GCN5L1 regulates pulmonary surfactant production by modulating lamellar body biogenesis and trafficking in mouse alveolar epithelial cells

GCN5L1 regulates pulmonary surfactant production by modulating lamellar body biogenesis and trafficking in mouse alveolar epithelial cells

Abstract Background The pulmonary surfactant that lines the air–liquid surface within alveoli is a protein–lipid mixture essential for gas exchange. Surfactant lipids and proteins are synthesized and stored in the lamellar body (LB) before being secreted from alveolar type II (AT2) cells. The molecu...

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Bibliographic Details
Main Authors: Wenqin Xu, Xiaocui Ma, Qing Wang, Jingjing Ye, Nengqian Wang, Zhenzhen Ye, Tianbing Chen
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Cellular & Molecular Biology Letters
Subjects:
Pulmonary surfactant
Type II alveolar epithelial cell
Lamellar body
Trafficking
GCN5L1
Online Access:https://doi.org/10.1186/s11658-023-00506-0

Internet

https://doi.org/10.1186/s11658-023-00506-0

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