Recovery of Focal Brain Ischemia-Induced Behavioral Dysfunction by Intracerebroventricular Injection of Microglia
The function of microglia in the brain parenchyma is not fully understood. Occlusion of the middle cerebral artery (MCA) and reperfusion caused behavioral dysfunction with massive neuronal loss in the rat cerebral cortex and striatum. When exogenous microglia were microinjected into the intracerebro...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2005-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319322807 |
| _version_ | 1811328309328347136 |
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| author | Yoshihisa Kitamura Daijiro Yanagisawa Masatoshi Inden Kazuyuki Takata Daiju Tsuchiya Toshiyuki Kawasaki Takashi Taniguchi Shun Shimohama |
| author_facet | Yoshihisa Kitamura Daijiro Yanagisawa Masatoshi Inden Kazuyuki Takata Daiju Tsuchiya Toshiyuki Kawasaki Takashi Taniguchi Shun Shimohama |
| author_sort | Yoshihisa Kitamura |
| collection | DOAJ |
| description | The function of microglia in the brain parenchyma is not fully understood. Occlusion of the middle cerebral artery (MCA) and reperfusion caused behavioral dysfunction with massive neuronal loss in the rat cerebral cortex and striatum. When exogenous microglia were microinjected into the intracerebroventricle (i.c.v.) during MCA occlusion, focal ischemia-induced behavioral dysfunction was significantly inhibited. At that time, many microglia migrated into the ischemic lesion, and microglia-derived neuron-like cells were barely detectable. These results suggest that exogenous microglia protect against focal ischemia-induced neurodegeneration and improve behavioral dysfunction. Keywords:: behavioral recovery, microglia, focal brain ischemia |
| first_indexed | 2024-04-13T15:24:08Z |
| format | Article |
| id | doaj.art-17acb7e0dc994f9b9fc91d3e7ad571d6 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-04-13T15:24:08Z |
| publishDate | 2005-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-17acb7e0dc994f9b9fc91d3e7ad571d62022-12-22T02:41:34ZengElsevierJournal of Pharmacological Sciences1347-86132005-01-01972289293Recovery of Focal Brain Ischemia-Induced Behavioral Dysfunction by Intracerebroventricular Injection of MicrogliaYoshihisa Kitamura0Daijiro Yanagisawa1Masatoshi Inden2Kazuyuki Takata3Daiju Tsuchiya4Toshiyuki Kawasaki5Takashi Taniguchi6Shun Shimohama7Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan; 21st Century COE Program, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan; Corresponding author. FAX: +81-75-595-4796 E-mail: yo-kita@mb.kyoto-phu.ac.jpDepartment of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607-8412, JapanDepartment of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607-8412, JapanDepartment of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607-8412, JapanDepartment of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607-8412, JapanDepartment of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607-8412, JapanDepartment of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan; 21st Century COE Program, Kyoto Pharmaceutical University, Kyoto 607-8412, JapanDepartment of Neurology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, JapanThe function of microglia in the brain parenchyma is not fully understood. Occlusion of the middle cerebral artery (MCA) and reperfusion caused behavioral dysfunction with massive neuronal loss in the rat cerebral cortex and striatum. When exogenous microglia were microinjected into the intracerebroventricle (i.c.v.) during MCA occlusion, focal ischemia-induced behavioral dysfunction was significantly inhibited. At that time, many microglia migrated into the ischemic lesion, and microglia-derived neuron-like cells were barely detectable. These results suggest that exogenous microglia protect against focal ischemia-induced neurodegeneration and improve behavioral dysfunction. Keywords:: behavioral recovery, microglia, focal brain ischemiahttp://www.sciencedirect.com/science/article/pii/S1347861319322807 |
| spellingShingle | Yoshihisa Kitamura Daijiro Yanagisawa Masatoshi Inden Kazuyuki Takata Daiju Tsuchiya Toshiyuki Kawasaki Takashi Taniguchi Shun Shimohama Recovery of Focal Brain Ischemia-Induced Behavioral Dysfunction by Intracerebroventricular Injection of Microglia Journal of Pharmacological Sciences |
| title | Recovery of Focal Brain Ischemia-Induced Behavioral Dysfunction by Intracerebroventricular Injection of Microglia |
| title_full | Recovery of Focal Brain Ischemia-Induced Behavioral Dysfunction by Intracerebroventricular Injection of Microglia |
| title_fullStr | Recovery of Focal Brain Ischemia-Induced Behavioral Dysfunction by Intracerebroventricular Injection of Microglia |
| title_full_unstemmed | Recovery of Focal Brain Ischemia-Induced Behavioral Dysfunction by Intracerebroventricular Injection of Microglia |
| title_short | Recovery of Focal Brain Ischemia-Induced Behavioral Dysfunction by Intracerebroventricular Injection of Microglia |
| title_sort | recovery of focal brain ischemia induced behavioral dysfunction by intracerebroventricular injection of microglia |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319322807 |
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