α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes

Summary: Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of C-peptide long after disease onset but develop an inadequate glucagon response to hypoglycemia following T1D diagnosis. The features of these residual β cells and α cells in the islet endocrine compart...

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Main Authors: Marcela Brissova, Rachana Haliyur, Diane Saunders, Shristi Shrestha, Chunhua Dai, David M. Blodgett, Rita Bottino, Martha Campbell-Thompson, Radhika Aramandla, Gregory Poffenberger, Jill Lindner, Fong Cheng Pan, Matthias G. von Herrath, Dale L. Greiner, Leonard D. Shultz, May Sanyoura, Louis H. Philipson, Mark Atkinson, David M. Harlan, Shawn E. Levy, Nripesh Prasad, Roland Stein, Alvin C. Powers
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718302134

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