SENSITIVITY AND SPECIFICITY OF URINARY BLADDER CANCER ANTIGEN FOR DIAGNOSIS OF BLADDER TUMOR;A COMPARATIVE STUDY WITH URINARY CYTOLOGY
Cystoscopy and urinary cytology are currently the basis for diagnosis and follow-up of bladder tumors. Research to find a sensitive and specific tumor marker for diagnosis of bladder tumor is actively underway, however, due to low sensitivity and high cost of cytology. This cross-sectional study...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2005-06-01
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| Series: | Acta Medica Iranica |
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| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/2041.pdf&manuscript_id=2041 |
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| author | K. Radkhah M. R. Nowroozi P. Jabalameli |
| author_facet | K. Radkhah M. R. Nowroozi P. Jabalameli |
| author_sort | K. Radkhah |
| collection | DOAJ |
| description | Cystoscopy and urinary cytology are currently the basis for diagnosis and follow-up of bladder tumors. Research to find a sensitive and specific tumor marker for diagnosis of bladder tumor is actively underway, however, due to low sensitivity and high cost of cytology. This cross-sectional study was performed in 65 patients to evaluate whether urinary bladder cancer (UBC) antigen level can predict the presence of active bladder tumor. In patients with inactive tumor, UBC antigen level was determined in addition to standard cystoscopy and cytology for follow-up. Patients with active tumor were subjected to standard treatment and UBC antigen level determination. UBC antigen levels were measured by ELISA, using monoclonal antibodies specific for UBC antigen. As a control group, UBC antigen level was also determined in 65 persons who had been referred for urinalysis for other reasons. UBC antigen level more than 1 &#956;g/L which was regarded as positive was found in 49.4% of the patients. In control group, 96.9% had UBC antigen < 1&#956;g/L. Mean UBC antigen level in patients was 3.77 &#956;g/L while it was 0.508 &#956;g/L in controls (P < 0.0001). Sensitivity of UBC antigen was 53.3% and its specificity was 40%. Sensitivity and specificity of urinary cytology was 17.3% and 88.2%, respectively. This difference was statistically significant (P < 0.001). UBC antigen is more sensitive than urinary cytology, although cytology still retains its priority in specificity. It is not yet recommended to replace UBC antigen for cytology due to its low specificity and not favorable sensitivity. |
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| format | Article |
| id | doaj.art-17a560fb42dd4261a5d717651b4b07e0 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 |
| language | English |
| last_indexed | 2024-12-20T01:43:25Z |
| publishDate | 2005-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-17a560fb42dd4261a5d717651b4b07e02022-12-21T19:57:50ZengTehran University of Medical SciencesActa Medica Iranica0044-60252005-06-01433169172SENSITIVITY AND SPECIFICITY OF URINARY BLADDER CANCER ANTIGEN FOR DIAGNOSIS OF BLADDER TUMOR;A COMPARATIVE STUDY WITH URINARY CYTOLOGYK. RadkhahM. R. Nowroozi P. JabalameliCystoscopy and urinary cytology are currently the basis for diagnosis and follow-up of bladder tumors. Research to find a sensitive and specific tumor marker for diagnosis of bladder tumor is actively underway, however, due to low sensitivity and high cost of cytology. This cross-sectional study was performed in 65 patients to evaluate whether urinary bladder cancer (UBC) antigen level can predict the presence of active bladder tumor. In patients with inactive tumor, UBC antigen level was determined in addition to standard cystoscopy and cytology for follow-up. Patients with active tumor were subjected to standard treatment and UBC antigen level determination. UBC antigen levels were measured by ELISA, using monoclonal antibodies specific for UBC antigen. As a control group, UBC antigen level was also determined in 65 persons who had been referred for urinalysis for other reasons. UBC antigen level more than 1 &#956;g/L which was regarded as positive was found in 49.4% of the patients. In control group, 96.9% had UBC antigen < 1&#956;g/L. Mean UBC antigen level in patients was 3.77 &#956;g/L while it was 0.508 &#956;g/L in controls (P < 0.0001). Sensitivity of UBC antigen was 53.3% and its specificity was 40%. Sensitivity and specificity of urinary cytology was 17.3% and 88.2%, respectively. This difference was statistically significant (P < 0.001). UBC antigen is more sensitive than urinary cytology, although cytology still retains its priority in specificity. It is not yet recommended to replace UBC antigen for cytology due to its low specificity and not favorable sensitivity.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/2041.pdf&manuscript_id=2041Urinary bladder cancer antigenurinary cytology |
| spellingShingle | K. Radkhah M. R. Nowroozi P. Jabalameli SENSITIVITY AND SPECIFICITY OF URINARY BLADDER CANCER ANTIGEN FOR DIAGNOSIS OF BLADDER TUMOR;A COMPARATIVE STUDY WITH URINARY CYTOLOGY Acta Medica Iranica Urinary bladder cancer antigen urinary cytology |
| title | SENSITIVITY AND SPECIFICITY OF URINARY BLADDER CANCER ANTIGEN FOR DIAGNOSIS OF BLADDER TUMOR;A COMPARATIVE STUDY WITH URINARY CYTOLOGY |
| title_full | SENSITIVITY AND SPECIFICITY OF URINARY BLADDER CANCER ANTIGEN FOR DIAGNOSIS OF BLADDER TUMOR;A COMPARATIVE STUDY WITH URINARY CYTOLOGY |
| title_fullStr | SENSITIVITY AND SPECIFICITY OF URINARY BLADDER CANCER ANTIGEN FOR DIAGNOSIS OF BLADDER TUMOR;A COMPARATIVE STUDY WITH URINARY CYTOLOGY |
| title_full_unstemmed | SENSITIVITY AND SPECIFICITY OF URINARY BLADDER CANCER ANTIGEN FOR DIAGNOSIS OF BLADDER TUMOR;A COMPARATIVE STUDY WITH URINARY CYTOLOGY |
| title_short | SENSITIVITY AND SPECIFICITY OF URINARY BLADDER CANCER ANTIGEN FOR DIAGNOSIS OF BLADDER TUMOR;A COMPARATIVE STUDY WITH URINARY CYTOLOGY |
| title_sort | sensitivity and specificity of urinary bladder cancer antigen for diagnosis of bladder tumor a comparative study with urinary cytology |
| topic | Urinary bladder cancer antigen urinary cytology |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/2041.pdf&manuscript_id=2041 |
| work_keys_str_mv | AT kradkhah sensitivityandspecificityofurinarybladdercancerantigenfordiagnosisofbladdertumoracomparativestudywithurinarycytology AT mrnowroozipjabalameli sensitivityandspecificityofurinarybladdercancerantigenfordiagnosisofbladdertumoracomparativestudywithurinarycytology |