2-(Substituted phenyl)-3,4-dihydroisoquinolin-2-iums as Novel Antifungal Lead Compounds: Biological Evaluation and Structure-Activity Relationships

2-(Substituted phenyl)-3,4-dihydroisoquinolin-2-iums as Novel Antifungal Lead Compounds: Biological Evaluation and Structure-Activity Relationships

The title compounds are a class of structurally simple analogues of quaternary benzo[c]phenanthridine alkaloids (QBAs). In order to develop novel QBA-like antifungal drugs, in this study, 24 of the title compounds with various substituents on the N-phenyl ring were evaluated for bioactivity against...

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Bibliographic Details
Main Authors: Xin-Juan Yang, Fang Miao, Li-Fei Zhu, Cen Zhang, Rui Yang, Zhe Hou, Le Zhou
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Molecules
Subjects:
2-aryl-3,4-dihydroisoquinolin-2-ium
antifungal activity
phytopathogenic fungi
structure-activity relationship
sanguinarine
chelerythrine
Online Access:http://www.mdpi.com/1420-3049/18/9/10413

Internet

http://www.mdpi.com/1420-3049/18/9/10413

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