Influence of p53 (rs1625895) polymorphism in kidney transplant recipients

Reperfusion injury predisposes the kidney allograft to acute rejection. Apoptosis is a mechanism that results in graft injury, and TP53 is an important involved gene. To determine the association between single nucleotide polymorphism (SNP) in the pro-apoptotic protein p53 (rs1625895) and acute reje...

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Main Authors: Negar Azarpira, Koorosh Kazemi, Masumeh Darai
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-01-01
Series:Saudi Journal of Kidney Diseases and Transplantation
Online Access:http://www.sjkdt.org/article.asp?issn=1319-2442;year=2014;volume=25;issue=6;spage=1160;epage=1165;aulast=Azarpira
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author Negar Azarpira
Koorosh Kazemi
Masumeh Darai
author_facet Negar Azarpira
Koorosh Kazemi
Masumeh Darai
author_sort Negar Azarpira
collection DOAJ
description Reperfusion injury predisposes the kidney allograft to acute rejection. Apoptosis is a mechanism that results in graft injury, and TP53 is an important involved gene. To determine the association between single nucleotide polymorphism (SNP) in the pro-apoptotic protein p53 (rs1625895) and acute rejection in renal transplants, we studied 100 recipients of kidney allografts and 100 healthy individuals served as controls. The polymorphism was determined by the polymerase chain reaction restriction-fragment length polymorphism (PCR-RFLP) test. Overall, 31 recipients developed rejection. There was no difference in the genotype frequencies between the recipients and the controls. However, we found a difference of genotype and allele frequencies between recipients with and those without rejection. The WW genotype was more frequent in recipients with rejection. Although rejection is a complex immunologic event and functional importance of SNPs has not been confirmed yet, we suggest that wild type p53 may promote apoptosis during inflammation.
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spelling doaj.art-17b12f6863db4e14ad336792bea19a542022-12-22T00:20:37ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422014-01-012561160116510.4103/1319-2442.144248Influence of p53 (rs1625895) polymorphism in kidney transplant recipientsNegar AzarpiraKoorosh KazemiMasumeh DaraiReperfusion injury predisposes the kidney allograft to acute rejection. Apoptosis is a mechanism that results in graft injury, and TP53 is an important involved gene. To determine the association between single nucleotide polymorphism (SNP) in the pro-apoptotic protein p53 (rs1625895) and acute rejection in renal transplants, we studied 100 recipients of kidney allografts and 100 healthy individuals served as controls. The polymorphism was determined by the polymerase chain reaction restriction-fragment length polymorphism (PCR-RFLP) test. Overall, 31 recipients developed rejection. There was no difference in the genotype frequencies between the recipients and the controls. However, we found a difference of genotype and allele frequencies between recipients with and those without rejection. The WW genotype was more frequent in recipients with rejection. Although rejection is a complex immunologic event and functional importance of SNPs has not been confirmed yet, we suggest that wild type p53 may promote apoptosis during inflammation.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2014;volume=25;issue=6;spage=1160;epage=1165;aulast=Azarpira
spellingShingle Negar Azarpira
Koorosh Kazemi
Masumeh Darai
Influence of p53 (rs1625895) polymorphism in kidney transplant recipients
Saudi Journal of Kidney Diseases and Transplantation
title Influence of p53 (rs1625895) polymorphism in kidney transplant recipients
title_full Influence of p53 (rs1625895) polymorphism in kidney transplant recipients
title_fullStr Influence of p53 (rs1625895) polymorphism in kidney transplant recipients
title_full_unstemmed Influence of p53 (rs1625895) polymorphism in kidney transplant recipients
title_short Influence of p53 (rs1625895) polymorphism in kidney transplant recipients
title_sort influence of p53 rs1625895 polymorphism in kidney transplant recipients
url http://www.sjkdt.org/article.asp?issn=1319-2442;year=2014;volume=25;issue=6;spage=1160;epage=1165;aulast=Azarpira
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AT masumehdarai influenceofp53rs1625895polymorphisminkidneytransplantrecipients