Paper-Based Fluidic Sensing Platforms for β-Adrenergic Agonist Residue Point-of-Care Testing
The illegal use of β-adrenergic agonists during livestock growth poses a threat to public health; the long-term intake of this medication can cause serious physiological side effects and even death. Therefore, rapid detection methods for β-adrenergic agonist residues on-site are required. Traditiona...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/12/7/518 |
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| author | Hongzhi Luo Shan Liu Lina Shi Zhu Li Qianwen Bai Xiaoxin Du Lijun Wang He Zha Chenzhong Li |
| author_facet | Hongzhi Luo Shan Liu Lina Shi Zhu Li Qianwen Bai Xiaoxin Du Lijun Wang He Zha Chenzhong Li |
| author_sort | Hongzhi Luo |
| collection | DOAJ |
| description | The illegal use of β-adrenergic agonists during livestock growth poses a threat to public health; the long-term intake of this medication can cause serious physiological side effects and even death. Therefore, rapid detection methods for β-adrenergic agonist residues on-site are required. Traditional detection methods such as liquid chromatography have limitations in terms of expensive instruments and complex operations. In contrast, paper methods are low cost, ubiquitous, and portable, which has led to them becoming the preferred detection method in recent years. Various paper-based fluidic devices have been developed to detect β-adrenergic agonist residues, including lateral flow immunoassays (LFAs) and microfluidic paper-based analytical devices (μPADs). In this review, the application of LFAs for the detection of β-agonists is summarized comprehensively, focusing on the latest advances in novel labeling and detection strategies. The use of μPADs as an analytical platform has attracted interest over the past decade due to their unique advantages and application for detecting β-adrenergic agonists, which are introduced here. Vertical flow immunoassays are also discussed for their shorter assay time and stronger multiplexing capabilities compared with LFAs. Furthermore, the development direction and prospects for the commercialization of paper-based devices are considered, shedding light on the development of point-of-care testing devices for β-adrenergic agonist residue detection. |
| first_indexed | 2024-03-09T10:21:57Z |
| format | Article |
| id | doaj.art-17b9e54b56dc404b8e09b6a39988ee98 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T10:21:57Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-17b9e54b56dc404b8e09b6a39988ee982023-12-01T21:57:07ZengMDPI AGBiosensors2079-63742022-07-0112751810.3390/bios12070518Paper-Based Fluidic Sensing Platforms for β-Adrenergic Agonist Residue Point-of-Care TestingHongzhi Luo0Shan Liu1Lina Shi2Zhu Li3Qianwen Bai4Xiaoxin Du5Lijun Wang6He Zha7Chenzhong Li8Department of Laboratory Medicine, The Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi 563002, ChinaSichuan Provincial Key Laboratory for Human Disease Gene Study, Department of Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, University of Electronic Science and Technology, Chengdu 610072, ChinaSchool of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, ChinaCollege of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, ChinaSichuan Jinxin Women & Children Hospital, Chengdu 610066, ChinaOffice of Scientific Research & Development, University of Electronic Science and Technology, Chengdu 610054, ChinaDepartment of Ophthalmology, The Third People’s Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, ChinaDepartment of Laboratory Medicine, The Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi 563002, ChinaDepartment of Biochemistry and Molecular Biology, School of Medicine, Tulane University, New Orleans, LA 70112, USAThe illegal use of β-adrenergic agonists during livestock growth poses a threat to public health; the long-term intake of this medication can cause serious physiological side effects and even death. Therefore, rapid detection methods for β-adrenergic agonist residues on-site are required. Traditional detection methods such as liquid chromatography have limitations in terms of expensive instruments and complex operations. In contrast, paper methods are low cost, ubiquitous, and portable, which has led to them becoming the preferred detection method in recent years. Various paper-based fluidic devices have been developed to detect β-adrenergic agonist residues, including lateral flow immunoassays (LFAs) and microfluidic paper-based analytical devices (μPADs). In this review, the application of LFAs for the detection of β-agonists is summarized comprehensively, focusing on the latest advances in novel labeling and detection strategies. The use of μPADs as an analytical platform has attracted interest over the past decade due to their unique advantages and application for detecting β-adrenergic agonists, which are introduced here. Vertical flow immunoassays are also discussed for their shorter assay time and stronger multiplexing capabilities compared with LFAs. Furthermore, the development direction and prospects for the commercialization of paper-based devices are considered, shedding light on the development of point-of-care testing devices for β-adrenergic agonist residue detection.https://www.mdpi.com/2079-6374/12/7/518β-adrenergic agonistspaper-based devicelateral flow immunoassaypoint-of-care testingbiosensorsmicrofluidics |
| spellingShingle | Hongzhi Luo Shan Liu Lina Shi Zhu Li Qianwen Bai Xiaoxin Du Lijun Wang He Zha Chenzhong Li Paper-Based Fluidic Sensing Platforms for β-Adrenergic Agonist Residue Point-of-Care Testing Biosensors β-adrenergic agonists paper-based device lateral flow immunoassay point-of-care testing biosensors microfluidics |
| title | Paper-Based Fluidic Sensing Platforms for β-Adrenergic Agonist Residue Point-of-Care Testing |
| title_full | Paper-Based Fluidic Sensing Platforms for β-Adrenergic Agonist Residue Point-of-Care Testing |
| title_fullStr | Paper-Based Fluidic Sensing Platforms for β-Adrenergic Agonist Residue Point-of-Care Testing |
| title_full_unstemmed | Paper-Based Fluidic Sensing Platforms for β-Adrenergic Agonist Residue Point-of-Care Testing |
| title_short | Paper-Based Fluidic Sensing Platforms for β-Adrenergic Agonist Residue Point-of-Care Testing |
| title_sort | paper based fluidic sensing platforms for β adrenergic agonist residue point of care testing |
| topic | β-adrenergic agonists paper-based device lateral flow immunoassay point-of-care testing biosensors microfluidics |
| url | https://www.mdpi.com/2079-6374/12/7/518 |
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