Innate Lymphoid Cells (ILCs) as Mediators of Inflammation, Release of Cytokines and Lytic Molecules
Innate lymphoid cells (ILCs) are an emerging group of immune cells that provide the first line of defense against various pathogens as well as contributing to tissue repair and inflammation. ILCs have been classically divided into three subgroups based on their cytokine secretion and transcription f...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-12-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/9/12/398 |
| _version_ | 1818040983383703552 |
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| author | Noha Mousaad Elemam Suad Hannawi Azzam A. Maghazachi |
| author_facet | Noha Mousaad Elemam Suad Hannawi Azzam A. Maghazachi |
| author_sort | Noha Mousaad Elemam |
| collection | DOAJ |
| description | Innate lymphoid cells (ILCs) are an emerging group of immune cells that provide the first line of defense against various pathogens as well as contributing to tissue repair and inflammation. ILCs have been classically divided into three subgroups based on their cytokine secretion and transcription factor profiles. ILC nomenclature is analogous to that of T helper cells. Group 1 ILCs composed of natural killer (NK) cells as well as IFN-γ secreting ILC1s. ILC2s have the capability to produce TH2 cytokines while ILC3s and lymphoid tissue inducer (LTis) are subsets of cells that are able to secrete IL-17 and/or IL-22. A recent subset of ILC known as ILC4 was discovered, and the cells of this subset were designated as NK17/NK1 due to their release of IL-17 and IFN-γ. In this review, we sought to explain the subclasses of ILCs and their roles as mediators of lytic enzymes and inflammation. |
| first_indexed | 2024-12-10T08:23:12Z |
| format | Article |
| id | doaj.art-17a88121c2474fe09b83286e5a78586b |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-12-10T08:23:12Z |
| publishDate | 2017-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-17a88121c2474fe09b83286e5a78586b2022-12-22T01:56:18ZengMDPI AGToxins2072-66512017-12-0191239810.3390/toxins9120398toxins9120398Innate Lymphoid Cells (ILCs) as Mediators of Inflammation, Release of Cytokines and Lytic MoleculesNoha Mousaad Elemam0Suad Hannawi1Azzam A. Maghazachi2Department of Clinical Sciences, College of Medicine, and Sharjah Institute for Medical Research (SIMR), University of Sharjah, Sharjah 27272, UAEMedical Department, Ministry of Health and Prevention, Dubai 65522, UAEDepartment of Clinical Sciences, College of Medicine, and Sharjah Institute for Medical Research (SIMR), University of Sharjah, Sharjah 27272, UAEInnate lymphoid cells (ILCs) are an emerging group of immune cells that provide the first line of defense against various pathogens as well as contributing to tissue repair and inflammation. ILCs have been classically divided into three subgroups based on their cytokine secretion and transcription factor profiles. ILC nomenclature is analogous to that of T helper cells. Group 1 ILCs composed of natural killer (NK) cells as well as IFN-γ secreting ILC1s. ILC2s have the capability to produce TH2 cytokines while ILC3s and lymphoid tissue inducer (LTis) are subsets of cells that are able to secrete IL-17 and/or IL-22. A recent subset of ILC known as ILC4 was discovered, and the cells of this subset were designated as NK17/NK1 due to their release of IL-17 and IFN-γ. In this review, we sought to explain the subclasses of ILCs and their roles as mediators of lytic enzymes and inflammation.https://www.mdpi.com/2072-6651/9/12/398NK cellsinnate lymphoid cellslytic moleculesinflammation |
| spellingShingle | Noha Mousaad Elemam Suad Hannawi Azzam A. Maghazachi Innate Lymphoid Cells (ILCs) as Mediators of Inflammation, Release of Cytokines and Lytic Molecules Toxins NK cells innate lymphoid cells lytic molecules inflammation |
| title | Innate Lymphoid Cells (ILCs) as Mediators of Inflammation, Release of Cytokines and Lytic Molecules |
| title_full | Innate Lymphoid Cells (ILCs) as Mediators of Inflammation, Release of Cytokines and Lytic Molecules |
| title_fullStr | Innate Lymphoid Cells (ILCs) as Mediators of Inflammation, Release of Cytokines and Lytic Molecules |
| title_full_unstemmed | Innate Lymphoid Cells (ILCs) as Mediators of Inflammation, Release of Cytokines and Lytic Molecules |
| title_short | Innate Lymphoid Cells (ILCs) as Mediators of Inflammation, Release of Cytokines and Lytic Molecules |
| title_sort | innate lymphoid cells ilcs as mediators of inflammation release of cytokines and lytic molecules |
| topic | NK cells innate lymphoid cells lytic molecules inflammation |
| url | https://www.mdpi.com/2072-6651/9/12/398 |
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