Experimental Data-Mining Analyses Reveal New Roles of Low-Intensity Ultrasound in Differentiating Cell Death Regulatome in Cancer and Non-cancer Cells via Potential Modulation of Chromatin Long-Range Interactions
Background: The mechanisms underlying low intensity ultrasound (LIUS) mediated suppression of inflammation and tumorigenesis remain poorly determined.Methods: We used microarray datasets from NCBI GEO Dataset databases and conducted a comprehensive data mining analyses, where we studied the gene exp...
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.00600/full |
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| author | Jiwei Wang Jiwei Wang Jiwei Wang Jiwei Wang Bin Lai Bin Lai Bin Lai Bin Lai Gayani Nanayakkara Gayani Nanayakkara Gayani Nanayakkara Qian Yang Qian Yang Qian Yang Yu Sun Yu Sun Yu Sun Yifan Lu Yifan Lu Yifan Lu Ying Shao Ying Shao Ying Shao Daohai Yu William Y. Yang William Y. Yang William Y. Yang Ramon Cueto Ramon Cueto Ramon Cueto Hangfei Fu Hangfei Fu Hangfei Fu Huihong Zeng Huihong Zeng Huihong Zeng Wen Shen Wen Shen Wen Shen Susu Wu Susu Wu Susu Wu Chunquan Zhang Yanna Liu Eric T. Choi Eric T. Choi Eric T. Choi Eric T. Choi Hong Wang Hong Wang Hong Wang Xiaofeng Yang Xiaofeng Yang Xiaofeng Yang |
| author_facet | Jiwei Wang Jiwei Wang Jiwei Wang Jiwei Wang Bin Lai Bin Lai Bin Lai Bin Lai Gayani Nanayakkara Gayani Nanayakkara Gayani Nanayakkara Qian Yang Qian Yang Qian Yang Yu Sun Yu Sun Yu Sun Yifan Lu Yifan Lu Yifan Lu Ying Shao Ying Shao Ying Shao Daohai Yu William Y. Yang William Y. Yang William Y. Yang Ramon Cueto Ramon Cueto Ramon Cueto Hangfei Fu Hangfei Fu Hangfei Fu Huihong Zeng Huihong Zeng Huihong Zeng Wen Shen Wen Shen Wen Shen Susu Wu Susu Wu Susu Wu Chunquan Zhang Yanna Liu Eric T. Choi Eric T. Choi Eric T. Choi Eric T. Choi Hong Wang Hong Wang Hong Wang Xiaofeng Yang Xiaofeng Yang Xiaofeng Yang |
| author_sort | Jiwei Wang |
| collection | DOAJ |
| description | Background: The mechanisms underlying low intensity ultrasound (LIUS) mediated suppression of inflammation and tumorigenesis remain poorly determined.Methods: We used microarray datasets from NCBI GEO Dataset databases and conducted a comprehensive data mining analyses, where we studied the gene expression of 299 cell death regulators that regulate 13 different cell death types (cell death regulatome) in cells treated with LIUS.Results: We made the following findings: (1) LIUS exerts a profound effect on the expression of cell death regulatome in cancer cells and non-cancer cells. Of note, LIUS has the tendency to downregulate the gene expression of cell death regulators in non-cancer cells. Most of the cell death regulator genes downregulated by LIUS in non-cancer cells are responsible for mediating inflammatory signaling pathways; (2) LIUS activates different cell death transcription factors in cancer and non-cancer cells. Transcription factors TP-53 and SRF- were induced by LIUS exposure in cancer cells and non-cancer cells, respectively; (3) As two well-accepted mechanisms of LIUS, mild hyperthermia and oscillatory shear stress induce changes in the expression of cell death regulators, therefore, may be responsible for inducing LIUS mediated changes in gene expression patterns of cell death regulators in cells; (4) LIUS exposure may change the redox status of the cells. LIUS may induce more of antioxidant effects in non-cancer cells compared to cancer cells; and (5) The genes modulated by LIUS in cancer cells have distinct chromatin long range interaction (CLRI) patterns to that of non-cancer cells.Conclusions: Our analysis suggests novel molecular mechanisms that may be utilized by LIUS to induce tumor suppression and inflammation inhibition. Our findings may lead to development of new treatment protocols for cancers and chronic inflammation. |
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| publishDate | 2019-07-01 |
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| series | Frontiers in Oncology |
| spelling | doaj.art-17a21c21901a46bfad1b2be1fa38ca172022-12-21T17:33:42ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-07-01910.3389/fonc.2019.00600448256Experimental Data-Mining Analyses Reveal New Roles of Low-Intensity Ultrasound in Differentiating Cell Death Regulatome in Cancer and Non-cancer Cells via Potential Modulation of Chromatin Long-Range InteractionsJiwei Wang0Jiwei Wang1Jiwei Wang2Jiwei Wang3Bin Lai4Bin Lai5Bin Lai6Bin Lai7Gayani Nanayakkara8Gayani Nanayakkara9Gayani Nanayakkara10Qian Yang11Qian Yang12Qian Yang13Yu Sun14Yu Sun15Yu Sun16Yifan Lu17Yifan Lu18Yifan Lu19Ying Shao20Ying Shao21Ying Shao22Daohai Yu23William Y. Yang24William Y. Yang25William Y. Yang26Ramon Cueto27Ramon Cueto28Ramon Cueto29Hangfei Fu30Hangfei Fu31Hangfei Fu32Huihong Zeng33Huihong Zeng34Huihong Zeng35Wen Shen36Wen Shen37Wen Shen38Susu Wu39Susu Wu40Susu Wu41Chunquan Zhang42Yanna Liu43Eric T. Choi44Eric T. Choi45Eric T. Choi46Eric T. Choi47Hong Wang48Hong Wang49Hong Wang50Xiaofeng Yang51Xiaofeng Yang52Xiaofeng Yang53Department of Pharmacology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Microbiology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Immunology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Ultrasound, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Pharmacology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Microbiology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Immunology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Pharmacology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Microbiology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Immunology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Pharmacology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Microbiology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Immunology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Pharmacology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Microbiology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Immunology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Pharmacology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Microbiology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Immunology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Pharmacology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Microbiology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Immunology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Clinical Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United StatesDepartment of Pharmacology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Microbiology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Immunology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Pharmacology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Microbiology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Immunology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Pharmacology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Microbiology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Immunology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Pharmacology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Microbiology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Immunology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Pharmacology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Microbiology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Immunology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Pharmacology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Microbiology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Immunology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Ultrasound, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Ultrasound, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Pharmacology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Microbiology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Immunology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDivision of Vascular and Endovascular Surgery, Department of Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United StatesDepartment of Pharmacology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Microbiology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Immunology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Pharmacology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Microbiology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesDepartment of Immunology, Centers for Metabolic Disease Research, Inflammation, Translational and Clinical Lung Research, Cardiovascular Research, Thrombosis Research, Philadelphia, PA, United StatesBackground: The mechanisms underlying low intensity ultrasound (LIUS) mediated suppression of inflammation and tumorigenesis remain poorly determined.Methods: We used microarray datasets from NCBI GEO Dataset databases and conducted a comprehensive data mining analyses, where we studied the gene expression of 299 cell death regulators that regulate 13 different cell death types (cell death regulatome) in cells treated with LIUS.Results: We made the following findings: (1) LIUS exerts a profound effect on the expression of cell death regulatome in cancer cells and non-cancer cells. Of note, LIUS has the tendency to downregulate the gene expression of cell death regulators in non-cancer cells. Most of the cell death regulator genes downregulated by LIUS in non-cancer cells are responsible for mediating inflammatory signaling pathways; (2) LIUS activates different cell death transcription factors in cancer and non-cancer cells. Transcription factors TP-53 and SRF- were induced by LIUS exposure in cancer cells and non-cancer cells, respectively; (3) As two well-accepted mechanisms of LIUS, mild hyperthermia and oscillatory shear stress induce changes in the expression of cell death regulators, therefore, may be responsible for inducing LIUS mediated changes in gene expression patterns of cell death regulators in cells; (4) LIUS exposure may change the redox status of the cells. LIUS may induce more of antioxidant effects in non-cancer cells compared to cancer cells; and (5) The genes modulated by LIUS in cancer cells have distinct chromatin long range interaction (CLRI) patterns to that of non-cancer cells.Conclusions: Our analysis suggests novel molecular mechanisms that may be utilized by LIUS to induce tumor suppression and inflammation inhibition. Our findings may lead to development of new treatment protocols for cancers and chronic inflammation.https://www.frontiersin.org/article/10.3389/fonc.2019.00600/fullultrasoundcell death regulatorsinflammatory pathwayscancer therapychromatin long-range interaction |
| spellingShingle | Jiwei Wang Jiwei Wang Jiwei Wang Jiwei Wang Bin Lai Bin Lai Bin Lai Bin Lai Gayani Nanayakkara Gayani Nanayakkara Gayani Nanayakkara Qian Yang Qian Yang Qian Yang Yu Sun Yu Sun Yu Sun Yifan Lu Yifan Lu Yifan Lu Ying Shao Ying Shao Ying Shao Daohai Yu William Y. Yang William Y. Yang William Y. Yang Ramon Cueto Ramon Cueto Ramon Cueto Hangfei Fu Hangfei Fu Hangfei Fu Huihong Zeng Huihong Zeng Huihong Zeng Wen Shen Wen Shen Wen Shen Susu Wu Susu Wu Susu Wu Chunquan Zhang Yanna Liu Eric T. Choi Eric T. Choi Eric T. Choi Eric T. Choi Hong Wang Hong Wang Hong Wang Xiaofeng Yang Xiaofeng Yang Xiaofeng Yang Experimental Data-Mining Analyses Reveal New Roles of Low-Intensity Ultrasound in Differentiating Cell Death Regulatome in Cancer and Non-cancer Cells via Potential Modulation of Chromatin Long-Range Interactions Frontiers in Oncology ultrasound cell death regulators inflammatory pathways cancer therapy chromatin long-range interaction |
| title | Experimental Data-Mining Analyses Reveal New Roles of Low-Intensity Ultrasound in Differentiating Cell Death Regulatome in Cancer and Non-cancer Cells via Potential Modulation of Chromatin Long-Range Interactions |
| title_full | Experimental Data-Mining Analyses Reveal New Roles of Low-Intensity Ultrasound in Differentiating Cell Death Regulatome in Cancer and Non-cancer Cells via Potential Modulation of Chromatin Long-Range Interactions |
| title_fullStr | Experimental Data-Mining Analyses Reveal New Roles of Low-Intensity Ultrasound in Differentiating Cell Death Regulatome in Cancer and Non-cancer Cells via Potential Modulation of Chromatin Long-Range Interactions |
| title_full_unstemmed | Experimental Data-Mining Analyses Reveal New Roles of Low-Intensity Ultrasound in Differentiating Cell Death Regulatome in Cancer and Non-cancer Cells via Potential Modulation of Chromatin Long-Range Interactions |
| title_short | Experimental Data-Mining Analyses Reveal New Roles of Low-Intensity Ultrasound in Differentiating Cell Death Regulatome in Cancer and Non-cancer Cells via Potential Modulation of Chromatin Long-Range Interactions |
| title_sort | experimental data mining analyses reveal new roles of low intensity ultrasound in differentiating cell death regulatome in cancer and non cancer cells via potential modulation of chromatin long range interactions |
| topic | ultrasound cell death regulators inflammatory pathways cancer therapy chromatin long-range interaction |
| url | https://www.frontiersin.org/article/10.3389/fonc.2019.00600/full |
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