Exploring pharmacokinetics of talazoparib in ABCB1/ABCG2-deficient mice using a novel UHPLC-MS/MS method

Exploring pharmacokinetics of talazoparib in ABCB1/ABCG2-deficient mice using a novel UHPLC-MS/MS method

A rapid, sensitive, and simple UHPLC-MS/MS method for the determination of the PARP inhibitor talazoparib in mouse plasma was developed and validated using [13C,2H4]-talazoparib as an internal standard (IS). The assay procedure involved extraction of talazoparib and the IS from plasma using a single...

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Bibliographic Details
Main Authors: Zahra Talebi, Dominique A. Garrison, Eric D. Eisenmann, Kalindi Parmar, Geoffrey I. Shapiro, Michelle A. Rudek, Alex Sparreboom, Yan Jin
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Heliyon
Subjects:
ABC transporters
Mouse plasma
Pharmacokinetics
Talazoparib
UHPLC-MS/MS
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402308180X

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http://www.sciencedirect.com/science/article/pii/S240584402308180X

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