A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity

Curcumin is a polyphenol compound derived from the rhizomes of <i>Curcuma longa</i> that exhibits antioxidant, anti-inflammatory, anticancer, and antimicrobial properties. However, its low solubility in aqueous solutions, low absorption following oral administration, and rapid degradatio...

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Main Authors: Myoung-Sook Shin, Jun Sang Yu, Jaemin Lee, Young Seok Ji, Hee Joung Joung, Yu-Mee Han, Hye Hyun Yoo, Ki Sung Kang
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Biomolecules
Subjects:
Online Access:https://www.mdpi.com/2218-273X/9/7/281
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author Myoung-Sook Shin
Jun Sang Yu
Jaemin Lee
Young Seok Ji
Hee Joung Joung
Yu-Mee Han
Hye Hyun Yoo
Ki Sung Kang
author_facet Myoung-Sook Shin
Jun Sang Yu
Jaemin Lee
Young Seok Ji
Hee Joung Joung
Yu-Mee Han
Hye Hyun Yoo
Ki Sung Kang
author_sort Myoung-Sook Shin
collection DOAJ
description Curcumin is a polyphenol compound derived from the rhizomes of <i>Curcuma longa</i> that exhibits antioxidant, anti-inflammatory, anticancer, and antimicrobial properties. However, its low solubility in aqueous solutions, low absorption following oral administration, and rapid degradation limit its use as a functional food material. In this study, a hydroxypropyl methylcellulose-based solid dispersion of curcumin (DW-CUR 20) was prepared and its bioavailability was evaluated. In addition, its therapeutic efficacy as a hepatoprotective agent was investigated using the model of tert-butyl hydroperoxide (t-BHP)-induced hepatocyte damage. The rat plasma pharmacokinetic study showed that the oral curcumin bioavailability of DW-CUR 20 significantly increased compared to that of non-formulated curcumin. DW-CUR 20 showed a concentration-dependent hepatocyte protective effect on t-BHP-induced HepG2 cells. DW-CUR 20 inhibited the release of lactate dehydrogenase and decreased apoptosis-related proteins such as Poly (ADP-ribose) polymerase, cleaved caspase-7 and cleaved caspase-8 on t-BHP-treated HepG2 cells. These findings suggest that DW-CUR 20 could be a promising formulation for enhancing the therapeutic efficiency of curcumin and for improving the safety.
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spelling doaj.art-17bc4622c8c34c4ebdeb3ca3cd18061f2022-12-22T01:25:42ZengMDPI AGBiomolecules2218-273X2019-07-019728110.3390/biom9070281biom9070281A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective ActivityMyoung-Sook Shin0Jun Sang Yu1Jaemin Lee2Young Seok Ji3Hee Joung Joung4Yu-Mee Han5Hye Hyun Yoo6Ki Sung Kang7College of Korean Medicine, Gachon University, Seongnam 13120, KoreaInstitute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan 15588, KoreaCollege of Korean Medicine, Gachon University, Seongnam 13120, KoreaInstitute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan 15588, KoreaDongoh Life Science Co., Ltd., #301B Venture Center, Jeonju 55069, KoreaDongoh Life Science Co., Ltd., #301B Venture Center, Jeonju 55069, KoreaInstitute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan 15588, KoreaCollege of Korean Medicine, Gachon University, Seongnam 13120, KoreaCurcumin is a polyphenol compound derived from the rhizomes of <i>Curcuma longa</i> that exhibits antioxidant, anti-inflammatory, anticancer, and antimicrobial properties. However, its low solubility in aqueous solutions, low absorption following oral administration, and rapid degradation limit its use as a functional food material. In this study, a hydroxypropyl methylcellulose-based solid dispersion of curcumin (DW-CUR 20) was prepared and its bioavailability was evaluated. In addition, its therapeutic efficacy as a hepatoprotective agent was investigated using the model of tert-butyl hydroperoxide (t-BHP)-induced hepatocyte damage. The rat plasma pharmacokinetic study showed that the oral curcumin bioavailability of DW-CUR 20 significantly increased compared to that of non-formulated curcumin. DW-CUR 20 showed a concentration-dependent hepatocyte protective effect on t-BHP-induced HepG2 cells. DW-CUR 20 inhibited the release of lactate dehydrogenase and decreased apoptosis-related proteins such as Poly (ADP-ribose) polymerase, cleaved caspase-7 and cleaved caspase-8 on t-BHP-treated HepG2 cells. These findings suggest that DW-CUR 20 could be a promising formulation for enhancing the therapeutic efficiency of curcumin and for improving the safety.https://www.mdpi.com/2218-273X/9/7/281hydroxypropyl methylcellulosecurcuminbioavailabilityhepatoprotective
spellingShingle Myoung-Sook Shin
Jun Sang Yu
Jaemin Lee
Young Seok Ji
Hee Joung Joung
Yu-Mee Han
Hye Hyun Yoo
Ki Sung Kang
A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity
Biomolecules
hydroxypropyl methylcellulose
curcumin
bioavailability
hepatoprotective
title A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity
title_full A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity
title_fullStr A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity
title_full_unstemmed A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity
title_short A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity
title_sort hydroxypropyl methylcellulose based solid dispersion of curcumin with enhanced bioavailability and its hepatoprotective activity
topic hydroxypropyl methylcellulose
curcumin
bioavailability
hepatoprotective
url https://www.mdpi.com/2218-273X/9/7/281
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