Plugging Small RNAs into the Network
ABSTRACT Small RNAs (sRNAs) have been discovered in every bacterium examined and have been shown to play important roles in the regulation of a diverse range of behaviors, from metabolism to infection. However, despite a wide range of available techniques for discovering and validating sRNA regulato...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2020-06-01
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| Series: | mSystems |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/mSystems.00422-20 |
| _version_ | 1831583940041768960 |
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| author | Lars Barquist |
| author_facet | Lars Barquist |
| author_sort | Lars Barquist |
| collection | DOAJ |
| description | ABSTRACT Small RNAs (sRNAs) have been discovered in every bacterium examined and have been shown to play important roles in the regulation of a diverse range of behaviors, from metabolism to infection. However, despite a wide range of available techniques for discovering and validating sRNA regulatory interactions, only a minority of these molecules have been well characterized. In part, this is due to the nature of posttranscriptional regulation: the activity of an sRNA depends on the state of the transcriptome as a whole, so characterization is best carried out under the conditions in which it is naturally active. In this issue of mSystems, Arrieta-Ortiz and colleagues (M. L. Arrieta-Ortiz, C. Hafemeister, B. Shuster, N. S. Baliga, et al., mSystems 5:e00057-20, 2020, https://doi.org/10.1128/mSystems.00057-20) present a network inference approach based on estimating sRNA activity across transcriptomic compendia. This shows promise not only for identifying new sRNA regulatory interactions but also for pinpointing the conditions in which these interactions occur, providing a new avenue toward functional characterization of sRNAs. |
| first_indexed | 2024-12-17T20:50:59Z |
| format | Article |
| id | doaj.art-17b7b2dbb6a64b00946cc8a93128789b |
| institution | Directory Open Access Journal |
| issn | 2379-5077 |
| language | English |
| last_indexed | 2024-12-17T20:50:59Z |
| publishDate | 2020-06-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mSystems |
| spelling | doaj.art-17b7b2dbb6a64b00946cc8a93128789b2022-12-21T21:33:01ZengAmerican Society for MicrobiologymSystems2379-50772020-06-015310.1128/mSystems.00422-20Plugging Small RNAs into the NetworkLars Barquist0Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, GermanyABSTRACT Small RNAs (sRNAs) have been discovered in every bacterium examined and have been shown to play important roles in the regulation of a diverse range of behaviors, from metabolism to infection. However, despite a wide range of available techniques for discovering and validating sRNA regulatory interactions, only a minority of these molecules have been well characterized. In part, this is due to the nature of posttranscriptional regulation: the activity of an sRNA depends on the state of the transcriptome as a whole, so characterization is best carried out under the conditions in which it is naturally active. In this issue of mSystems, Arrieta-Ortiz and colleagues (M. L. Arrieta-Ortiz, C. Hafemeister, B. Shuster, N. S. Baliga, et al., mSystems 5:e00057-20, 2020, https://doi.org/10.1128/mSystems.00057-20) present a network inference approach based on estimating sRNA activity across transcriptomic compendia. This shows promise not only for identifying new sRNA regulatory interactions but also for pinpointing the conditions in which these interactions occur, providing a new avenue toward functional characterization of sRNAs.https://journals.asm.org/doi/10.1128/mSystems.00422-20network inferencencRNAsRNA |
| spellingShingle | Lars Barquist Plugging Small RNAs into the Network mSystems network inference ncRNA sRNA |
| title | Plugging Small RNAs into the Network |
| title_full | Plugging Small RNAs into the Network |
| title_fullStr | Plugging Small RNAs into the Network |
| title_full_unstemmed | Plugging Small RNAs into the Network |
| title_short | Plugging Small RNAs into the Network |
| title_sort | plugging small rnas into the network |
| topic | network inference ncRNA sRNA |
| url | https://journals.asm.org/doi/10.1128/mSystems.00422-20 |
| work_keys_str_mv | AT larsbarquist pluggingsmallrnasintothenetwork |