Current strategies for drug delivery to the inner ear
For many years, drug delivery to the inner ear has been a challenge to physicians in the treatment of inner ear disorders. In the past decade, the field of inner ear drug delivery has emerged with the development of new biomaterials and drug delivery technologies to improve the effectiveness of inne...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2013-04-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383513000178 |
| _version_ | 1818193235047088128 |
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| author | Hongzhuo Liu Jinsong Hao Kevin S. Li |
| author_facet | Hongzhuo Liu Jinsong Hao Kevin S. Li |
| author_sort | Hongzhuo Liu |
| collection | DOAJ |
| description | For many years, drug delivery to the inner ear has been a challenge to physicians in the treatment of inner ear disorders. In the past decade, the field of inner ear drug delivery has emerged with the development of new biomaterials and drug delivery technologies to improve the effectiveness of inner ear drug therapy. This paper reviews a number of inner ear drug delivery strategies including systemic, intratympanic, and intracochlear delivery. A focus of this review is the recent advances in intratympanic delivery of medications; approaches utilizing novel biomaterials as well as other recent developments are also discussed. Biotechnology-based approaches, such as gene and stem cell therapy methods are also reviewed. Among the various strategies, local drug delivery approaches including intratympanic and intracochlear drug delivery methods that limit systemic exposure are particularly promising. These inner ear drug delivery systems provide a new opportunity to improve the treatment of inner ear disorders. |
| first_indexed | 2024-12-12T00:43:10Z |
| format | Article |
| id | doaj.art-17ab11047a4c405dae36423cbaae3d12 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 2211-3843 |
| language | English |
| last_indexed | 2024-12-12T00:43:10Z |
| publishDate | 2013-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-17ab11047a4c405dae36423cbaae3d122022-12-22T00:44:12ZengElsevierActa Pharmaceutica Sinica B2211-38352211-38432013-04-0132869610.1016/j.apsb.2013.02.003Current strategies for drug delivery to the inner earHongzhuo Liu0Jinsong Hao1Kevin S. Li2Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati 45267, Ohio, USADivision of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati 45267, Ohio, USADivision of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati 45267, Ohio, USAFor many years, drug delivery to the inner ear has been a challenge to physicians in the treatment of inner ear disorders. In the past decade, the field of inner ear drug delivery has emerged with the development of new biomaterials and drug delivery technologies to improve the effectiveness of inner ear drug therapy. This paper reviews a number of inner ear drug delivery strategies including systemic, intratympanic, and intracochlear delivery. A focus of this review is the recent advances in intratympanic delivery of medications; approaches utilizing novel biomaterials as well as other recent developments are also discussed. Biotechnology-based approaches, such as gene and stem cell therapy methods are also reviewed. Among the various strategies, local drug delivery approaches including intratympanic and intracochlear drug delivery methods that limit systemic exposure are particularly promising. These inner ear drug delivery systems provide a new opportunity to improve the treatment of inner ear disorders.http://www.sciencedirect.com/science/article/pii/S2211383513000178Inner earDrug deliveryIntratympanicIntracochlearGeneStem cell |
| spellingShingle | Hongzhuo Liu Jinsong Hao Kevin S. Li Current strategies for drug delivery to the inner ear Acta Pharmaceutica Sinica B Inner ear Drug delivery Intratympanic Intracochlear Gene Stem cell |
| title | Current strategies for drug delivery to the inner ear |
| title_full | Current strategies for drug delivery to the inner ear |
| title_fullStr | Current strategies for drug delivery to the inner ear |
| title_full_unstemmed | Current strategies for drug delivery to the inner ear |
| title_short | Current strategies for drug delivery to the inner ear |
| title_sort | current strategies for drug delivery to the inner ear |
| topic | Inner ear Drug delivery Intratympanic Intracochlear Gene Stem cell |
| url | http://www.sciencedirect.com/science/article/pii/S2211383513000178 |
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