Leader peptide removal in lasso peptide biosynthesis based on penultimate isoleucine residue

Leader peptide removal in lasso peptide biosynthesis based on penultimate isoleucine residue

Lasso peptides are ribosomally synthesized peptides that undergo post-translational modifications including leader peptide removal by B (or the segregated B1 and B2) proteins and core peptide macrolactamization by C proteins to form a unique lariat topology. A conserved threonine residue at the penu...

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Bibliographic Details
Main Authors: Yuwei Duan, Weijing Niu, Linlin Pang, Da-Shuai Mu, Zong-Jun Du, Youming Zhang, Xiaoying Bian, Guannan Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Microbiology
Subjects:
lasso peptide
biosynthesis
post-translational modification
phosphorylation
peptidase
penultimate isoleucine residue
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1181125/full

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