanGenetic Center, Department of Medical Research, China Medical University Hospital, Taichung, TaiwanSchool of Chinese Medicine, China Medical University, Taichung, TaiwanDepartment of Biotechnology and Bioinformatics, Asia University, Taichung, TaiwanSchool of Chinese Medicine, China Medical University, Taichung, TaiwanGenetic Center, Department of Medical Research, China Medical University Hospital, Taichung, TaiwanGenetic Center, Department of Medical Research, China Medical University Hospital, Taichung, TaiwanGenetic Center, Department of Medical Research, China Medical University Hospital, Taichung, TaiwanNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United StatesGraduate Institute of Biostatistics, School of Public Health, China Medical University, Taichung, TaiwanChinese Research Center for Behavior Medicine in Growth and Development, Jining, ChinaGraduate Institute of Biostatistics, School of Public Health, China Medical University, Taichung, TaiwanDepartment of Statistics, National Taipei University, Taipei, TaiwanDepartment of Orthopedic Surgery, Wan Fang Hospital, Taipei Medical University, Taipei, TaiwanHip fracture is a major public health concern, with high incidence rates in the elderly worldwide. Hip fractures are associated with increased medical costs, patient dependency on families, and higher rates of morbidity and mortality. Chinese herbal medicine (CHM) is typically characterized as cost-effective and suitable for long-term use with few side effects. To better understand the effects of CHM on hip fracture patients, we utilized a population-based database to investigate the demographic characteristics, cumulative incidence of overall mortality, readmission, reoperation, and patterns of CHM prescription. We found that CHM usage was associated with a lower risk of overall mortality [P = 0.0009; adjusted hazard ratio (HR): 0.47, 95% confidence interval (CI): 0.30–0.73], readmission (P = 0.0345; adjusted HR: 0.67, 95% CI: 0.46–0.97), and reoperation (P = 0.0009; adjusted HR: 0.57, 95% CI: 0.40–0.79) after adjustment for age, type of hip fracture, surgical treatment type, and comorbidities. We also identified the herbal formulas, single herbs, and prescription patterns for the treatment of hip fracture by using association rule mining and network analysis. For hip fracture patients, the most common CHM coprescription pattern was Du-Zhong (DZ) → Xu-Duan (XD), followed by Du-Huo-Ji-Sheng-Tang (DHJST) → Shu-Jing-Huo-Xue-Tang (SJHXT), and Gu-Sui-Bu (GSB) → Xu-Duan (XD). Furthermore, XD was the core prescription, and DZ, GSB, SJHXT, and DHJST were important prescriptions located in cluster 1 of the prescription patterns. This study provides evidence for clinical CHM use as an adjunctive therapy that offers benefits to hip fracture patients.https://www.frontiersin.org/article/10.3389/fphar.2019.00629/fullhip fractureChinese herbal medicineoverall mortalityreadmissionreoperation |
| spellingShingle | Chi-Fung Cheng Chi-Fung Cheng Ying-Ju Lin Ying-Ju Lin Fuu-Jen Tsai Fuu-Jen Tsai Fuu-Jen Tsai Te-Mao Li Ting-Hsu Lin Chiu-Chu Liao Shao-Mei Huang Xiang Liu Ming-Ju Li Bo Ban Wen-Miin Liang Jeff Chien-Fu Lin Jeff Chien-Fu Lin Effects of Chinese Herbal Medicines on the Risk of Overall Mortality, Readmission, and Reoperation in Hip Fracture Patients Frontiers in Pharmacology hip fracture Chinese herbal medicine overall mortality readmission reoperation |
| title | Effects of Chinese Herbal Medicines on the Risk of Overall Mortality, Readmission, and Reoperation in Hip Fracture Patients |
| title_full | Effects of Chinese Herbal Medicines on the Risk of Overall Mortality, Readmission, and Reoperation in Hip Fracture Patients |
| title_fullStr | Effects of Chinese Herbal Medicines on the Risk of Overall Mortality, Readmission, and Reoperation in Hip Fracture Patients |
| title_full_unstemmed | Effects of Chinese Herbal Medicines on the Risk of Overall Mortality, Readmission, and Reoperation in Hip Fracture Patients |
| title_short | Effects of Chinese Herbal Medicines on the Risk of Overall Mortality, Readmission, and Reoperation in Hip Fracture Patients |
| title_sort | effects of chinese herbal medicines on the risk of overall mortality readmission and reoperation in hip fracture patients |
| topic | hip fracture Chinese herbal medicine overall mortality readmission reoperation |
| url | https://www.frontiersin.org/article/10.3389/fphar.2019.00629/full |
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