Metabolic Reprogramming in Cancer: Role of HPV 16 Variants
Metabolic reprogramming is considered one of the hallmarks in cancer and is characterized by increased glycolysis and lactate production, even in the presence of oxygen, which leads the cancer cells to a process called “aerobic glycolysis” or “Warburg effect”. The E6 and E7 oncoproteins of human pap...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/3/347 |
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| author | Adán Arizmendi-Izazaga Napoleón Navarro-Tito Hilda Jiménez-Wences Miguel A. Mendoza-Catalán Dinorah N. Martínez-Carrillo Ana E. Zacapala-Gómez Monserrat Olea-Flores Roberto Dircio-Maldonado Francisco I. Torres-Rojas Diana G. Soto-Flores Berenice Illades-Aguiar Julio Ortiz-Ortiz |
| author_facet | Adán Arizmendi-Izazaga Napoleón Navarro-Tito Hilda Jiménez-Wences Miguel A. Mendoza-Catalán Dinorah N. Martínez-Carrillo Ana E. Zacapala-Gómez Monserrat Olea-Flores Roberto Dircio-Maldonado Francisco I. Torres-Rojas Diana G. Soto-Flores Berenice Illades-Aguiar Julio Ortiz-Ortiz |
| author_sort | Adán Arizmendi-Izazaga |
| collection | DOAJ |
| description | Metabolic reprogramming is considered one of the hallmarks in cancer and is characterized by increased glycolysis and lactate production, even in the presence of oxygen, which leads the cancer cells to a process called “aerobic glycolysis” or “Warburg effect”. The E6 and E7 oncoproteins of human papillomavirus 16 (HPV 16) favor the Warburg effect through their interaction with a molecule that regulates cellular metabolism, such as p53, retinoblastoma protein (pRb), c-Myc, and hypoxia inducible factor 1α (HIF-1α). Besides, the impact of the E6 and E7 variants of HPV 16 on metabolic reprogramming through proteins such as HIF-1α may be related to their oncogenicity by favoring cellular metabolism modifications to satisfy the energy demands necessary for viral persistence and cancer development. This review will discuss the role of HPV 16 E6 and E7 variants in metabolic reprogramming and their contribution to developing and preserving the malignant phenotype of cancers associated with HPV 16 infection. |
| first_indexed | 2024-03-10T13:12:16Z |
| format | Article |
| id | doaj.art-17bc1868cf2a4472b66fa52322041db1 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T13:12:16Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-17bc1868cf2a4472b66fa52322041db12023-11-21T10:39:23ZengMDPI AGPathogens2076-08172021-03-0110334710.3390/pathogens10030347Metabolic Reprogramming in Cancer: Role of HPV 16 VariantsAdán Arizmendi-Izazaga0Napoleón Navarro-Tito1Hilda Jiménez-Wences2Miguel A. Mendoza-Catalán3Dinorah N. Martínez-Carrillo4Ana E. Zacapala-Gómez5Monserrat Olea-Flores6Roberto Dircio-Maldonado7Francisco I. Torres-Rojas8Diana G. Soto-Flores9Berenice Illades-Aguiar10Julio Ortiz-Ortiz11Laboratorio de Biomedicina Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas S/N, Ciudad Universitaria, Colonia La Haciendita, Chilpancingo C.P. 39090, Guerrero, MexicoLaboratorio de Biología Celular del Cáncer, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas S/N, Ciudad Universitaria, Colonia La Haciendita, Chilpancingo C.P. 39090, Guerrero, MexicoLaboratorio de Investigación en Biomoléculas, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas S/N, Ciudad Universitaria, Colonia La Haciendita, Chilpancingo C.P. 39090, Guerrero, MexicoLaboratorio de Biomedicina Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas S/N, Ciudad Universitaria, Colonia La Haciendita, Chilpancingo C.P. 39090, Guerrero, MexicoLaboratorio de Investigación en Biomoléculas, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas S/N, Ciudad Universitaria, Colonia La Haciendita, Chilpancingo C.P. 39090, Guerrero, MexicoLaboratorio de Biomedicina Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas S/N, Ciudad Universitaria, Colonia La Haciendita, Chilpancingo C.P. 39090, Guerrero, MexicoLaboratorio de Biología Celular del Cáncer, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas S/N, Ciudad Universitaria, Colonia La Haciendita, Chilpancingo C.P. 39090, Guerrero, MexicoLaboratorio de Investigación Clínica, Facultad de Ciencias, Químico Biológicas, Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas S/N, Ciudad Universitaria, Colonia La Haciendita, Chilpancingo C.P. 39090, Guerrero, MexicoLaboratorio de Biomedicina Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas S/N, Ciudad Universitaria, Colonia La Haciendita, Chilpancingo C.P. 39090, Guerrero, MexicoLaboratorio de Biomedicina Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas S/N, Ciudad Universitaria, Colonia La Haciendita, Chilpancingo C.P. 39090, Guerrero, MexicoLaboratorio de Biomedicina Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas S/N, Ciudad Universitaria, Colonia La Haciendita, Chilpancingo C.P. 39090, Guerrero, MexicoLaboratorio de Biomedicina Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas S/N, Ciudad Universitaria, Colonia La Haciendita, Chilpancingo C.P. 39090, Guerrero, MexicoMetabolic reprogramming is considered one of the hallmarks in cancer and is characterized by increased glycolysis and lactate production, even in the presence of oxygen, which leads the cancer cells to a process called “aerobic glycolysis” or “Warburg effect”. The E6 and E7 oncoproteins of human papillomavirus 16 (HPV 16) favor the Warburg effect through their interaction with a molecule that regulates cellular metabolism, such as p53, retinoblastoma protein (pRb), c-Myc, and hypoxia inducible factor 1α (HIF-1α). Besides, the impact of the E6 and E7 variants of HPV 16 on metabolic reprogramming through proteins such as HIF-1α may be related to their oncogenicity by favoring cellular metabolism modifications to satisfy the energy demands necessary for viral persistence and cancer development. This review will discuss the role of HPV 16 E6 and E7 variants in metabolic reprogramming and their contribution to developing and preserving the malignant phenotype of cancers associated with HPV 16 infection.https://www.mdpi.com/2076-0817/10/3/347HPV 16 variantsmetabolic reprogrammingcancer |
| spellingShingle | Adán Arizmendi-Izazaga Napoleón Navarro-Tito Hilda Jiménez-Wences Miguel A. Mendoza-Catalán Dinorah N. Martínez-Carrillo Ana E. Zacapala-Gómez Monserrat Olea-Flores Roberto Dircio-Maldonado Francisco I. Torres-Rojas Diana G. Soto-Flores Berenice Illades-Aguiar Julio Ortiz-Ortiz Metabolic Reprogramming in Cancer: Role of HPV 16 Variants Pathogens HPV 16 variants metabolic reprogramming cancer |
| title | Metabolic Reprogramming in Cancer: Role of HPV 16 Variants |
| title_full | Metabolic Reprogramming in Cancer: Role of HPV 16 Variants |
| title_fullStr | Metabolic Reprogramming in Cancer: Role of HPV 16 Variants |
| title_full_unstemmed | Metabolic Reprogramming in Cancer: Role of HPV 16 Variants |
| title_short | Metabolic Reprogramming in Cancer: Role of HPV 16 Variants |
| title_sort | metabolic reprogramming in cancer role of hpv 16 variants |
| topic | HPV 16 variants metabolic reprogramming cancer |
| url | https://www.mdpi.com/2076-0817/10/3/347 |
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