DNA lesions triggered by visible light in skin cells: In the search for comprehensive sun protection
Skin cells present many endogenous photosensitizers (ePS) that interact with light, generating oxidizing species, causing molecular damage in proteins, lipids, and nucleic acids, and consequently triggering cellular and organelle malfunction. Several cell lines with terminal differentiation are susc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Journal of Photochemistry and Photobiology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666469023000581 |
| _version_ | 1797405352492269568 |
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| author | Paulo Newton Tonolli Orlando Chiarelli-Neto Maurício S. Baptista |
| author_facet | Paulo Newton Tonolli Orlando Chiarelli-Neto Maurício S. Baptista |
| author_sort | Paulo Newton Tonolli |
| collection | DOAJ |
| description | Skin cells present many endogenous photosensitizers (ePS) that interact with light, generating oxidizing species, causing molecular damage in proteins, lipids, and nucleic acids, and consequently triggering cellular and organelle malfunction. Several cell lines with terminal differentiation are susceptible to accumulating non-digestible pigments, such as lipofuscin or melanin-lipofuscin. Besides being hallmarks of aging, both pigments can work as photosensitizers, increasing and expanding the toxicity of sunlight to the range of visible light (VL, 400–700 nm). In here we review the literature to describe the mechanisms by which the photosensitized oxidation reactions induced by VL cause DNA damage. We aim to provide the mechanistic background needed to improve the current strategies of photoprotection. |
| first_indexed | 2024-03-09T03:08:42Z |
| format | Article |
| id | doaj.art-17a193feb7dd436da26f29604d14dc24 |
| institution | Directory Open Access Journal |
| issn | 2666-4690 |
| language | English |
| last_indexed | 2024-03-09T03:08:42Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Photochemistry and Photobiology |
| spelling | doaj.art-17a193feb7dd436da26f29604d14dc242023-12-04T05:24:15ZengElsevierJournal of Photochemistry and Photobiology2666-46902023-12-0118100217DNA lesions triggered by visible light in skin cells: In the search for comprehensive sun protectionPaulo Newton Tonolli0Orlando Chiarelli-Neto1Maurício S. Baptista2Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, BrazilFaculty of Medicine, University Center of Espírito Santo, Colatina, ES, Brazil; Corresponding author.Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, BrazilSkin cells present many endogenous photosensitizers (ePS) that interact with light, generating oxidizing species, causing molecular damage in proteins, lipids, and nucleic acids, and consequently triggering cellular and organelle malfunction. Several cell lines with terminal differentiation are susceptible to accumulating non-digestible pigments, such as lipofuscin or melanin-lipofuscin. Besides being hallmarks of aging, both pigments can work as photosensitizers, increasing and expanding the toxicity of sunlight to the range of visible light (VL, 400–700 nm). In here we review the literature to describe the mechanisms by which the photosensitized oxidation reactions induced by VL cause DNA damage. We aim to provide the mechanistic background needed to improve the current strategies of photoprotection.http://www.sciencedirect.com/science/article/pii/S2666469023000581MelaninMelanocytesLipofuscinKeratinocytesPhotoprotectionPhotodamage |
| spellingShingle | Paulo Newton Tonolli Orlando Chiarelli-Neto Maurício S. Baptista DNA lesions triggered by visible light in skin cells: In the search for comprehensive sun protection Journal of Photochemistry and Photobiology Melanin Melanocytes Lipofuscin Keratinocytes Photoprotection Photodamage |
| title | DNA lesions triggered by visible light in skin cells: In the search for comprehensive sun protection |
| title_full | DNA lesions triggered by visible light in skin cells: In the search for comprehensive sun protection |
| title_fullStr | DNA lesions triggered by visible light in skin cells: In the search for comprehensive sun protection |
| title_full_unstemmed | DNA lesions triggered by visible light in skin cells: In the search for comprehensive sun protection |
| title_short | DNA lesions triggered by visible light in skin cells: In the search for comprehensive sun protection |
| title_sort | dna lesions triggered by visible light in skin cells in the search for comprehensive sun protection |
| topic | Melanin Melanocytes Lipofuscin Keratinocytes Photoprotection Photodamage |
| url | http://www.sciencedirect.com/science/article/pii/S2666469023000581 |
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