Regulatory T cells contribute to the immunosuppressive phenotype of neutrophils in a mouse model of chronic lymphocytic leukemia

Regulatory T cells contribute to the immunosuppressive phenotype of neutrophils in a mouse model of chronic lymphocytic leukemia

Abstract Background Impaired neutrophil activity is an important issue in chronic lymphocytic leukemia (CLL), as it contributes to a dysfunctional immune response leading to life-threatening infections in patients. Some features typical of CLL neutrophils, e.g., the B-cell-supportive secretion profi...

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Bibliographic Details
Main Authors: Agnieszka Goral, Marta Sledz, Aneta Manda-Handzlik, Adrianna Cieloch, Alicja Wojciechowska, Mieszko Lachota, Agnieszka Mroczek, Urszula Demkow, Radoslaw Zagozdzon, Katarzyna Matusik, Malgorzata Wachowska, Angelika Muchowicz
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Experimental Hematology & Oncology
Subjects:
CD62L
Chronic lymphocytic leukemia (CLL)
Neutrophils
Regulatory T cells (Treg)
Immunosuppression
Online Access:https://doi.org/10.1186/s40164-023-00452-9

Internet

https://doi.org/10.1186/s40164-023-00452-9

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