Current Advances in Technologies for Single Extracellular Vesicle Analysis and Its Clinical Applications in Cancer Diagnosis
Extracellular vesicles (EVs) have been regarded as one of the most potential diagnostic biomarkers for different cancers, due to their unique physiological and pathological functions. However, it is still challenging to precisely analyze the contents and sources of EVs, due to their heterogeneity. H...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/13/1/129 |
| _version_ | 1797445316659642368 |
|---|---|
| author | Lei Qiu Xingzhu Liu Libo Zhu Liqiang Luo Na Sun Renjun Pei |
| author_facet | Lei Qiu Xingzhu Liu Libo Zhu Liqiang Luo Na Sun Renjun Pei |
| author_sort | Lei Qiu |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) have been regarded as one of the most potential diagnostic biomarkers for different cancers, due to their unique physiological and pathological functions. However, it is still challenging to precisely analyze the contents and sources of EVs, due to their heterogeneity. Herein, we summarize the advances in technologies for a single EV analysis, which may provide new strategies to study the heterogeneity of EVs, as well as their cargo, more specifically. Furthermore, the applications of a single EV analysis on cancer early diagnosis are also discussed. |
| first_indexed | 2024-03-09T13:24:01Z |
| format | Article |
| id | doaj.art-17ab921c07cd49eea0d491b969c012e3 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T13:24:01Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-17ab921c07cd49eea0d491b969c012e32023-11-30T21:25:55ZengMDPI AGBiosensors2079-63742023-01-0113112910.3390/bios13010129Current Advances in Technologies for Single Extracellular Vesicle Analysis and Its Clinical Applications in Cancer DiagnosisLei Qiu0Xingzhu Liu1Libo Zhu2Liqiang Luo3Na Sun4Renjun Pei5Department of Chemistry, College of Sciences, Shanghai University, Shanghai 200444, ChinaKey Laboratory for Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, ChinaKey Laboratory for Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, ChinaDepartment of Chemistry, College of Sciences, Shanghai University, Shanghai 200444, ChinaKey Laboratory for Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, ChinaKey Laboratory for Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, ChinaExtracellular vesicles (EVs) have been regarded as one of the most potential diagnostic biomarkers for different cancers, due to their unique physiological and pathological functions. However, it is still challenging to precisely analyze the contents and sources of EVs, due to their heterogeneity. Herein, we summarize the advances in technologies for a single EV analysis, which may provide new strategies to study the heterogeneity of EVs, as well as their cargo, more specifically. Furthermore, the applications of a single EV analysis on cancer early diagnosis are also discussed.https://www.mdpi.com/2079-6374/13/1/129extracellular vesiclesheterogeneitysingle particlecancerdiagnostic applications |
| spellingShingle | Lei Qiu Xingzhu Liu Libo Zhu Liqiang Luo Na Sun Renjun Pei Current Advances in Technologies for Single Extracellular Vesicle Analysis and Its Clinical Applications in Cancer Diagnosis Biosensors extracellular vesicles heterogeneity single particle cancer diagnostic applications |
| title | Current Advances in Technologies for Single Extracellular Vesicle Analysis and Its Clinical Applications in Cancer Diagnosis |
| title_full | Current Advances in Technologies for Single Extracellular Vesicle Analysis and Its Clinical Applications in Cancer Diagnosis |
| title_fullStr | Current Advances in Technologies for Single Extracellular Vesicle Analysis and Its Clinical Applications in Cancer Diagnosis |
| title_full_unstemmed | Current Advances in Technologies for Single Extracellular Vesicle Analysis and Its Clinical Applications in Cancer Diagnosis |
| title_short | Current Advances in Technologies for Single Extracellular Vesicle Analysis and Its Clinical Applications in Cancer Diagnosis |
| title_sort | current advances in technologies for single extracellular vesicle analysis and its clinical applications in cancer diagnosis |
| topic | extracellular vesicles heterogeneity single particle cancer diagnostic applications |
| url | https://www.mdpi.com/2079-6374/13/1/129 |
| work_keys_str_mv | AT leiqiu currentadvancesintechnologiesforsingleextracellularvesicleanalysisanditsclinicalapplicationsincancerdiagnosis AT xingzhuliu currentadvancesintechnologiesforsingleextracellularvesicleanalysisanditsclinicalapplicationsincancerdiagnosis AT libozhu currentadvancesintechnologiesforsingleextracellularvesicleanalysisanditsclinicalapplicationsincancerdiagnosis AT liqiangluo currentadvancesintechnologiesforsingleextracellularvesicleanalysisanditsclinicalapplicationsincancerdiagnosis AT nasun currentadvancesintechnologiesforsingleextracellularvesicleanalysisanditsclinicalapplicationsincancerdiagnosis AT renjunpei currentadvancesintechnologiesforsingleextracellularvesicleanalysisanditsclinicalapplicationsincancerdiagnosis |