Influence of p53 (rs1625895) polymorphism in kidney transplant recipients
Reperfusion injury predisposes the kidney allograft to acute rejection. Apoptosis is a mechanism that results in graft injury, and TP53 is an important involved gene. To determine the association between single nucleotide polymorphism (SNP) in the pro-apoptotic protein p53 (rs1625895) and acute reje...
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Format: | Article |
Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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Series: | Saudi Journal of Kidney Diseases and Transplantation |
Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2014;volume=25;issue=6;spage=1160;epage=1165;aulast=Azarpira |
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author | Negar Azarpira Koorosh Kazemi Masumeh Darai |
author_facet | Negar Azarpira Koorosh Kazemi Masumeh Darai |
author_sort | Negar Azarpira |
collection | DOAJ |
description | Reperfusion injury predisposes the kidney allograft to acute rejection. Apoptosis is a mechanism that results in graft injury, and TP53 is an important involved gene. To determine the association between single nucleotide polymorphism (SNP) in the pro-apoptotic protein p53 (rs1625895) and acute rejection in renal transplants, we studied 100 recipients of kidney allografts and 100 healthy individuals served as controls. The polymorphism was determined by the polymerase chain reaction restriction-fragment length polymorphism (PCR-RFLP) test. Overall, 31 recipients developed rejection. There was no difference in the genotype frequencies between the recipients and the controls. However, we found a difference of genotype and allele frequencies between recipients with and those without rejection. The WW genotype was more frequent in recipients with rejection. Although rejection is a complex immunologic event and functional importance of SNPs has not been confirmed yet, we suggest that wild type p53 may promote apoptosis during inflammation. |
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format | Article |
id | doaj.art-17b12f6863db4e14ad336792bea19a54 |
institution | Directory Open Access Journal |
issn | 1319-2442 |
language | English |
last_indexed | 2024-12-12T15:10:52Z |
publishDate | 2014-01-01 |
publisher | Wolters Kluwer Medknow Publications |
record_format | Article |
series | Saudi Journal of Kidney Diseases and Transplantation |
spelling | doaj.art-17b12f6863db4e14ad336792bea19a542022-12-22T00:20:37ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422014-01-012561160116510.4103/1319-2442.144248Influence of p53 (rs1625895) polymorphism in kidney transplant recipientsNegar AzarpiraKoorosh KazemiMasumeh DaraiReperfusion injury predisposes the kidney allograft to acute rejection. Apoptosis is a mechanism that results in graft injury, and TP53 is an important involved gene. To determine the association between single nucleotide polymorphism (SNP) in the pro-apoptotic protein p53 (rs1625895) and acute rejection in renal transplants, we studied 100 recipients of kidney allografts and 100 healthy individuals served as controls. The polymorphism was determined by the polymerase chain reaction restriction-fragment length polymorphism (PCR-RFLP) test. Overall, 31 recipients developed rejection. There was no difference in the genotype frequencies between the recipients and the controls. However, we found a difference of genotype and allele frequencies between recipients with and those without rejection. The WW genotype was more frequent in recipients with rejection. Although rejection is a complex immunologic event and functional importance of SNPs has not been confirmed yet, we suggest that wild type p53 may promote apoptosis during inflammation.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2014;volume=25;issue=6;spage=1160;epage=1165;aulast=Azarpira |
spellingShingle | Negar Azarpira Koorosh Kazemi Masumeh Darai Influence of p53 (rs1625895) polymorphism in kidney transplant recipients Saudi Journal of Kidney Diseases and Transplantation |
title | Influence of p53 (rs1625895) polymorphism in kidney transplant recipients |
title_full | Influence of p53 (rs1625895) polymorphism in kidney transplant recipients |
title_fullStr | Influence of p53 (rs1625895) polymorphism in kidney transplant recipients |
title_full_unstemmed | Influence of p53 (rs1625895) polymorphism in kidney transplant recipients |
title_short | Influence of p53 (rs1625895) polymorphism in kidney transplant recipients |
title_sort | influence of p53 rs1625895 polymorphism in kidney transplant recipients |
url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2014;volume=25;issue=6;spage=1160;epage=1165;aulast=Azarpira |
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