TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage
The vertebrate TATA-binding protein (TBP) paralogue (TBPL2) is only expressed in growing oocytes, where TBP is absent. Here the authors highlight a unique role for the TBPL2/TFIIA complex in the establishment of the oocyte transcriptome by using a specific TSS recognition code.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20239-4 |
| _version_ | 1818841828534779904 |
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| author | Changwei Yu Nevena Cvetesic Vincent Hisler Kapil Gupta Tao Ye Emese Gazdag Luc Negroni Petra Hajkova Imre Berger Boris Lenhard Ferenc Müller Stéphane D. Vincent László Tora |
| author_facet | Changwei Yu Nevena Cvetesic Vincent Hisler Kapil Gupta Tao Ye Emese Gazdag Luc Negroni Petra Hajkova Imre Berger Boris Lenhard Ferenc Müller Stéphane D. Vincent László Tora |
| author_sort | Changwei Yu |
| collection | DOAJ |
| description | The vertebrate TATA-binding protein (TBP) paralogue (TBPL2) is only expressed in growing oocytes, where TBP is absent. Here the authors highlight a unique role for the TBPL2/TFIIA complex in the establishment of the oocyte transcriptome by using a specific TSS recognition code. |
| first_indexed | 2024-12-19T04:32:17Z |
| format | Article |
| id | doaj.art-17a2545846504f2fb6572d460793c1a3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:32:17Z |
| publishDate | 2020-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-17a2545846504f2fb6572d460793c1a32022-12-21T20:35:51ZengNature PortfolioNature Communications2041-17232020-12-0111111310.1038/s41467-020-20239-4TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usageChangwei Yu0Nevena Cvetesic1Vincent Hisler2Kapil Gupta3Tao Ye4Emese Gazdag5Luc Negroni6Petra Hajkova7Imre Berger8Boris Lenhard9Ferenc Müller10Stéphane D. Vincent11László Tora12Institut de Génétique et de Biologie Moléculaire et CellulaireImperial College London, South Kensington CampusInstitut de Génétique et de Biologie Moléculaire et CellulaireMax Planck Bristol Centre for Minimal Biology, University of Bristol, Cantock’s CloseInstitut de Génétique et de Biologie Moléculaire et CellulaireInstitut de Génétique et de Biologie Moléculaire et CellulaireInstitut de Génétique et de Biologie Moléculaire et CellulaireImperial College London, South Kensington CampusMax Planck Bristol Centre for Minimal Biology, University of Bristol, Cantock’s CloseImperial College London, South Kensington CampusInstitute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of BirminghamInstitut de Génétique et de Biologie Moléculaire et CellulaireInstitut de Génétique et de Biologie Moléculaire et CellulaireThe vertebrate TATA-binding protein (TBP) paralogue (TBPL2) is only expressed in growing oocytes, where TBP is absent. Here the authors highlight a unique role for the TBPL2/TFIIA complex in the establishment of the oocyte transcriptome by using a specific TSS recognition code.https://doi.org/10.1038/s41467-020-20239-4 |
| spellingShingle | Changwei Yu Nevena Cvetesic Vincent Hisler Kapil Gupta Tao Ye Emese Gazdag Luc Negroni Petra Hajkova Imre Berger Boris Lenhard Ferenc Müller Stéphane D. Vincent László Tora TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage Nature Communications |
| title | TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage |
| title_full | TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage |
| title_fullStr | TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage |
| title_full_unstemmed | TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage |
| title_short | TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage |
| title_sort | tbpl2 tfiia complex establishes the maternal transcriptome through oocyte specific promoter usage |
| url | https://doi.org/10.1038/s41467-020-20239-4 |
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