Swimming training attenuates oxidative damage and increases enzymatic but not non-enzymatic antioxidant defenses in the rat brain
Although it is well known that physical training ameliorates brain oxidative function after injuries by enhancing the levels of neurotrophic factors and oxidative status, there is little evidence addressing the influence of exercise training itself on brain oxidative damage and data is conflicting....
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Divulgação Científica
2016-09-01
|
| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001000605&tlng=en |
| _version_ | 1819002942885199872 |
|---|---|
| author | L.F. Nonato E. Rocha-Vieira R. Tossige-Gomes A.A. Soares B.A. Soares D.A. Freitas M.X. Oliveira V.A. Mendonça A.C. Lacerda A.R. Massensini H.R. Leite |
| author_facet | L.F. Nonato E. Rocha-Vieira R. Tossige-Gomes A.A. Soares B.A. Soares D.A. Freitas M.X. Oliveira V.A. Mendonça A.C. Lacerda A.R. Massensini H.R. Leite |
| author_sort | L.F. Nonato |
| collection | DOAJ |
| description | Although it is well known that physical training ameliorates brain oxidative function after injuries by enhancing the levels of neurotrophic factors and oxidative status, there is little evidence addressing the influence of exercise training itself on brain oxidative damage and data is conflicting. This study investigated the effect of well-established swimming training protocol on lipid peroxidation and components of antioxidant system in the rat brain. Male Wistar rats were randomized into trained (5 days/week, 8 weeks, 30 min; n=8) and non-trained (n=7) groups. Forty-eight hours after the last session of exercise, animals were euthanized and the brain was collected for oxidative stress analysis. Swimming training decreased thiobarbituric acid reactive substances (TBARS) levels (P<0.05) and increased the activity of the antioxidant enzyme superoxide dismutase (SOD) (P<0.05) with no effect on brain non-enzymatic total antioxidant capacity, estimated by FRAP (ferric-reducing antioxidant power) assay (P>0.05). Moreover, the swimming training promoted metabolic adaptations, such as increased maximal workload capacity (P<0.05) and maintenance of body weight. In this context, the reduced TBARS content and increased SOD antioxidant activity induced by 8 weeks of swimming training are key factors in promoting brain resistance. In conclusion, swimming training attenuated oxidative damage and increased enzymatic antioxidant but not non-enzymatic status in the rat brain. |
| first_indexed | 2024-12-20T23:13:08Z |
| format | Article |
| id | doaj.art-17ae47ff88bd4324a4861d1645f9665a |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-12-20T23:13:08Z |
| publishDate | 2016-09-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-17ae47ff88bd4324a4861d1645f9665a2022-12-21T19:23:41ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2016-09-01491010.1590/1414-431x20165310Swimming training attenuates oxidative damage and increases enzymatic but not non-enzymatic antioxidant defenses in the rat brainL.F. NonatoE. Rocha-VieiraR. Tossige-GomesA.A. SoaresB.A. SoaresD.A. FreitasM.X. OliveiraV.A. MendonçaA.C. LacerdaA.R. MassensiniH.R. LeiteAlthough it is well known that physical training ameliorates brain oxidative function after injuries by enhancing the levels of neurotrophic factors and oxidative status, there is little evidence addressing the influence of exercise training itself on brain oxidative damage and data is conflicting. This study investigated the effect of well-established swimming training protocol on lipid peroxidation and components of antioxidant system in the rat brain. Male Wistar rats were randomized into trained (5 days/week, 8 weeks, 30 min; n=8) and non-trained (n=7) groups. Forty-eight hours after the last session of exercise, animals were euthanized and the brain was collected for oxidative stress analysis. Swimming training decreased thiobarbituric acid reactive substances (TBARS) levels (P<0.05) and increased the activity of the antioxidant enzyme superoxide dismutase (SOD) (P<0.05) with no effect on brain non-enzymatic total antioxidant capacity, estimated by FRAP (ferric-reducing antioxidant power) assay (P>0.05). Moreover, the swimming training promoted metabolic adaptations, such as increased maximal workload capacity (P<0.05) and maintenance of body weight. In this context, the reduced TBARS content and increased SOD antioxidant activity induced by 8 weeks of swimming training are key factors in promoting brain resistance. In conclusion, swimming training attenuated oxidative damage and increased enzymatic antioxidant but not non-enzymatic status in the rat brain.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001000605&tlng=enExercise therapyOxidative stressRatLipid peroxidationSuperoxide dismutaseSwimming training |
| spellingShingle | L.F. Nonato E. Rocha-Vieira R. Tossige-Gomes A.A. Soares B.A. Soares D.A. Freitas M.X. Oliveira V.A. Mendonça A.C. Lacerda A.R. Massensini H.R. Leite Swimming training attenuates oxidative damage and increases enzymatic but not non-enzymatic antioxidant defenses in the rat brain Brazilian Journal of Medical and Biological Research Exercise therapy Oxidative stress Rat Lipid peroxidation Superoxide dismutase Swimming training |
| title | Swimming training attenuates oxidative damage and increases enzymatic but not non-enzymatic antioxidant defenses in the rat brain |
| title_full | Swimming training attenuates oxidative damage and increases enzymatic but not non-enzymatic antioxidant defenses in the rat brain |
| title_fullStr | Swimming training attenuates oxidative damage and increases enzymatic but not non-enzymatic antioxidant defenses in the rat brain |
| title_full_unstemmed | Swimming training attenuates oxidative damage and increases enzymatic but not non-enzymatic antioxidant defenses in the rat brain |
| title_short | Swimming training attenuates oxidative damage and increases enzymatic but not non-enzymatic antioxidant defenses in the rat brain |
| title_sort | swimming training attenuates oxidative damage and increases enzymatic but not non enzymatic antioxidant defenses in the rat brain |
| topic | Exercise therapy Oxidative stress Rat Lipid peroxidation Superoxide dismutase Swimming training |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001000605&tlng=en |
| work_keys_str_mv | AT lfnonato swimmingtrainingattenuatesoxidativedamageandincreasesenzymaticbutnotnonenzymaticantioxidantdefensesintheratbrain AT erochavieira swimmingtrainingattenuatesoxidativedamageandincreasesenzymaticbutnotnonenzymaticantioxidantdefensesintheratbrain AT rtossigegomes swimmingtrainingattenuatesoxidativedamageandincreasesenzymaticbutnotnonenzymaticantioxidantdefensesintheratbrain AT aasoares swimmingtrainingattenuatesoxidativedamageandincreasesenzymaticbutnotnonenzymaticantioxidantdefensesintheratbrain AT basoares swimmingtrainingattenuatesoxidativedamageandincreasesenzymaticbutnotnonenzymaticantioxidantdefensesintheratbrain AT dafreitas swimmingtrainingattenuatesoxidativedamageandincreasesenzymaticbutnotnonenzymaticantioxidantdefensesintheratbrain AT mxoliveira swimmingtrainingattenuatesoxidativedamageandincreasesenzymaticbutnotnonenzymaticantioxidantdefensesintheratbrain AT vamendonca swimmingtrainingattenuatesoxidativedamageandincreasesenzymaticbutnotnonenzymaticantioxidantdefensesintheratbrain AT aclacerda swimmingtrainingattenuatesoxidativedamageandincreasesenzymaticbutnotnonenzymaticantioxidantdefensesintheratbrain AT armassensini swimmingtrainingattenuatesoxidativedamageandincreasesenzymaticbutnotnonenzymaticantioxidantdefensesintheratbrain AT hrleite swimmingtrainingattenuatesoxidativedamageandincreasesenzymaticbutnotnonenzymaticantioxidantdefensesintheratbrain |