A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity
Curcumin is a polyphenol compound derived from the rhizomes of <i>Curcuma longa</i> that exhibits antioxidant, anti-inflammatory, anticancer, and antimicrobial properties. However, its low solubility in aqueous solutions, low absorption following oral administration, and rapid degradatio...
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MDPI AG
2019-07-01
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author | Myoung-Sook Shin Jun Sang Yu Jaemin Lee Young Seok Ji Hee Joung Joung Yu-Mee Han Hye Hyun Yoo Ki Sung Kang |
author_facet | Myoung-Sook Shin Jun Sang Yu Jaemin Lee Young Seok Ji Hee Joung Joung Yu-Mee Han Hye Hyun Yoo Ki Sung Kang |
author_sort | Myoung-Sook Shin |
collection | DOAJ |
description | Curcumin is a polyphenol compound derived from the rhizomes of <i>Curcuma longa</i> that exhibits antioxidant, anti-inflammatory, anticancer, and antimicrobial properties. However, its low solubility in aqueous solutions, low absorption following oral administration, and rapid degradation limit its use as a functional food material. In this study, a hydroxypropyl methylcellulose-based solid dispersion of curcumin (DW-CUR 20) was prepared and its bioavailability was evaluated. In addition, its therapeutic efficacy as a hepatoprotective agent was investigated using the model of tert-butyl hydroperoxide (t-BHP)-induced hepatocyte damage. The rat plasma pharmacokinetic study showed that the oral curcumin bioavailability of DW-CUR 20 significantly increased compared to that of non-formulated curcumin. DW-CUR 20 showed a concentration-dependent hepatocyte protective effect on t-BHP-induced HepG2 cells. DW-CUR 20 inhibited the release of lactate dehydrogenase and decreased apoptosis-related proteins such as Poly (ADP-ribose) polymerase, cleaved caspase-7 and cleaved caspase-8 on t-BHP-treated HepG2 cells. These findings suggest that DW-CUR 20 could be a promising formulation for enhancing the therapeutic efficiency of curcumin and for improving the safety. |
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issn | 2218-273X |
language | English |
last_indexed | 2024-12-11T01:21:32Z |
publishDate | 2019-07-01 |
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spelling | doaj.art-17bc4622c8c34c4ebdeb3ca3cd18061f2022-12-22T01:25:42ZengMDPI AGBiomolecules2218-273X2019-07-019728110.3390/biom9070281biom9070281A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective ActivityMyoung-Sook Shin0Jun Sang Yu1Jaemin Lee2Young Seok Ji3Hee Joung Joung4Yu-Mee Han5Hye Hyun Yoo6Ki Sung Kang7College of Korean Medicine, Gachon University, Seongnam 13120, KoreaInstitute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan 15588, KoreaCollege of Korean Medicine, Gachon University, Seongnam 13120, KoreaInstitute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan 15588, KoreaDongoh Life Science Co., Ltd., #301B Venture Center, Jeonju 55069, KoreaDongoh Life Science Co., Ltd., #301B Venture Center, Jeonju 55069, KoreaInstitute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan 15588, KoreaCollege of Korean Medicine, Gachon University, Seongnam 13120, KoreaCurcumin is a polyphenol compound derived from the rhizomes of <i>Curcuma longa</i> that exhibits antioxidant, anti-inflammatory, anticancer, and antimicrobial properties. However, its low solubility in aqueous solutions, low absorption following oral administration, and rapid degradation limit its use as a functional food material. In this study, a hydroxypropyl methylcellulose-based solid dispersion of curcumin (DW-CUR 20) was prepared and its bioavailability was evaluated. In addition, its therapeutic efficacy as a hepatoprotective agent was investigated using the model of tert-butyl hydroperoxide (t-BHP)-induced hepatocyte damage. The rat plasma pharmacokinetic study showed that the oral curcumin bioavailability of DW-CUR 20 significantly increased compared to that of non-formulated curcumin. DW-CUR 20 showed a concentration-dependent hepatocyte protective effect on t-BHP-induced HepG2 cells. DW-CUR 20 inhibited the release of lactate dehydrogenase and decreased apoptosis-related proteins such as Poly (ADP-ribose) polymerase, cleaved caspase-7 and cleaved caspase-8 on t-BHP-treated HepG2 cells. These findings suggest that DW-CUR 20 could be a promising formulation for enhancing the therapeutic efficiency of curcumin and for improving the safety.https://www.mdpi.com/2218-273X/9/7/281hydroxypropyl methylcellulosecurcuminbioavailabilityhepatoprotective |
spellingShingle | Myoung-Sook Shin Jun Sang Yu Jaemin Lee Young Seok Ji Hee Joung Joung Yu-Mee Han Hye Hyun Yoo Ki Sung Kang A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity Biomolecules hydroxypropyl methylcellulose curcumin bioavailability hepatoprotective |
title | A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity |
title_full | A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity |
title_fullStr | A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity |
title_full_unstemmed | A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity |
title_short | A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity |
title_sort | hydroxypropyl methylcellulose based solid dispersion of curcumin with enhanced bioavailability and its hepatoprotective activity |
topic | hydroxypropyl methylcellulose curcumin bioavailability hepatoprotective |
url | https://www.mdpi.com/2218-273X/9/7/281 |
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