NK Cells Under Hypoxia: The Two Faces of Vascularization in Tumor and Pregnancy
Environmental conditions greatly shape the phenotype and function of immune cells. Specifically, hypoxic conditions that exist within tissues and organs have been reported to affect both the adaptive and the innate immune system. Natural killer (NK) cells belong to the innate immune system. They are...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.924775/full |
| _version_ | 1818211634847416320 |
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| author | Irene Garcés-Lázaro Rebecca Kotzur Adelheid Cerwenka Adelheid Cerwenka Ofer Mandelboim |
| author_facet | Irene Garcés-Lázaro Rebecca Kotzur Adelheid Cerwenka Adelheid Cerwenka Ofer Mandelboim |
| author_sort | Irene Garcés-Lázaro |
| collection | DOAJ |
| description | Environmental conditions greatly shape the phenotype and function of immune cells. Specifically, hypoxic conditions that exist within tissues and organs have been reported to affect both the adaptive and the innate immune system. Natural killer (NK) cells belong to the innate immune system. They are among the first immune cells responding to infections and are involved in tumor surveillance. NK cells produce cytokines that shape other innate and adaptive immune cells, and they produce cytolytic molecules leading to target cell killing. Therefore, they are not only involved in steady state tissue homeostasis, but also in pathogen and tumor clearance. Hence, understanding the role of NK cells in pathological and physiological immune biology is an emerging field. To date, it remains incompletely understood how the tissue microenvironment shapes NK cell phenotype and function. In particular, the impact of low oxygen concentrations in tissues on NK cell reactivity has not been systematically dissected. Here, we present a comprehensive review focusing on two highly compelling hypoxic tissue environments, the tumor microenvironment (pathological) and the decidua (physiological) and compare their impact on NK cell reactivity. |
| first_indexed | 2024-12-12T05:35:37Z |
| format | Article |
| id | doaj.art-17b25b1fd1f442a18719386b304092e0 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T05:35:37Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-17b25b1fd1f442a18719386b304092e02022-12-22T00:36:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-06-011310.3389/fimmu.2022.924775924775NK Cells Under Hypoxia: The Two Faces of Vascularization in Tumor and PregnancyIrene Garcés-Lázaro0Rebecca Kotzur1Adelheid Cerwenka2Adelheid Cerwenka3Ofer Mandelboim4Department of Immunobiochemistry, Mannheim Institute of Innate Immunosciences (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyThe Lautenberg Center for General and Tumor Immunology, Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, IsraelDepartment of Immunobiochemistry, Mannheim Institute of Innate Immunosciences (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyEuropean Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyThe Lautenberg Center for General and Tumor Immunology, Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, IsraelEnvironmental conditions greatly shape the phenotype and function of immune cells. Specifically, hypoxic conditions that exist within tissues and organs have been reported to affect both the adaptive and the innate immune system. Natural killer (NK) cells belong to the innate immune system. They are among the first immune cells responding to infections and are involved in tumor surveillance. NK cells produce cytokines that shape other innate and adaptive immune cells, and they produce cytolytic molecules leading to target cell killing. Therefore, they are not only involved in steady state tissue homeostasis, but also in pathogen and tumor clearance. Hence, understanding the role of NK cells in pathological and physiological immune biology is an emerging field. To date, it remains incompletely understood how the tissue microenvironment shapes NK cell phenotype and function. In particular, the impact of low oxygen concentrations in tissues on NK cell reactivity has not been systematically dissected. Here, we present a comprehensive review focusing on two highly compelling hypoxic tissue environments, the tumor microenvironment (pathological) and the decidua (physiological) and compare their impact on NK cell reactivity.https://www.frontiersin.org/articles/10.3389/fimmu.2022.924775/fullhypoxiaNK cellsvascularizationtumor microenvironmentpregnancy |
| spellingShingle | Irene Garcés-Lázaro Rebecca Kotzur Adelheid Cerwenka Adelheid Cerwenka Ofer Mandelboim NK Cells Under Hypoxia: The Two Faces of Vascularization in Tumor and Pregnancy Frontiers in Immunology hypoxia NK cells vascularization tumor microenvironment pregnancy |
| title | NK Cells Under Hypoxia: The Two Faces of Vascularization in Tumor and Pregnancy |
| title_full | NK Cells Under Hypoxia: The Two Faces of Vascularization in Tumor and Pregnancy |
| title_fullStr | NK Cells Under Hypoxia: The Two Faces of Vascularization in Tumor and Pregnancy |
| title_full_unstemmed | NK Cells Under Hypoxia: The Two Faces of Vascularization in Tumor and Pregnancy |
| title_short | NK Cells Under Hypoxia: The Two Faces of Vascularization in Tumor and Pregnancy |
| title_sort | nk cells under hypoxia the two faces of vascularization in tumor and pregnancy |
| topic | hypoxia NK cells vascularization tumor microenvironment pregnancy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.924775/full |
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