Lactobacillus for the treatment and prevention of atopic dermatitis: Clinical and experimental evidence
Atopic dermatitis (AD) is a chronic inflammatory skin disease, accompanied by itching and swelling. The main pathological mechanism of AD is related to the imbalance between Type 2 helper cells (Th2 cells) and Type 1 helper cells (Th1 cells). Currently, no safe and effective means to treat and preve...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1137275/full |
| _version_ | 1797905026068250624 |
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| author | Anni Xie Ailing Chen Yuqing Chen Zichen Luo Shanyu Jiang Daozhen Chen Renqiang Yu Renqiang Yu |
| author_facet | Anni Xie Ailing Chen Yuqing Chen Zichen Luo Shanyu Jiang Daozhen Chen Renqiang Yu Renqiang Yu |
| author_sort | Anni Xie |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is a chronic inflammatory skin disease, accompanied by itching and swelling. The main pathological mechanism of AD is related to the imbalance between Type 2 helper cells (Th2 cells) and Type 1 helper cells (Th1 cells). Currently, no safe and effective means to treat and prevent AD are available; moreover, some treatments have side effects. Probiotics, such as some strains of Lactobacillus, can address these concerns via various pathways: i) facilitating high patient compliance; ii) regulating Th1/Th2 balance, increasing IL-10 secretion, and reducing inflammatory cytokines; iii) accelerating the maturation of the immune system, maintaining intestinal homeostasis, and improving gut microbiota; and iv) improving the symptoms of AD. This review describes the treatment and prevention of AD using 13 species of Lactobacillus. AD is commonly observed in children. Therefore, the review includes a higher proportion of studies on AD in children and fewer in adolescents and adults. However, there are also some strains that do not improve the symptoms of AD and even worsen allergies in children. In addition, a subset of the genus Lactobacillus that can prevent and relieve AD has been identified in vitro. Therefore, future studies should include more in vivo studies and randomized controlled clinical trials. Given the advantages and disadvantages mentioned above, further research in this area is urgently required. |
| first_indexed | 2024-04-10T09:58:31Z |
| format | Article |
| id | doaj.art-17af2044967142c99c73b246e0735539 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-10T09:58:31Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-17af2044967142c99c73b246e07355392023-02-16T10:22:46ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-02-011310.3389/fcimb.2023.11372751137275Lactobacillus for the treatment and prevention of atopic dermatitis: Clinical and experimental evidenceAnni Xie0Ailing Chen1Yuqing Chen2Zichen Luo3Shanyu Jiang4Daozhen Chen5Renqiang Yu6Renqiang Yu7Department of Neonatology, Wuxi Maternity and Child Health Care Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi, ChinaResearch Institute for Reproductive Health and Genetic Diseases, Wuxi Maternity and Child Health Care Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi, ChinaDepartment of Child Health Care, Wuxi Maternity and Child Health Care Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi, ChinaDepartment of Neonatology, Wuxi Maternity and Child Health Care Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi, ChinaDepartment of Neonatology, Wuxi Maternity and Child Health Care Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi, ChinaResearch Institute for Reproductive Health and Genetic Diseases, Wuxi Maternity and Child Health Care Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi, ChinaDepartment of Neonatology, Wuxi Maternity and Child Health Care Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi, ChinaResearch Institute for Reproductive Health and Genetic Diseases, Wuxi Maternity and Child Health Care Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi, ChinaAtopic dermatitis (AD) is a chronic inflammatory skin disease, accompanied by itching and swelling. The main pathological mechanism of AD is related to the imbalance between Type 2 helper cells (Th2 cells) and Type 1 helper cells (Th1 cells). Currently, no safe and effective means to treat and prevent AD are available; moreover, some treatments have side effects. Probiotics, such as some strains of Lactobacillus, can address these concerns via various pathways: i) facilitating high patient compliance; ii) regulating Th1/Th2 balance, increasing IL-10 secretion, and reducing inflammatory cytokines; iii) accelerating the maturation of the immune system, maintaining intestinal homeostasis, and improving gut microbiota; and iv) improving the symptoms of AD. This review describes the treatment and prevention of AD using 13 species of Lactobacillus. AD is commonly observed in children. Therefore, the review includes a higher proportion of studies on AD in children and fewer in adolescents and adults. However, there are also some strains that do not improve the symptoms of AD and even worsen allergies in children. In addition, a subset of the genus Lactobacillus that can prevent and relieve AD has been identified in vitro. Therefore, future studies should include more in vivo studies and randomized controlled clinical trials. Given the advantages and disadvantages mentioned above, further research in this area is urgently required.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1137275/fullatopic dermatitisLactobacillustype 2 helper cellsgut microbiotaimmunomodulation |
| spellingShingle | Anni Xie Ailing Chen Yuqing Chen Zichen Luo Shanyu Jiang Daozhen Chen Renqiang Yu Renqiang Yu Lactobacillus for the treatment and prevention of atopic dermatitis: Clinical and experimental evidence Frontiers in Cellular and Infection Microbiology atopic dermatitis Lactobacillus type 2 helper cells gut microbiota immunomodulation |
| title | Lactobacillus for the treatment and prevention of atopic dermatitis: Clinical and experimental evidence |
| title_full | Lactobacillus for the treatment and prevention of atopic dermatitis: Clinical and experimental evidence |
| title_fullStr | Lactobacillus for the treatment and prevention of atopic dermatitis: Clinical and experimental evidence |
| title_full_unstemmed | Lactobacillus for the treatment and prevention of atopic dermatitis: Clinical and experimental evidence |
| title_short | Lactobacillus for the treatment and prevention of atopic dermatitis: Clinical and experimental evidence |
| title_sort | lactobacillus for the treatment and prevention of atopic dermatitis clinical and experimental evidence |
| topic | atopic dermatitis Lactobacillus type 2 helper cells gut microbiota immunomodulation |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1137275/full |
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