Diagnostic Values of Dermatoscopy and CD31 Expression in Cutaneous Lymphangioma Circumscriptum

Background: Cutaneous lymphangioma circumscriptum is characterized by clusters of deep-seated, vesicle-like papules. Cutaneous lymphangioma circumscriptum (CLC) is not a tumor but rather a congenital malformation of superficial lymphatics.Objectives: The study aimed to describe the dermoscopic featu...

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Main Authors: Lixia Lu, Siyu Yan, Mingliang Chen, Xiaoyan Huang, Juan Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Medicine
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.738815/full
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author Lixia Lu
Lixia Lu
Lixia Lu
Siyu Yan
Mingliang Chen
Mingliang Chen
Mingliang Chen
Xiaoyan Huang
Juan Su
Juan Su
Juan Su
author_facet Lixia Lu
Lixia Lu
Lixia Lu
Siyu Yan
Mingliang Chen
Mingliang Chen
Mingliang Chen
Xiaoyan Huang
Juan Su
Juan Su
Juan Su
author_sort Lixia Lu
collection DOAJ
description Background: Cutaneous lymphangioma circumscriptum is characterized by clusters of deep-seated, vesicle-like papules. Cutaneous lymphangioma circumscriptum (CLC) is not a tumor but rather a congenital malformation of superficial lymphatics.Objectives: The study aimed to describe the dermoscopic features of CLC and investigate the reason why marked blood components in CLC. Moreover, this study sought to increase awareness of the clinical characteristics of CLC and provide insights into CLC diagnosis.Methods: A representative sample of patients with CLC with demographic information and pathological and dermoscopical results was analyzed. The immunohistochemistry of lymphangioma specimens with CD31 and D2-40 was performed. The clinical manifestations of CLC, demographic information, and the results of immunohistochemistry were statistically analyzed to validate the correlation.Results: Besides the pattern of frog spawn-like blisters, lymphangioma also presented as either transparent or pigmented with dark-red to whitish/yellowish shades. Moreover, lymphangioma manifested as a pattern of dermatofibroma. Furthermore, CD31 was detected in the flattened endothelium and only present in dilated spaces containing enough blood or lymph components.Limitations: This study is limited by its retrospective nature and statistical power.Conclusion: Dermoscopy is useful for the diagnosis of CLC. CD31 positive staining and cystic-dilated spaces showed flattened inner and outer endothelia are the diagnostic features in hypopyon-like shape and blisters resembling frog spawn patterns in CLC. These features can assist in the diagnosis of CLC.
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spelling doaj.art-17a5754882e740368d15c506fa229dcf2022-12-21T18:37:22ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-10-01810.3389/fmed.2021.738815738815Diagnostic Values of Dermatoscopy and CD31 Expression in Cutaneous Lymphangioma CircumscriptumLixia Lu0Lixia Lu1Lixia Lu2Siyu Yan3Mingliang Chen4Mingliang Chen5Mingliang Chen6Xiaoyan Huang7Juan Su8Juan Su9Juan Su10Department of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Skin Cancer and Psoriasis, Central South University, Changsha, ChinaHunan Engineering Research Center of Skin Health and Disease, Central South University, Changsha, ChinaDepartment of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Skin Cancer and Psoriasis, Central South University, Changsha, ChinaHunan Engineering Research Center of Skin Health and Disease, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Skin Cancer and Psoriasis, Central South University, Changsha, ChinaHunan Engineering Research Center of Skin Health and Disease, Central South University, Changsha, ChinaBackground: Cutaneous lymphangioma circumscriptum is characterized by clusters of deep-seated, vesicle-like papules. Cutaneous lymphangioma circumscriptum (CLC) is not a tumor but rather a congenital malformation of superficial lymphatics.Objectives: The study aimed to describe the dermoscopic features of CLC and investigate the reason why marked blood components in CLC. Moreover, this study sought to increase awareness of the clinical characteristics of CLC and provide insights into CLC diagnosis.Methods: A representative sample of patients with CLC with demographic information and pathological and dermoscopical results was analyzed. The immunohistochemistry of lymphangioma specimens with CD31 and D2-40 was performed. The clinical manifestations of CLC, demographic information, and the results of immunohistochemistry were statistically analyzed to validate the correlation.Results: Besides the pattern of frog spawn-like blisters, lymphangioma also presented as either transparent or pigmented with dark-red to whitish/yellowish shades. Moreover, lymphangioma manifested as a pattern of dermatofibroma. Furthermore, CD31 was detected in the flattened endothelium and only present in dilated spaces containing enough blood or lymph components.Limitations: This study is limited by its retrospective nature and statistical power.Conclusion: Dermoscopy is useful for the diagnosis of CLC. CD31 positive staining and cystic-dilated spaces showed flattened inner and outer endothelia are the diagnostic features in hypopyon-like shape and blisters resembling frog spawn patterns in CLC. These features can assist in the diagnosis of CLC.https://www.frontiersin.org/articles/10.3389/fmed.2021.738815/fulldermoscopyimmunohistochemistryCD31dermatoscopecutaneous lymphangioma circumscriptum
spellingShingle Lixia Lu
Lixia Lu
Lixia Lu
Siyu Yan
Mingliang Chen
Mingliang Chen
Mingliang Chen
Xiaoyan Huang
Juan Su
Juan Su
Juan Su
Diagnostic Values of Dermatoscopy and CD31 Expression in Cutaneous Lymphangioma Circumscriptum
Frontiers in Medicine
dermoscopy
immunohistochemistry
CD31
dermatoscope
cutaneous lymphangioma circumscriptum
title Diagnostic Values of Dermatoscopy and CD31 Expression in Cutaneous Lymphangioma Circumscriptum
title_full Diagnostic Values of Dermatoscopy and CD31 Expression in Cutaneous Lymphangioma Circumscriptum
title_fullStr Diagnostic Values of Dermatoscopy and CD31 Expression in Cutaneous Lymphangioma Circumscriptum
title_full_unstemmed Diagnostic Values of Dermatoscopy and CD31 Expression in Cutaneous Lymphangioma Circumscriptum
title_short Diagnostic Values of Dermatoscopy and CD31 Expression in Cutaneous Lymphangioma Circumscriptum
title_sort diagnostic values of dermatoscopy and cd31 expression in cutaneous lymphangioma circumscriptum
topic dermoscopy
immunohistochemistry
CD31
dermatoscope
cutaneous lymphangioma circumscriptum
url https://www.frontiersin.org/articles/10.3389/fmed.2021.738815/full
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