Could Pro-Inflammatory Cytokines Levels IL-6, IL-8, TNFα, Total Antioxidant Status and Lactate Dehydrogenase Be Associated with Peri-Implant Bone Loss? A Pilot Study
Background: The mechanisms of periimplantitis are mostly based on biofilm-induced inflammatory lesions around dental implants. However, the host reaction, reflected by the intensity of the inflammatory response to bacterial products, is crucial for peri-implant bone destruction. The aim of this pilo...
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MDPI AG
2021-11-01
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| Online Access: | https://www.mdpi.com/2076-3417/11/22/11012 |
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| author | Sergiu Drafta Dragos Mihai Guita Corina Marilena Cristache Irina Adriana Beuran Mihai Burlibasa Alexandru Eugen Petre Liliana Burlibasa |
| author_facet | Sergiu Drafta Dragos Mihai Guita Corina Marilena Cristache Irina Adriana Beuran Mihai Burlibasa Alexandru Eugen Petre Liliana Burlibasa |
| author_sort | Sergiu Drafta |
| collection | DOAJ |
| description | Background: The mechanisms of periimplantitis are mostly based on biofilm-induced inflammatory lesions around dental implants. However, the host reaction, reflected by the intensity of the inflammatory response to bacterial products, is crucial for peri-implant bone destruction. The aim of this pilot study was to measure total antioxidant status (TAS), the amount of IL-6, IL-8 and TNF-α (tumor necrosis factor), salivary lactate dehydrogenase (LDH) levels and the correlation with one-year peri-implant bone loss. Methods: Seven consecutive patients (Group 1), with the presence of at least one prior inserted dental implant, and three healthy individuals, fully dentate (Group 0), were enrolled. IL-6, IL-8, TNF-α, TAS and LDH were determined in saliva of both groups. Peri-implant marginal bone loss (MBL) at one year compared to baseline was evaluated for Group 1. Results: A statistically significant positive correlation was found in Group 1 between MBL and the IL-8 (<i>p</i> = 0.033) and a strong negative correlation between MBL and TAS (<i>p</i> = 0.002), but no statistically significant differences of the assessed parameters were found between the two groups. Conclusions: In the limits of the present preliminary study, salivary TAS and proinflammatory cytokines could be associated with the risk of peri-implant bone loss over time. |
| first_indexed | 2024-03-10T05:42:56Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T05:42:56Z |
| publishDate | 2021-11-01 |
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| series | Applied Sciences |
| spelling | doaj.art-17a34487d1a1417ba2368755c5393e412023-11-22T22:22:20ZengMDPI AGApplied Sciences2076-34172021-11-0111221101210.3390/app112211012Could Pro-Inflammatory Cytokines Levels IL-6, IL-8, TNFα, Total Antioxidant Status and Lactate Dehydrogenase Be Associated with Peri-Implant Bone Loss? A Pilot StudySergiu Drafta0Dragos Mihai Guita1Corina Marilena Cristache2Irina Adriana Beuran3Mihai Burlibasa4Alexandru Eugen Petre5Liliana Burlibasa6Department of Fixed Dental Prosthetics and Occlusion, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, 19 Plevnei Ave., 010221 Bucharest, RomaniaWhite Dental Clinic, 190B Calea Bucuresti, 117715 Stefanesti, RomaniaDepartment of Dental Techniques, Faculty of Midwifery and Medical Assisting (FMAM), “Carol Davila” University of Medicine and Pharmacy, 8, Eroilor Sanitari Blvd, 050474 Bucharest, RomaniaDepartment of Orthodontic and Dento-Facial Orthopedics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, 19 Plevnei Ave., 010221 Bucharest, RomaniaDepartment of Dental Techniques, Faculty of Midwifery and Medical Assisting (FMAM), “Carol Davila” University of Medicine and Pharmacy, 8, Eroilor Sanitari Blvd, 050474 Bucharest, RomaniaDepartment of Fixed Dental Prosthetics and Occlusion, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, 19 Plevnei Ave., 010221 Bucharest, RomaniaGenetics Department, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, RomaniaBackground: The mechanisms of periimplantitis are mostly based on biofilm-induced inflammatory lesions around dental implants. However, the host reaction, reflected by the intensity of the inflammatory response to bacterial products, is crucial for peri-implant bone destruction. The aim of this pilot study was to measure total antioxidant status (TAS), the amount of IL-6, IL-8 and TNF-α (tumor necrosis factor), salivary lactate dehydrogenase (LDH) levels and the correlation with one-year peri-implant bone loss. Methods: Seven consecutive patients (Group 1), with the presence of at least one prior inserted dental implant, and three healthy individuals, fully dentate (Group 0), were enrolled. IL-6, IL-8, TNF-α, TAS and LDH were determined in saliva of both groups. Peri-implant marginal bone loss (MBL) at one year compared to baseline was evaluated for Group 1. Results: A statistically significant positive correlation was found in Group 1 between MBL and the IL-8 (<i>p</i> = 0.033) and a strong negative correlation between MBL and TAS (<i>p</i> = 0.002), but no statistically significant differences of the assessed parameters were found between the two groups. Conclusions: In the limits of the present preliminary study, salivary TAS and proinflammatory cytokines could be associated with the risk of peri-implant bone loss over time.https://www.mdpi.com/2076-3417/11/22/11012salivary biomarkermarginal bone lossperiimplantitistotal antioxidant status |
| spellingShingle | Sergiu Drafta Dragos Mihai Guita Corina Marilena Cristache Irina Adriana Beuran Mihai Burlibasa Alexandru Eugen Petre Liliana Burlibasa Could Pro-Inflammatory Cytokines Levels IL-6, IL-8, TNFα, Total Antioxidant Status and Lactate Dehydrogenase Be Associated with Peri-Implant Bone Loss? A Pilot Study Applied Sciences salivary biomarker marginal bone loss periimplantitis total antioxidant status |
| title | Could Pro-Inflammatory Cytokines Levels IL-6, IL-8, TNFα, Total Antioxidant Status and Lactate Dehydrogenase Be Associated with Peri-Implant Bone Loss? A Pilot Study |
| title_full | Could Pro-Inflammatory Cytokines Levels IL-6, IL-8, TNFα, Total Antioxidant Status and Lactate Dehydrogenase Be Associated with Peri-Implant Bone Loss? A Pilot Study |
| title_fullStr | Could Pro-Inflammatory Cytokines Levels IL-6, IL-8, TNFα, Total Antioxidant Status and Lactate Dehydrogenase Be Associated with Peri-Implant Bone Loss? A Pilot Study |
| title_full_unstemmed | Could Pro-Inflammatory Cytokines Levels IL-6, IL-8, TNFα, Total Antioxidant Status and Lactate Dehydrogenase Be Associated with Peri-Implant Bone Loss? A Pilot Study |
| title_short | Could Pro-Inflammatory Cytokines Levels IL-6, IL-8, TNFα, Total Antioxidant Status and Lactate Dehydrogenase Be Associated with Peri-Implant Bone Loss? A Pilot Study |
| title_sort | could pro inflammatory cytokines levels il 6 il 8 tnfα total antioxidant status and lactate dehydrogenase be associated with peri implant bone loss a pilot study |
| topic | salivary biomarker marginal bone loss periimplantitis total antioxidant status |
| url | https://www.mdpi.com/2076-3417/11/22/11012 |
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